A5086637822- Inflammatory Bowel Disease
- Microscopic Colitis
- Pregnancy and Medication Impact
- Genetic factors in colorectal cancer
- Eosinophilic Esophagitis
- Colorectal Cancer Screening and Detection
- Diagnosis and treatment of tuberculosis
- Autoimmune and Inflammatory Disorders
- Colorectal Cancer Treatments and Studies
- Diverticular Disease and Complications
- Reproductive System and Pregnancy
- Gastrointestinal disorders and treatments
- Viral Infections and Outbreaks Research
- Systemic Sclerosis and Related Diseases
- Dermatological and COVID-19 studies
- Celiac Disease Research and Management
- Gastric Cancer Management and Outcomes
- Gastrointestinal Tumor Research and Treatment
- Telomeres, Telomerase, and Senescence
- Appendicitis Diagnosis and Management
- SARS-CoV-2 and COVID-19 Research
- Immunotherapy and Immune Responses
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- IL-33, ST2, and ILC Pathways
- Long-Term Effects of COVID-19
Kaiser Permanente South San Francisco Medical Center
2024
Johns Hopkins Medicine
2015-2023
Johns Hopkins University
2015-2023
Johns Hopkins Hospital
2017
University of North Carolina at Chapel Hill
2017
University of San Francisco
2013
University of California, San Francisco
2003-2011
Carl T. Hayden Veterans Affairs Medical Center
2008
San Francisco VA Medical Center
2003
Iuliu Hațieganu University of Medicine and Pharmacy
2000
Abstract Purpose: The BRAF gene encodes a serine/threonine kinase and plays an important role in the mitogen-activated protein signaling pathway. mutations sporadic colorectal cancer with microsatellite instability (MSI) are more frequently detected than those stable cancer. In this study, we sought to compare frequencies of MSI hereditary nonpolyposis (HNPCC). Experimental Design: We analyzed 26 cell lines, 80 cancers, 20 tumors from HNPCC patients by DNA sequencing sequence-specific PCR....
Increasing evidence supports immediate colectomy in acute fulminant ulcerative colitis comparison with ongoing medical management. Prior studies have been limited to inpatient-only administrative data sets or single-institution experiences.The purpose of this study was compare outcomes early versus delayed emergency patients admitted flares while controlling for known preoperative risks and acuity.This is a cohort undergoing emergent total abdominal colectomies compared by the timing...
Screening adenomas for microsatellite instability (MSI) in patients younger than 40 yr of age has been recommended by the Bethesda Guidelines as a means identifying at risk hereditary nonpolyposis colorectal cancer (HNPCC). We sought to determine rate MSI removed from individuals under over 5-yr period university general gastroenterology practice.We identified between 18 and 39 with endoscopically adenomatous polyps. Patients polyposis syndromes, inflammatory bowel disease, or carcinoma were...
Abstract Background People with autoimmune or inflammatory conditions taking immunomodulatory/suppressive medications may have higher risk of novel coronavirus disease 2019 (COVID-19). Chronic care has also changed for many patients, uncertain downstream consequences. Methods We included participants followed by specialists at Johns Hopkins. Participants completed periodic surveys querying comorbidities, disease-modifying medications, exposures, COVID-19 testing and outcomes, social...
Early discontinuation of infliximab (IFX) in pregnant women with inflammatory bowel disease (IBD) decreases the intrauterine fetal exposure to drug but may increase risk flaring leading poor pregnancy outcomes. In this study, we assessed impact early IFX on mother's activity and their at-risk babies.In a retrospective study Truven Health Analytics MarketScan database from 2011 2015, compared IBD patients who discontinued more than 90 days ("early IFX") those discontinue or less ("late IFX)...
Abstract Background Inflammatory bowel disease (IBD) is a global healthcare problem that affects around 3 million people in the United States. Although impact of gender-affirming hormone therapy (GAHT) on IBD severity has been studied cisgender patients, there currently no literature exogenous (HT) transgender and nonbinary (TGNB) individuals. Methods We conducted retrospective chart review TGNB adults diagnosed with treated HT for gender dysphoria at Johns Hopkins Hospital (2015-2022)....
The response to SARS-CoV-2 vaccination of patients with inflammatory bowel disease (IBD) on immune-modifying therapies requires further investigation because previous studies indicate that immune therapy might have decreased antibody concentrations.We present the antireceptor binding domain over a period 3 months in 217 IBD who completed standard 2-dose mRNA vaccine series.Almost all (98.6%) recipients had positive at least after vaccination. Decreased titers were seen subset antitumor...
In inflammatory bowel disease (IBD), many scenarios call for fecal diversion, leaving behind defunctionalized bowel. The theoretical risk of colorectal cancer (CRC) in this segment is frequently cited as a reason resection. To date, no studies have characterized the incidence neoplasia diverted segments IBD patients. A retrospective cohort analysis was conducted patients identified through tertiary care center pathology database. Patients that had undergone diversion and were ≥ 1 year...
The existence of genetic anticipation has been long disputed in inflammatory bowel disease (IBD) the absence explanatory mechanism.To determine whether it was predictive anticipation, we evaluated telomere length IBD. We hypothesized that multiplex IBD families exhibit a defect impacting maintenance mechanisms.We studied three with multiple affected members successive generations. determined (TL) lymphocytes and granulocytes from peripheral blood using flow cytometry fluorescence in-situ...
Creation of a J pouch is the gold standard surgical intervention in treatment chronic ulcerative colitis (UC). Pouchoscopy prior to ileostomy takedown commonly performed. We describe frequency, indication, and findings on pouchoscopy, determine if pouchoscopy affects rates complications after takedown.All UC or indeterminate inflammatory bowel disease patients with were retrospectively evaluated from January 1994 December 2014. Cases defined as having routine (asymptomatic) creation but...
Introduction: We aim to investigate the risk associated with use of steroids, thiopurines and antitumor necrosis factor (anti-TNFs) in pregnant woman without Inflammatory Bowel Disease (IBD). Methods: reviewed all deliveries included Truven Health Analytics MarketScan database from January 2010 December 2012. Patients were divided 4 groups according exposure during pregnancy: unexposed, group A (thiopurines); B (anti-TNFs: infliximab, adalimumab, certolizumab); AB (both anti-TNFs), C...
ABSTRACT Background People with autoimmune or inflammatory conditions who take immunomodulatory/suppressive medications may have a higher risk of novel coronavirus disease 2019 (COVID-19). Chronic care has also changed for many patients, uncertain downstream consequences. Objective Assess whether COVID-19 is among those on immunomodulating suppressive agents and characterize pandemic-associated changes to care. Design Longitudinal registry study Participants 4666 individuals followed by...
Therapeutic drug monitoring (TDM) was one of most sought-after objective tools to determine therapeutic efficiency different biologics and its role in the management patients with inflammatory bowel disease (IBD) regarded great anticipation. But implementation TDM clinical practice challenged by several factors including uncertainty optimal cut-off values, assay variable sensitivity detecting levels antibodies and, importantly, individual pharmacokinetics. While reactive embraced as a useful...