A5003102672- Gastric Cancer Management and Outcomes
- Liver Disease and Transplantation
- Radiomics and Machine Learning in Medical Imaging
- Pancreatic and Hepatic Oncology Research
- Organ Transplantation Techniques and Outcomes
- Liver Disease Diagnosis and Treatment
- Colorectal Cancer Screening and Detection
- SARS-CoV-2 and COVID-19 Research
- COVID-19 Clinical Research Studies
- Renal Transplantation Outcomes and Treatments
- Hepatitis C virus research
- Hepatocellular Carcinoma Treatment and Prognosis
- Machine Learning in Healthcare
- Neuroinflammation and Neurodegeneration Mechanisms
- Alzheimer's disease research and treatments
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Pancreatitis Pathology and Treatment
- Renal cell carcinoma treatment
- Emergency and Acute Care Studies
- Hepatitis B Virus Studies
- Inflammatory Bowel Disease
- Electronic Health Records Systems
- Animal Virus Infections Studies
- Bladder and Urothelial Cancer Treatments
- Geriatric Care and Nursing Homes
Johns Hopkins University
2018-2025
Johns Hopkins Medicine
2018-2025
University of Cambridge
2024
Cambridge University Hospitals NHS Foundation Trust
2024
Johns Hopkins Hospital
2019-2024
University of Pennsylvania
2020
University of South Florida
2015-2018
James A. Haley Veterans' Hospital
2018
Thomas Jefferson University
2017
Levi Strauss (United States)
2016
Traditionally, liver transplant (LT) for alcohol-associated disease (ALD) requires 6 months of abstinence. Although early LT before abstinence has been associated with decreased mortality decompensated ALD, this practice remains controversial and concentrated at a few centers.To define patient, allograft, relapse-free survival in to investigate the association between these outcomes vs standard LT.This cohort study analyzed all patients ALD who underwent their first single academic referral...
Strauss, Alexandra T. M.D., M.I.E.; Hallett, Andrew M. M.D.; Boyarsky, Brian J. Ou, Michael B.S.; Werbel, William A. Avery, Robin K. Tobian, Aaron R. Ph.D.; Massie, Allan B. Hamilton, James P. Garonzik‐Wang, Jacqueline Segev, Dorry L. Ph.D. Author Information
Abnormal liver chemistries are common findings in patients with Coronavirus Disease 2019 (COVID-19). However, the association of these abnormalities severity COVID-19 and clinical outcomes is poorly understood.We aimed to assess prevalence elevated hospitalized compare serum predict in-hospital mortality.This retrospective, observational study included 3380 who were Johns Hopkins Health System (Baltimore, MD, United States). Demographic data, characteristics, laboratory findings, treatment...
Abstract Racial and ethnic disparities persist in access to the liver transplantation (LT) waiting list; however, there is limited knowledge about underlying system‐level factors that may be responsible for these disparities. Given complex nature of LT candidate evaluation, a human systems engineering approach provide insights. We recruited participants from teams (coordinators, advanced practice providers, physicians, social workers, dieticians, pharmacists, leadership) at two major...
COVID-19 has profoundly affected the American health care system; its effect on liver transplant (LT) waitlist based incidence not been characterized. Using SRTR data, we compared observed LT registrations, mortality, deceased donor LTs (DDLT), and living (LDLT) 3/15/2020-8/31/2020 to expected values historical trends 1/2016-1/2020, stratified by statewide incidence. Overall, from 3/15 4/30, new listings were 11% fewer than (IRR =
Neuroinflammation is an important pathogenic mechanism in many neurodegenerative diseases, including those caused by frontotemporal lobar degeneration. Post-mortem and vivo imaging studies have shown brain inflammation early these conditions, proportional to symptom severity rate of progression. However, evidence for corresponding blood markers their relationships central clinical outcome are limited. There a pressing need such scalable, accessible mechanistically relevant because will...
Background: Patients with HCC face numerous barriers to curative therapies, particularly Black patients and those impacted by adverse social determinants of health (SDOH). This study aimed identify patient-reported facilitators inform interventions that improve equitable access care. Methods: We conducted 2 qualitative sessions participants experiencing SDOH referred for liver transplant (LT) or resection. also one-on-one interviews from underwent LT (n=2). Human-centered design methods,...
In our first survey of transplant centers in March 2020, >75% kidney and liver programs were either suspended or operating under restrictions. To safely resume transplantation, we must understand the evolving impact COVID-19 on recipients center-level practices. We therefore conducted a six-week follow-up May 7-15, linked responses to incidence map, with response rate 84%. Suspension live donor transplantation decreased from 72% 30% for kidneys 68% 52% livers. Restrictions/suspension...
Neighborhood socioeconomic deprivation may have important implications on disparities in liver transplant (LT) evaluation. In this retrospective cohort study, we constructed a novel dataset by linking individual patient-level data with the highly granular Area Deprivation Index (ADI), which is advantageous over other neighborhood measures due to: specificity of Census Block-Group (versus Tract, Zip code), scoring, and robust variables. Our included 1377 adults referred to our center for LT...
Hepatic steatosis is a precursor to more severe liver disease, increasing morbidity and mortality risks. In the Emergency Department, routine abdominal imaging often reveals incidental hepatic that goes undiagnosed due acute nature of encounters. Imaging reports in electronic health record contain valuable information not easily accessible as discrete data elements. We hypothesized large language models could reliably detect from without extensive natural processing training. identified 200...
Many deceased-donor and living-donor kidney transplants (KTs) rely on commercial airlines for transport. However, the coronavirus-19 pandemic has drastically impacted airline industry. To understand potential pandemic-related disruptions in transportation network of kidneys across United States, we used national flight data to compare scheduled flights during vs 1-year earlier, focusing Organ Procurement Organization (OPO) pairs between which historically most likely traveled by direct (High...
Delays in treatment for breast cancer can lead to poorer patient outcome. We analyzed time among female patients receiving breast-conserving surgery two different hospital settings, public versus private. Retrospective chart review revealed 270 diagnosed during 2004-2008. Three consecutive intervals were defined (Initial abnormal imaging [I] core biopsy [II] /pathology staging [III] oncology evaluation adjuvant treatment). Multivariate analyses investigated type and demographic factors....
Abstract Surgical resection for localized hepatocellular carcinoma (HCC) is typically reserved a minority of patients with favorable tumor features and anatomy. Neoadjuvant immunotherapy can expand the number who are candidates surgical potentially reduce chance recurrence, but its role in HCC not defined. We retrospectively examined outcomes underwent at Johns Hopkins Hospital compared clinical received neoadjuvant those upfront resection. The cohort included total 92 patients, 36 whom...
Important barriers for widespread use of health information exchange (HIE) are usability and interface issues. However, most HIEs implemented without performing a needs assessment with the end users, healthcare providers. We performed user process obtaining clinical from other care organizations about hospitalized patient identified types valued medical decision-making.Quantitative qualitative analysis were used to evaluate obtain outside (OI) using semi-structured interviews (16...
Demand has outstripped healthcare supply during the coronavirus disease 2019 (COVID-19) pandemic. Emergency departments (EDs) are tasked with distinguishing patients who require hospital resources from those may be safely discharged to community. The novelty and high variability of COVID-19 have made these determinations challenging. In this study, we developed, implemented evaluated an electronic health record (EHR) embedded clinical decision support (CDS) system that leverages machine...
Background: The use of large-scale data and artificial intelligence (AI) to support complex transplantation decisions is in its infancy. Transplant candidate decision-making, which relies heavily on subjective assessment (ie, high variability), provides a ripe opportunity for AI-based clinical decision (CDS). However, AI-CDS transplant applications must consider important concerns regarding fairness health equity). objective this study was human-centered design methods elicit providers’...
Abstract Using a Bayesian approach to epidemiological compartmental modeling, we demonstrate the “bomb-like” behavior of exponential growth in COVID-19 cases can be explained by transmission asymptomatic and mild that are typically unreported at beginning pandemic events due lower prevalence testing. We studied phase Italy, Spain, South Korea, found R 0 2.56 (95% CrI, 2.41-2.71), 3.23 3.06-3.4), 2.36 2.22-2.5) if use priors assume large portion not detected. Weaker regarding detection rate...
Metastasis of colon adenocarcinoma is commonly found in the lung, liver, or peritoneum. Common bile duct (CBD) tumors related to adenomas from familial adenomatous polyposis metastasizing outside gastrointestinal tract have been reported. We report a case biliary colic due metastatic CBD. Obstructive jaundice with signs acalculous cholecystitis on imaging patient history cancer should raise suspicion for metastasis
Alexandra T. Strauss and Amy Chang contributed equally to this article. Funding informationThis research was made possible with the generous support of Ben‐Dov family Trokhan Patterson family. This work supported by grants T32DK007732 (Amy Chang), T32DK007713 (Jennifer L. Alejo), F32DK124941 (Brian J. Boyarsky), K01DK114388–03 (Macey Levan), K01DK101677 (Allan B. Massie), K23DK115908 (Jacqueline M. Garonzik‐Wang) from National Institute Diabetes Digestive Kidney Diseases; K23AI157893...