A5028818051- Dementia and Cognitive Impairment Research
- Alzheimer's disease research and treatments
- Medical Imaging Techniques and Applications
- Diabetes and associated disorders
- Diabetes Management and Research
- Mental Health Research Topics
- Machine Learning in Healthcare
- Neural and Behavioral Psychology Studies
- Neurobiology of Language and Bilingualism
- Schizophrenia research and treatment
- Aging and Gerontology Research
- Stroke Rehabilitation and Recovery
- Decision-Making and Behavioral Economics
- Functional Brain Connectivity Studies
- Geriatric Care and Nursing Homes
- Treatment of Major Depression
- Psychology of Moral and Emotional Judgment
- Memory and Neural Mechanisms
- Emotion and Mood Recognition
- Advanced Neuroimaging Techniques and Applications
- Cell Adhesion Molecules Research
- Topic Modeling
- Health disparities and outcomes
- Digital Mental Health Interventions
- Autoimmune Bullous Skin Diseases
Keio University
2017-2025
Benesse Holdings (Japan)
2022
Keio University Hospital
2019-2020
Kyoto Prefectural University of Medicine
2020
Saitama Medical University
2019
National Institutes for Quantum Science and Technology
2010-2014
Imaging Center
2013
Centre for Nursing Innovation
2010
Tokyo Dental College Ichikawa General Hospital
2008
Osaka University
2008
<h3>Objective</h3> Neuropsychiatric symptoms affect many patients with Alzheimer9s disease (AD). (<sup>11</sup>C)Pittsburgh Compound-B (PIB) positron emission tomography (PET) has enabled the in vivo visualisation of brain amyloid-β (Aβ) deposition. This study exploratively investigated correlation between Aβ deposition measured by (<sup>11</sup>C)PIB PET and neuropsychiatric AD. <h3>Methods</h3> Participants were 28 (15 women, 13 men) PIB-positive Clinical assessments included Mini-Mental...
Artificial intelligence (AI) can provide many benefits in healthcare, including rapid and effective treatment options. However, previous research on human–computer interactions has demonstrated that people are reluctant to accept AI. This study compared individuals' trust AI with their doctors regarding medical explored whether an system understands suggests desired treatments. We conducted online experiment (N = 415) adopting a scenario method. The participants were asked imagine receiving...
Misestimating risk could lead to disadvantaged choices such as initiation of drug use (or gambling) and transition regular gambling). Although the normative theory in decision-making under risks assumes that people typically take probability-weighted expectation over possible utilities, experimental studies among suggest outcome probabilities are transformed nonlinearly into subjective decision weights by a nonlinear weighting function overweights low underweights high probabilities. Recent...
Background: In an aging society, neuropsychological testing using video teleconferencing (VTC) is increasingly important. Despite the potential benefit of a VTC-administered Montreal Cognitive Assessment Tool (MoCA) to detect cognitive decline, only limited number studies have investigated this tool's reliability. Therefore, we aimed evaluate reliability MoCA compared with face-to-face (FTF)-administered among elderly Japanese participants. Moreover, examined participants' satisfaction MoCA....
Clinical features of cognitive performance in extreme old age differ from those pathological decline Alzheimer's disease (AD). We compared traits between 638 centenarians aged 100-115 years and 208 221 patients with AD independent facilities. The presence the apolipoprotein E (APOE) ε4 allele did not affect Mini-Mental State Examination (MMSE) scores centenarians. Centenarians retained ability to follow three consecutive commands, associated their educational background activities daily...
How does one deal with unfair behaviors? This subject has long been investigated by various disciplines including philosophy, psychology, economics, and biology. However, our reactions to unfairness differ from individual another. Experimental economics studies using the ultimatum game (UG), in which players must decide whether accept or reject fair offers, have also shown that there are substantial differences reaction unfairness. little is known about psychological as well neurobiological...
The majority of individuals evaluate themselves as superior to average. This is a cognitive bias known the “superiority illusion.” illusion helps us have hope for future and deep-rooted in process human evolution. In this study, we examined default states neural molecular systems that generate illusion, using resting-state functional MRI PET. Resting-state connectivity between frontal cortex striatum regulated by inhibitory dopaminergic neurotransmission determines individual levels...
Abstract In recent years, studies on the use of natural language processing (NLP) approaches to identify dementia have been reported. Most these used picture description tasks or other similar encourage spontaneous speech, but free conversation without requiring a task might be easier perform in clinical setting. Moreover, is unlikely induce learning effect. Therefore, purpose this study was develop machine model discriminate subjects with and by extracting features from unstructured data...
Introduction Studies have demonstrated the high agreement of several remote neuropsychological tests using video teleconferencing (VTC) with face-to-face (FTF) tests. However, reliability remotely administered Alzheimer’s Disease Assessment Scale cognitive subscale (ADAS-cog), one most commonly used to detect decline, has not been substantially elucidated, particularly in Japanese populations. Therefore, this study aimed evaluate ADAS-cog compared FTF-administered among elderly participants....
Research on elderly financial exploitation has mostly focused abuse that occurs in families and other types of trusted relationships. As such, little is known about frauds scams perpetrated by strangers. Financial fraud scam prevention activities for older adults must be promoted, which the correlation between psychological, social, cognitive characteristics their vulnerability needs to determined. The present study aimed determine whether decline a risk factor adults. Thus, we created scale...
A 64-yr-old man with benign monoclonal gammopathy developed recurrent episodes of severe hypoglycemia but lacked evidence insulinoma or exogenous insulin administration. The patient's plasma was found to contain anti-insulin antibodies and large amounts extractable (1110 μU/ml), which identified as human by high-performance liquid chromatography (HPLC). consisted solely IgG A-light chains. Scatchard analysis these revealed an almost straightline relationship, markedly low affinity high...
To investigate the influence of replacing sedentary time with physical activity on cognitive function using an isotemporal substitution model in a population community-dwelling oldest old.This cross-sectional study included residents Arakawa ward, Tokyo, who were part prospective cohort from 85+ study. We measured 136 participants triaxial actigraph. Cognitive was Addenbrooke's Examination-III and divided into "cognitive decline group" (Addenbrooke's ≤88) maintain ≥89). Physical three...
In a 56-year-old woman with granulomas of gold thioglucose in her hips, who developed insulin autoimmune syndrome, the relationships among frequency or severity hypoglycemic attacks, serum (IRI) concentration, and characteristics antibodies were investigated during clinical course steroid treatment two resection operations for gold-thioglucose granulomas. When hypoglycemia was severe, total IRI level elevated, Scatchard analysis showed that high-affinity (k1), low-capacity (b1) population...
Characteristic neuropathologic changes in Alzheimer disease (AD) are amyloid-β deposits and neurofibrillary tangles. Recently, a new radioligand for amyloid senile plaques, <sup>11</sup>C-labeled 5-(6-{[tert-butyl(dimethyl)silyl]oxy}-1,3-benzothiazol-2-yl)pyridin-2-amine (<sup>11</sup>C-AZD2184), was developed, it reported to show rapid brain uptake followed by washout. In this study, <sup>11</sup>C-AZD2184 binding control subjects AD patients examined more detail compartment model analysis...
Depressive and neurocognitive disorders are debilitating conditions that account for the leading causes of years lived with disability worldwide. However, there no biomarkers objective or easy-to-obtain in daily clinical practice, which leads to difficulties assessing treatment response developing new drugs. New technology allows quantification features clinicians perceive as reflective disorder severity, such facial expressions, phonic/speech information, body motion, activity, sleep. Major...
Purpose: Current healthcare systems are not suitable for serving future societies in which the oldest old commonplace. The objective of this study was to understand what care most about their daily lives.Methods: Semi-structured in-depth interviews and thematic analysis were used. Face-to-face conducted 17 elderly residents (≥ 95 years) Arakawa-ku, Tokyo, Japan from July November 2017.Results: Three themes emerged interview responses: “unshakable beliefs social ties,” “natural acceptance,”...
We propose a non-invasive and cost-effective method to automatically detect dementia by utilizing solely speech audio data. extract paralinguistic features for short segment use Gated Convolutional Neural Networks (GCNN) classify it into or healthy. evaluate our on the Pitt Corpus own dataset, PROMPT Database. Our yields accuracy of 73.1% using an average 114 seconds In Database, 74.7% 4 data improves 80.8% when we all patient's Furthermore, three-class classification problem in which...
Some patients with the insulin autoimmune syndrome have circulating that is heterogenous. We used reverse phase high performance liquid chromatographic analysis to identify forms of plasma in this and compared results those insulin-treated diabetes hyperinsulinism. Under acidic conditions, free dissociated from antibodies eluted Bio-Gel P-30 columns as a single peak. When such fractions were applied chromatography, major peak emerged same retention time standard human all six syndrome. In...