A5012844708- Organ Donation and Transplantation
- Renal Transplantation Outcomes and Treatments
- SARS-CoV-2 and COVID-19 Research
- Hepatitis C virus research
- Organ Transplantation Techniques and Outcomes
- Animal Virus Infections Studies
- COVID-19 Clinical Research Studies
- Transplantation: Methods and Outcomes
- Vaccine Coverage and Hesitancy
- Liver Disease and Transplantation
- COVID-19 Impact on Reproduction
- Pneumocystis jirovecii pneumonia detection and treatment
- Reproductive Health and Technologies
- Neurological Complications and Syndromes
- Geriatric Care and Nursing Homes
- Pregnancy and Medication Impact
- Microbial infections and disease research
- Pediatric Hepatobiliary Diseases and Treatments
- Organ and Tissue Transplantation Research
- Palliative Care and End-of-Life Issues
- Assisted Reproductive Technology and Twin Pregnancy
- Grief, Bereavement, and Mental Health
- Hepatitis B Virus Studies
- Dialysis and Renal Disease Management
- Ethics and Legal Issues in Pediatric Healthcare
New York University
2022-2024
Johns Hopkins Hospital
2024
NYU Langone Health
2024
University of Wisconsin–Madison
2022
Johns Hopkins University
2021-2022
Johns Hopkins Medicine
2021-2022
National Institute of Allergy and Infectious Diseases
2022
National Institute of Diabetes and Digestive and Kidney Diseases
2022
Howard University Hospital
2022
Walter Reed National Military Medical Center
2021
Background. Solid organ transplant recipients (SOTRs) are less likely to mount an antibody response SARS-CoV-2 mRNA vaccines. Understanding risk factors for impaired vaccine can guide strategies testing and additional dose recommendations. Methods. Using a nationwide observational cohort of 1031 SOTRs, we created machine learning model explore, identify, rank, quantify the association 19 clinical with responses 2 doses External validation was performed using 512 SOTRs at Houston Methodist...
Heart transplants (HTs) from hepatitis C virus (HCV)-viremic donors to HCV-seronegative recipients (HCV D+/R-) have good 6-month outcomes, but practice uptake and long-term outcomes overall among candidates on mechanical circulatory support (MCS) yet be established.Using the Scientific Registry of Transplant Recipients, we identified US adult HT (R-) 2015 2021. We classified as (D-) or HCV-viremic (D+). used multivariable regression compare post-HT extracorporeal membranous oxygenation,...
A widely accepted severe acute respiratory syndrome 2 (SARS-CoV-2) vaccine could protect vulnerable populations, but the willingness of solid organ transplant recipients (SOTRs) to accept a potential remains unknown.
Alexandra T. Strauss and Amy Chang contributed equally to this article. Funding informationThis research was made possible with the generous support of Ben‐Dov family Trokhan Patterson family. This work supported by grants T32DK007732 (Amy Chang), T32DK007713 (Jennifer L. Alejo), F32DK124941 (Brian J. Boyarsky), K01DK114388–03 (Macey Levan), K01DK101677 (Allan B. Massie), K23DK115908 (Jacqueline M. Garonzik‐Wang) from National Institute Diabetes Digestive Kidney Diseases; K23AI157893...
Background. Living donor liver transplants (LDLTs) including those from nondirected donors (NDDs) have increased during the past decade, and center-level variations in LDLTs not yet been described. We sought to quantify changes volume of NDD over time variation between transplant centers. further examined characteristics living identified factors potentially associated with receiving an transplant. Methods. Using Scientific Registry Transplant Recipients data March 01, 2002, December 31,...
Advancements in medical technology, healthcare delivery, and organ allocation resulted improved patient/graft survival for older (age ≥65) kidney transplant (KT) recipients. However, the recent trends these post-KT outcomes are uncertain light of mounting burden cardiovascular disease, changing policies, heterogeneity candidates' risk profile, coronavirus disease 2019 pandemic. Thus, we examined secular among younger KT recipients over last 3 decades.We identified 73 078 378 800 adult (aged...
Following the outbreak of coronavirus disease 2019 (COVID-19) in United States, number kidney waitlist additions and living-donor deceased-donor transplants (LDKT/DDKT) decreased substantially but began recovering within a few months. Since then, there have been several additional waves infection, most notably, Delta Omicron surges beginning August December 2021, respectively.
Background. ABO type B and O kidney transplant candidates have increased difficulty identifying a compatible donor for living transplantation (LDKT) are harder to match in paired donation registries. A2-incompatible (A2i) LDKT increases access these patients. To better inform selection, we evaluated the association between A2i patient graft survival. Methods. We used weighted Cox regression compare mortality, death-censored failure, all-cause loss versus ABO-compatible (ABOc) recipients....
Background: The emergence of new SARS-CoV-2 variants calls for more data on mRNA vaccine response. Aims: We aimed to assess the response a third dose against in inflammatory bowel disease (IBD) patients. Methods: This was single-center, observational prospective study IBD patients who received SARS-CoV-2. Antibody titers were taken post-third-dose at one and three months using Roche Elecsys anti-SARS-CoV-2-S enzyme immunoassay. Titers less than 0.8 units/mL considered negative according...
OBJECTIVES/GOALS: Disparities in pediatric kidney transplantation (KT) result reduced access and worse outcomes for minority children. We aimed to assess the impact of recent systemic changes on these disparities. METHODS/STUDY POPULATION: Retrospective cohort study patients utilizing data from United States Renal Data System (USRDS) Scientific Registry Transplant Recipients (SRTR). compared transplantation, time deceased donor transplant (DDKT), allograft failure (ACGF) using Cox...
Purpose: Liver transplant (LT) recipients have a decreased response to 2 doses of SARS-CoV-2 vaccine compared the general population, so we aimed understand third dose inform vaccination strategies. Methods: LT with 3 congruent mRNA vaccines and antibody levels pre- post-dose (D3) were included. Those who reported prior COVID-19 diagnosis or used belatacept excluded. The latest anti-spike level collected between second (D2) was at 1 month post-D3. Samples tested Roche Elecsys Anti-Sars-CoV-2...
Background: Following the outbreak of COVID-19 in United States, number kidney waitlist additions and living-donor deceased-donor transplants (LDKT/DDKT) decreased substantially but began recovering within a few months. Since then, there have been several additional waves infection, most notably, Delta current Omicron surge beginning August December 2021, respectively. By 1/12/2022, peaked at 802,699 confirmed new cases, compared to pre-Omicron peak 251,772 cases on 1/8/2021, demonstrating...
Introduction: Waitlist candidates who accept the offer of a sclerotic kidney are faced with increased risk delayed graft function and loss, but decline must wait for future that could involve additional risks or may never materialize. To investigate potential benefits accepting kidney, we compared patient mortality between recipients kidneys waitlist declined offers same kidneys. Methods: Using national registry data from United States (SRTR), identified all deceased donors at least 20%...
Background: ABO type B and O kidney transplant candidates often have increased difficulty identifying a compatible donor for living transplantation (LDKT) are harder to match in paired donation (KPD) registries. A2-incompatible (A2i) LDKT increases access these patients. Kidney across the A2 barrier (A2 -> O, B, A2B B) is believed be safer than that A1 (A1 A1B because kidneys express fewer A antigens on their renal endothelial surfaces. However, differential risk of A2i its relative benefit...
Purpose: Following a sudden and tragic loss, organ donor families’ members experience grief, may even develop prolonged grief disorder. All US procurement organizations (OPOs) provide family support aftercare services for families, but the breadth focus of vary across OPOs. We assessed scope gaps existing in its territories. Methods: Family service offerings were identified through each OPOs website (n =57), (Table 1). used qualitative content analysis to identify topics covered delivery...