A5057463057- Dementia and Cognitive Impairment Research
- Functional Brain Connectivity Studies
- Alzheimer's disease research and treatments
- Neurobiology of Language and Bilingualism
- EEG and Brain-Computer Interfaces
- Advanced Neuroimaging Techniques and Applications
- Stroke Rehabilitation and Recovery
- Neural dynamics and brain function
- Memory and Neural Mechanisms
- Epilepsy research and treatment
- Face Recognition and Perception
- Advanced MRI Techniques and Applications
- Cholinesterase and Neurodegenerative Diseases
- Neurological Disease Mechanisms and Treatments
- Sleep and Wakefulness Research
- Action Observation and Synchronization
- Intensive Care Unit Cognitive Disorders
- Vestibular and auditory disorders
- Health, Environment, Cognitive Aging
- Obstructive Sleep Apnea Research
- Neurological Disorders and Treatments
- Cerebrovascular and Carotid Artery Diseases
- Transcranial Magnetic Stimulation Studies
- Long-Term Effects of COVID-19
- Sleep and related disorders
Università Cattolica del Sacro Cuore
2016-2025
Agostino Gemelli University Polyclinic
2015-2025
Istituti di Ricovero e Cura a Carattere Scientifico
2002-2025
Steelcase (United States)
2024
University of Duisburg-Essen
2020
Fondazione Santa Lucia
1997-2020
Google (United States)
2019
Catholic University of America
2000-2018
University of the Sacred Heart
1995-2018
University of The Sacred Heart
2018
This study aimed at investigating the clinical usefulness of Mental Deterioration Battery (MDB) in neuropsychological diagnosis and characterization dementia syndrome. In this paper, we report: (a) normative data for various test scores derived from analysis performance 340 normal subjects living urban areas; (b) an evaluation reliability single tests battery as a whole differentiating patients affected by cognitive deterioration 130 rural areas 134 probable Alzheimer’s dementia; (c) cluster...
In March 2020, the World Health Organization declared a global pandemic due to novel coronavirus SARS-CoV-2 and several governments planned national quarantine in order control virus spread. Acute psychological effects of frail elderly subjects with special needs, such as patients dementia, have been poorly investigated. The aim this study was assess modifications neuropsychiatric symptoms during dementia their caregivers.This is sub-study multicenter nation-wide survey. A structured...
Previous studies showed that quarantine for pandemic diseases is associated with several psychological and medical effects. The consequences of COVID-19 in patients dementia are unknown. We investigated the clinical changes Alzheimer's disease other dementias, evaluated caregivers' distress during quarantine.
A recently devised test of motor cortex excitability (short latency afferent inhibition) was shown to be sensitive the blockade muscarinic acetylcholine receptors in healthy subjects. The authors used this assess cholinergic transmission patients with AD.The evaluated short inhibition 15 AD and compared data those 12 age-matched controls.Afferent reduced (mean responses +/- SD 85.7% 15.8% size) controls 45.3% 16.2% size; p < 0.001, unpaired t-test). Administration a single oral dose...
In order to characterize the neuropsychologic profile of patients with hypoxic-hypercapnic chronic obstructive pulmonary disease (COPD), performance 36 COPD 69 +/- 10 yr age (mean SD) on 19 tests exploring eight cognitive domains was compared those 29 normal adults (69 7 age), 20 elderly (78 2 26 Alzheimer-type dementia (72 6 and 28 multi-infarct (MID) (70 8 age). The discriminant analysis test scores showed that 48.5% had a specific pattern deterioration characterized by dramatic impairment...
<b>Background:</b> In vivo evaluation of cholinergic circuits the human brain has recently been introduced using a transcranial magnetic stimulation (TMS) protocol based on coupling peripheral nerve with motor cortex TMS (short latency afferent inhibition, SAI). SAI is reduced in Alzheimer’s disease (AD) and drugs enhancing transmission increase SAI. <b>Methods:</b> We evaluated whether testing, together test-retest, after single dose acetylcholinesterase (AChE) inhibitor rivastigmine, might...
The aim of this study was to investigate the neuronal network characteristics in physiological and pathological brain aging. A database 378 participants divided three groups analyzed: Alzheimer's disease (AD), mild cognitive impairment (MCI
Several studies have identified two types of sleep spindles: fast (13–15 Hz) centroparietal and slow (11–13 frontal spindles. Alterations in spindle activity been observed Alzheimer’s disease (AD) Mild Cognitive Impairment (MCI). Only few separately assessed spindles these patients showing a reduction count, but the possible local specificity this phenomenon its relation to cognitive decline severity are not clear. Moreover, density never AD/MCI. We 15 AD patients, amnesic MCI healthy...
In the study of prosopagnosia, several issues (such as specific or non-specific manifestations unitary non-unitary nature this syndrome and mechanisms underlying face recognition disorders) are still controversial. Two main sources variance partially accounting for these controversies could be qualitative differences between disorders observed in patients with prevalent lesions right left hemisphere those encroaching upon temporo-occipital (TO) (right) anterior temporal cortex. Results our...
One factor believed to impact brain resilience the pathological damage of Alzheimer's disease (AD) is so-called “cognitive reserve” (CR). A critical issue that still needs be fully understood mechanism by which environmental enrichme
Abstract Although a slowing of electroencephalographic (EEG) activity during wakefulness and –to some extent- sleep Alzheimer disease (AD) patients (i.e., increased slow-frequency activity) was documented, recent findings in healthy elderly show decreased 0.6–1 Hz slow wave (SWA) NREM, which associated to β-amyloid deposition impaired hippocampal memory consolidation. We hypothesize that the apparent contradiction may be explained by partial overlap between EEG K-Complex (KC). According this...
Abstract Free water elimination (FWE) in brain diffusion MRI has been shown to improve tissue specificity human white matter characterization both health and disease. Relative the classical tensor imaging (DTI) model, FWE is also expected increase sensitivity microstructural changes longitudinal studies. However, it not clear if these two models differ their test–retest reproducibility. This study compares a bi‐tensor model for with DTI by extending previous longitudinal‐reproducibility 3T...
Background: Family caregivers of patients with dementia are at high risk stress and burden, quarantine due to the coronavirus disease 2019 (COVID-19) pandemic may have increased psychological disturbances in this population. The current study was carried out during national lockdown declared March 2020 by Italian government as a containment measure first wave is nationwide survey on impact COVID-19 mental health informal caregivers. Methods: Eighty-seven centers evenly distributed territory...
Patients with Alzheimer's disease (AD) undergo a slowing of waking electroencephalographic (EEG) rhythms since prodromal stages, which could be ascribed to poor sleep quality. We examined the relationship between wake and alterations by assessing EEG activity during (pre-sleep/post-sleep) wakefulness in AD, mild cognitive impairment (MCI) healthy controls. AD MCI show high latency less slow-wave sleep. Reduced sigma characterizes non-rapid eye movement (NREM) sleep, reflecting spindles loss....
More than 10 million Europeans show signs of mild cognitive impairment (MCI), a transitional stage between normal brain aging and dementia memory disorder. The path MCI takes can be divergent; while some maintain stability or even revert to norms, alarmingly, up half the cases progress within 5 years. Current diagnostic practice lacks necessary screening tools identify those at risk progression. European patient experience often involves long journey from initial eventual diagnosis dementia....
Background The meaning of post-stroke depression is controversial. Aims To investigate the hypothesis that major (PSD) may be due to organic factors (left frontal lesions) immediately after stroke, but psychosocial in later stages. Method We studied 153 consecutive stroke patients, categorised on basis time elapsed since lesion location and presence/absence PSD, Fifty-eight were examined first two months following 52 between four months, 43 or more. symptom profiles anatomical–clinical...
Background: Central nervous system involvement occurs in most patients with myotonic dystrophy type 1 (DM1): mental retardation characterizes congenital forms, while a mild cognitive impairment has been described adult classic DM1.Neuropathological studies documented neurofibrillary tangles and an aberrant tau-protein expression brain tissues of animal models DM1.Objectives: To characterize the pattern dysfunction occurring DM1 to analyze genotypephenotype correlations DM1. Methods:We...
Abstract Owing to the lack of instruments specifically constructed study emotional and affective disorders stroke patients, nature post-stroke depression (PSD) remains controversial. With this in mind, authors a new scale, Post-Stroke Depression Rating Scale (PSDS) which takes into account series symptoms problems commonly observed depressed patients. The PSDS Hamilton (HDS) were administered group 124 who had been classified, on basis DSM III-R diagnostic criteria, following categories: No...