A5101989302- Ultrasound and Hyperthermia Applications
- SARS-CoV-2 and COVID-19 Research
- Microbial Inactivation Methods
- Ultrasound and Cavitation Phenomena
- Animal Virus Infections Studies
- Renal Transplantation Outcomes and Treatments
- COVID-19 Clinical Research Studies
- Neuroscience of respiration and sleep
- Pancreatic function and diabetes
- Neonatal Respiratory Health Research
- Heparin-Induced Thrombocytopenia and Thrombosis
- Pancreatitis Pathology and Treatment
- Cancer Research and Treatments
- Glioma Diagnosis and Treatment
- Brain Metastases and Treatment
- 3D Printing in Biomedical Research
- Fungal Biology and Applications
- Cancer, Stress, Anesthesia, and Immune Response
- T-cell and B-cell Immunology
- Antimicrobial Resistance in Staphylococcus
- Healthcare Systems and Technology
- Antibiotic Use and Resistance
- Infective Endocarditis Diagnosis and Management
- Cancer Cells and Metastasis
- Polyomavirus and related diseases
Johns Hopkins University
2021-2025
East Carolina University
2025
University of Vermont
2022-2024
Johns Hopkins Medicine
2021-2023
University of Baltimore
2023
The University of Western Australia
2016-2022
Hong Kong Sanatorium and Hospital
2022
Wake Forest University
2019-2020
Yale University
1987-2014
Harvard University
1977
The hexapeptide SLIGRL-amide activates protease-activated receptor-2 (PAR-2) and mas-related G protein-coupled receptor C11 (MRGPRC11), both of which are known to be expressed on populations sensory nerves. has recently been reported inhibit influenza A (IAV) infection in mice independently PAR-2 activation, however the explicit roles MRGPRC11 nerves this process unknown. Thus, principal aim study was determine whether SLIGRL-amide-induced inhibition is mediated by and/or capsaicin-sensitive...
Organ Procurement and Transplantation Network (OPTN) policy requires 2 years of follow-up for living kidney donors (LKDs); however, many transplant hospitals struggle to meet this requirement. We developed tested a mobile health (mHealth) system LKD in pilot randomized-controlled trial (RCT). LKDs were randomly assigned either the intervention (mHealth + standard care) or control arm (standard care). assessed OPTN policy-defined completeness timeliness 6-month, 1-year, 2-year follow-ups....
Neutralizing antibody responses are attenuated in many solid organ transplant recipients (SOTRs) despite SARS-CoV-2 vaccination. Pre-exposure prophylaxis (PrEP) with the monoclonal combination Tixagevimab and Cilgavimab (T+C) might augment immunoprotection, yet activity against Omicron sublineages vaccinated SOTRs is unknown. Vaccinated who received 300+300mg T+C (either single dose or two 150+150mg doses) within a prospective observational cohort submitted pre- post-injection samples...
Background. The SARS-CoV-2 Omicron BA.5 subvariant escapes vaccination-induced neutralizing antibodies because of mutations in the spike (S) protein. Solid organ transplant recipients (SOTRs) develop high COVID-19 morbidity and poor variant recognition after vaccination. T cell responses may provide a second line defense. Therefore, understanding which vaccine regimens induce robust, conserved is critical.
Background. Solid organ transplant recipients (SOTRs) are less likely to mount an antibody response SARS-CoV-2 mRNA vaccines. Understanding risk factors for impaired vaccine can guide strategies testing and additional dose recommendations. Methods. Using a nationwide observational cohort of 1031 SOTRs, we created machine learning model explore, identify, rank, quantify the association 19 clinical with responses 2 doses External validation was performed using 512 SOTRs at Houston Methodist...
Patients with brain metastases (BMETS) need information about the prognosis and potential value of treatment options to make informed therapeutic decisions, but tools predict survival in contemporary practice are scarce. We propose an Updated Recursive Partitioning Analysis (U-RPA) instrument benefit from brain-directed (BDT) patients. This was a retrospective analysis patients BMETS treated between 2017 2019. With as primary endpoint, we calculated U-RPA generated estimates using...
Two general kinds of exocytotic secretion proteins are known: that which is stimulated by secretagogues; and constitutive exocytosis, unable to be stimulated. The exocrine pancreas has often been cited as a model system for the first kind secretion. However, release digestive enzymes from 1-day prenatal rats cannot therefore, its constitutive. To gain insight into intracellular pathways mediate in fetal gland, we examined kinetics newly synthesized proteins. We find steady state releases...
Alexandra T. Strauss and Amy Chang contributed equally to this article. Funding informationThis research was made possible with the generous support of Ben‐Dov family Trokhan Patterson family. This work supported by grants T32DK007732 (Amy Chang), T32DK007713 (Jennifer L. Alejo), F32DK124941 (Brian J. Boyarsky), K01DK114388–03 (Macey Levan), K01DK101677 (Allan B. Massie), K23DK115908 (Jacqueline M. Garonzik‐Wang) from National Institute Diabetes Digestive Kidney Diseases; K23AI157893...
To implicate the Ca2+-calmodulin-dependent protein kinase (CDPK) in secretory response of pancreatic acinar cells to postnatal neurohumoral stimulation, we examined enzymatic activity during development. CDPK was investigated by measuring phosphorylation endogenous proteins and an exogenous substrate, synapsin I. Ca2+-calmodulin (CaM)-stimulated as well I progressively increased supernatants from rats increasing age. When compared with embryonic pancreas (1 day before birth),...
<title>Abstract</title> Background There is an increase of patients with infective endocarditis who undergo patient-directed discharge prior to completion the recommended duration parenteral antibiotics. Outcomes do or not have been clearly elucidated. Methods A retrospective cohort study was done on all adult admitted at a single center between 2010–2020 did discharge. The authors compared baseline characteristics as well 30-day, 90-day, 1-year, and 2-year outcomes. Results total 389 were...
Fetal airway smooth muscle (ASM) exhibits phasic contractile behavior, which transitions to a more sustained “tonic” contraction after birth. The timing and underlying mechanisms of ASM transition from tonic phenotype are yet be established. We characterized in preterm (128 day gestation), term (∼150 1–4 month, 1 yr, adult sheep (5yr). Spontaneous activity was measured bronchial segments as amplitude, frequency, intensity. mechanism investigated further with computational model force...
AbstractEpithelial cells are bound by a plasma membrane that is divided into apical and basolateral domains. In turn, the species of proteins within these polarized plasmalemmal domains define structural functional specializations epithelium. Currently, research mechanisms whereby epithelial cell polarity generated major thrust in biology. The topic discussed here will focus on recent studies carried out us genesis regulated secretion developing pancreatic acinar cell—that is, secretory...
Abnormalities of the airway smooth muscle (ASM) layer in asthma may develop before birth. We hypothesize that antenatal inflammation causes physiological abnormalities ASM predisposes asthma. This study determined short-term effects on developing ASM. Fourteen pregnant ewes were randomly assigned to one three groups. Fetal lambs exposed intra-amniotic injections lipopolysaccharide (LPS, n = 4) or saline (controls; 5) at 127 days' gestational age (GA). Preterm surgically delivered 129 GA and...