A5102838901- Neuroscience and Neuropharmacology Research
- Parkinson's Disease Mechanisms and Treatments
- Amyotrophic Lateral Sclerosis Research
- Neurotransmitter Receptor Influence on Behavior
- Genetic Neurodegenerative Diseases
- Botulinum Toxin and Related Neurological Disorders
- Neurological disorders and treatments
- Memory and Neural Mechanisms
- Alzheimer's disease research and treatments
- Neurogenetic and Muscular Disorders Research
- Functional Brain Connectivity Studies
- Dermatological and COVID-19 studies
- Pain Management and Treatment
- Gastrointestinal motility and disorders
- Autoimmune and Inflammatory Disorders
- Neuroscience and Neural Engineering
- Hydrogen's biological and therapeutic effects
- Peripheral Neuropathies and Disorders
- Neurological and metabolic disorders
- Long-Term Effects of COVID-19
- Phonocardiography and Auscultation Techniques
- Dementia and Cognitive Impairment Research
- Autism Spectrum Disorder Research
- Parathyroid Disorders and Treatments
- Autoimmune Bullous Skin Diseases
Chiba University
2016-2024
National Hospital Organization
2018-2022
Chiba Rosai Hospital
2019
Chiba East Hospital
2017
Fuji Xerox (Japan)
1998-2000
<h3>Importance</h3> The effectiveness of currently approved drugs for amyotrophic lateral sclerosis (ALS) is restricted; there a need to develop further treatments. Initial studies have shown ultrahigh-dose methylcobalamin be promising agent. <h3>Objective</h3> To validate the efficacy and safety patients with ALS enrolled within 1 year onset. <h3>Design, Setting, Participants</h3> This was multicenter, placebo-controlled, double-blind, randomized phase 3 clinical trial 12-week observation...
Single unit recording in rat nucleus accumbens (NAcc) was used to ascertain NAcc neuronal activity mediating of reward including its anticipation. Of the 103 neurons investigated, 63% showed some response connection with task activity. these, 20 units responded during delivery primary (food and/or water) and five time period preceding if delayed (four food, one water). These result suggest that not only inducing anticipation reward, but also represent difference quality between food water...
SUMMRAY A panel of radiochemicals has enabled in-vivo positron emission tomography (PET) tau pathologies in Alzheimer’s disease (AD), while sensitive detection frontotemporal lobar degeneration (FTLD) inclusions been unsuccessful. Here, we generated an imaging probe, PM-PBB3, for capturing diverse deposits. In-vitro assays demonstrated the reactivity this compound with AD and FTLD. We could also utilize PM-PBB3 optical/PET a living murine tauopathy model. subsequent clinical PET study...
Neuronal intranuclear inclusion disease (NIID) is a rare neurodegenerative disease. Pathologically, it characterized by eosinophilic hyaline inclusions in the cells of visceral organs as well central, peripheral, and autonomic nervous system cells. Recently, GGC repeat expansion NOTCH2NLC gene has been identified etiopathological agent NIID. Interestingly, this was also reported some patients with clinical diagnosis amyotrophic lateral sclerosis (ALS). However, there are no autopsy-confirmed...
Myoclonus and ataxia, with or without opsoclonus, have recently been recognized as a central nervous system syndrome associated coronavirus disease-2019 (COVID-19). A 52-year-old Japanese man developed myoclonus ataxia 16 days after the onset of COVID-19. Brain single-photon emission computed tomography (SPECT) revealed hyperperfusion in cerebellum hypoperfusion cerebral cortices frontal predominance during acute stage, which improved over two months. This study indicates that brain...
Hypercoagulability associated with malignant tumors causes thrombosis, termed Trousseau's syndrome, but is rarely benign gynecological tumors, such as myoma and adenomyosis. We herein report a 47-year-old Japanese woman uterine adenomyosis who developed multiple cerebral infarcts during menstruation. Edoxaban was initially used for prevention failed to prevent recurrence of thrombosis. However, hysterectomy bilateral salpingo-oophorectomy resulted in the successful infarct five years without...
Brain information processing is supported by the dual architecture of cortical and limbic systems for knowledge-based emotional information, respectively. We hypothesize this brain contributes to learning control. In order examine role emotion in forming memory that is, automatic algorithm acquisition, solidification retrieval, single unit recording was executed nucleus accumbens rat. The rat trained a circular open field develop its ability food water reward. After reward acquisition task...
Pareidolia is a visual illusion of meaningful objects that arise from ambiguous forms embedded in scenes. Previous studies showed pareidolias are frequently observed patients with Parkinson’s disease (PD) as well dementia Lewy bodies. However, whether useful for differentiating PD other neurodegenerative parkinsonism disorders including multiple system atrophy (MSA) unclear. The noise pareidolia test (NPT) was performed 40 and 48 MSA, respectively. A receiver operating characteristic (ROC)...
Background. Electrogastrography and electroenterography are noninvasive methods for measuring gastric intestinal electrical activities, respectively. Few studies have measured in healthy humans; however, no electrogastrography simultaneously. This study was performed to provide basic data comparison with future patients. Methods. Simultaneous preprandial postprandial measurements of were taken 30 min each 50 volunteers. Power spectrum analysis calculate dominant frequency, power, power...
Abstract Background Multiple system atrophy (MSA) is a progressive, incurable, life-threatening neurodegenerative disease uniquely characterized by the risk of sudden death, which makes diagnosis delivery challenging for neurologists. Empirical studies on breaking MSA are scarce, with no guidelines currently established. This study aimed to investigate neurologists’ current practices and experiences in delivering MSA. Methods We conducted multicenter online survey employed mixed-methods...
Intravascular lymphoma (IVL) is a rare disease form of malignant lymphoma, and it characterised by the selective growth cells within lumina vessels. Identification this at an early stage difficult because non-specific clinical symptoms neuroradiological findings. Most reported IVL cases are diagnosed post-mortem following autopsy. We report case patient who presented with status epilepticus (SE) as initial manifestation IVL. Despite administration anti-convulsant agents general care...
An absence of skin lesions at the neurological onset may obscure diagnosis neuro-Sweet disease (NSD). We herein report a 32-year-old man with NSD in whom symptoms preceded development by 10 years. The patient exhibited four distinct episodes: meningoencephalitis, scattered brain lesions, ocular flutter, and isolated seizures. Acute relapses responded to corticosteroid therapy, was successfully maintained on dapsone combination therapy. should be considered differential patients recurrent...
It is reported that correlation of inputs in a time domain plays an important role plasticity synaptic transmission. Here, we studied how correlated external stimulation modified responses the cortical networks. Rat neocortical neurons were cultured on electrode-array substrates and activity evoked by electrical from single site was compared between before after double stimulation. Double applied either simultaneously or with difference 500 ms. Either increase decrease observed seven cases...
Abstract Pure autonomic failure (PAF) and multiple system atrophy (MSA) are representative neurodegerative diseases present with a severe dysfunction in the urinary, cardiovascular, pupillary systems, as well gastrointestinal tract skin/sweat glands. Clinically PAF is characterized by chronic progressive pure occasionally associated parkinsonism or cognitive (Lewy body disease), whereas MSA cerebellar manifestation and/or parkinsonism. Pathology of both α‐synuclein deposition, but major...