A5081164244- SARS-CoV-2 and COVID-19 Research
- Immunotherapy and Immune Responses
- Heparin-Induced Thrombocytopenia and Thrombosis
- Intramuscular injections and effects
- COVID-19 Clinical Research Studies
- Viral Infections and Immunology Research
- Animal Virus Infections Studies
- Peripheral Neuropathies and Disorders
- Tuberculosis Research and Epidemiology
- Thermal Regulation in Medicine
- Mosquito-borne diseases and control
- Infectious Diseases and Tuberculosis
- Receptor Mechanisms and Signaling
- Radiopharmaceutical Chemistry and Applications
- Bone health and treatments
- Vector-borne infectious diseases
- T-cell and B-cell Immunology
- Orthopedic Infections and Treatments
- Complement system in diseases
- Transplantation: Methods and Outcomes
- Prostate Cancer Treatment and Research
- Cardiac Structural Anomalies and Repair
- bioluminescence and chemiluminescence research
- Nicotinic Acetylcholine Receptors Study
- Inflammatory Bowel Disease
Johns Hopkins University
2018-2024
Johns Hopkins Medicine
2018-2024
University Hospital of Zurich
2011
PET reveals spatially heterogeneous rifampin brain penetration, which decreases rapidly with treatment during tuberculous meningitis.
The pathophysiology of post-treatment Lyme disease syndrome (PTLDS) may be linked to overactive immunity including aberrant activity the brain's resident immune cells, microglia. Here we used [11C]DPA-713 and positron emission tomography quantify 18 kDa translocator protein, a marker activated microglia or reactive astrocytes, in brains patients with symptoms any duration compared healthy controls. Genotyping for TSPO rs6971 polymorphism was completed, individuals rare, low affinity binding...
Bone metastases in prostate cancer (PCa) have important prognostic significance, and imaging modalities used for PCa staging should high sensitivity detecting such lesions. Prostate-specific membrane antigen (PSMA)–targeted PET radiotracers are promising new agents PCa. We undertook a head-to-head comparison of PSMA-targeted 2-(3-{1-carboxy-5-[(6-<sup>18</sup>F-fluoro-pyridine-3-carbonyl)-amino]-pentyl}-ureido)-pentanedioic acid (<sup>18</sup>F-DCFPyL) to Na<sup>18</sup>F determine which...
Emerging evidence supports a hypothesized role for the α7-nicotinic acetylcholine receptor (α7-nAChR) in pathophysiology of Alzheimer's disease. <sup>18</sup>F-ASEM (3-(1,4-diazabicyclo[3.2.2]nonan-4-yl)-6-<sup>18</sup>F-fluorodibenzo[b,d]thiophene 5,5-dioxide) is radioligand estimating availability α7-nAChR brain vivo with PET. <b>Methods:</b> In this cross-sectional study, 14 patients mild cognitive impairment (MCI), prodromal stage to dementia, and 17 cognitively intact, elderly controls...
Persistence of antibody response after two-dose SARS-CoV-2 mRNA vaccination has been shown for up to 6 months in immunocompetent populations.1Doria-Rose N Suthar MS Makowski M et al.Antibody persistence through the second dose mRNA-1273 vaccine COVID-19.N Engl J Med. 2021; 384: 2259-2261Crossref PubMed Scopus (481) Google Scholar We previously confirmed a robust most patients with rheumatic and musculoskeletal diseases; however, we found attenuated responses on lymphocyte depleting...
The response to SARS-CoV-2 vaccination of patients with inflammatory bowel disease (IBD) on immune-modifying therapies requires further investigation because previous studies indicate that immune therapy might have decreased antibody concentrations.We present the antireceptor binding domain over a period 3 months in 217 IBD who completed standard 2-dose mRNA vaccine series.Almost all (98.6%) recipients had positive at least after vaccination. Decreased titers were seen subset antitumor...
We and others have previously reported suboptimal antibody responses in lung transplant recipients (LTRs) after 2 doses of SARS-CoV-2 mRNA vaccine.1,2 Immunosuppressive regimens that include antimetabolite therapy (AMT, mycophenolate or azathioprine)3 higher AMT4 been associated with poorer responses. Safety efficacy holding AMT around a third dose vaccine (D3) is being studied randomized trial kidney liver (NCT05077254), but the effects LTRs are unknown. At our center, who were >1 y...
Aim: This study aimed to summarise our recent clinical experience with children and adolescents selected for heart transplantation a focus on morbidity mortality during the waiting time.Methods: was single centre, retrospective of all consecutive patients listed between 1994 2008 who were less than 20 years old.Clinical parameters, ECG, echocardiography catheter data as well duration complications mechanical circulatory support, reviewed from date listing or death.Results: The population...
Background: The emergence of new SARS-CoV-2 variants calls for more data on mRNA vaccine response. Aims: We aimed to assess the response a third dose against in inflammatory bowel disease (IBD) patients. Methods: This was single-center, observational prospective study IBD patients who received SARS-CoV-2. Antibody titers were taken post-third-dose at one and three months using Roche Elecsys anti-SARS-CoV-2-S enzyme immunoassay. Titers less than 0.8 units/mL considered negative according...