A5081877893- Advanced MRI Techniques and Applications
- Cerebrovascular and Carotid Artery Diseases
- Cardiovascular Function and Risk Factors
- Cardiac Imaging and Diagnostics
- Cardiac Valve Diseases and Treatments
- Cardiovascular Health and Disease Prevention
- Coronary Interventions and Diagnostics
- Aortic Disease and Treatment Approaches
- Cardiomyopathy and Myosin Studies
- Congenital Heart Disease Studies
- Aortic aneurysm repair treatments
- Advanced Neuroimaging Techniques and Applications
- Elasticity and Material Modeling
- Pulmonary Hypertension Research and Treatments
- Ultrasound Imaging and Elastography
- Atherosclerosis and Cardiovascular Diseases
- Advanced X-ray and CT Imaging
- Intracranial Aneurysms: Treatment and Complications
- Medical Imaging Techniques and Applications
- Photoacoustic and Ultrasonic Imaging
- Dementia and Cognitive Impairment Research
- Medical Image Segmentation Techniques
- MRI in cancer diagnosis
- Cardiovascular Disease and Adiposity
- Ultrasound and Hyperthermia Applications
Karolinska Institutet
2018-2025
Massachusetts Institute of Technology
2020-2024
Karolinska University Hospital
2023-2024
University of Michigan–Ann Arbor
2023
Linköping University
2023
University of Auckland
2023
University of California, San Francisco
2023
IIT@MIT
2021
KTH Royal Institute of Technology
2018-2020
Danderyds sjukhus
2019
Chronic type B aortic dissection (TBAD) is associated with poor long-term outcome, and accurate risk stratification tools remain lacking. Pressurization of the false lumen (FL) has been recognized as central in promoting growth. Several surrogate imaging-based metrics have proposed to assess FL hemodynamics; however, their relationship enlarging dimensions remains unclear. We investigated association between growth three cardiovascular magnetic resonance (CMR)-derived pressurization:...
Rapamycin is an inhibitor of the mechanistic target rapamycin (mTOR) protein kinase, and preclinical data demonstrate that it a promising candidate for general gero- neuroprotective treatment in humans. Results from mouse models Alzheimer's disease have shown beneficial effects rapamycin, including preventing or reversing cognitive deficits, reducing amyloid oligomers tauopathies normalizing synaptic plasticity cerebral glucose uptake. The "Evaluating Treatment Disease using Positron...
4D Flow Magnetic Resonance Imaging (4D MRI) is a non-invasive technique for volumetric, time-resolved blood flow quantification. However, apparent trade-offs between acquisition time, image noise, and resolution limit clinical applicability. In particular, in regions of highly transient flow, coarse temporal can hinder accurate capture physiologically relevant variations. To overcome these issues, post-processing techniques using deep learning have shown promising results to enhance...
Carotid endarterectomy for symptomatic carotid stenosis is recommended patients with >70% stenosis, but not in those <50%. Because non-significant, low-degree stenoses may still cause strokes, refined risk stratification necessary, which could be improved by assessing biological features of plaque instability. To challenge risk-stratification based on luminal narrowing, we compared plaques from (<50%) vs high-degree (>70%) and explored potential mechanisms behind instability stenoses....
Abstract Many cardiovascular diseases lead to local increases in relative pressure, reflecting the higher costs of driving blood flow. The utility this biomarker for stratifying severity disease has thus driven development methods measure these pressures. While intravascular catheterisation remains most direct measure, its invasiveness limits clinical application many instances. Non-invasive Doppler ultrasound estimates have partially addressed gap; however only provide pressure a range...
Introduction: Atrial fibrillation (AF) is a widespread cardiac arrhythmia that commonly affects the left atrium (LA), causing it to quiver instead of contracting effectively. This behavior triggered by abnormal electrical impulses at specific site in atrial wall. Catheter ablation (CA) treatment consists isolating this driver burning surrounding tissue restore sinus rhythm (SR). However, evidence suggests CA can concur formation blood clots promoting coagulation near heat source and regions...
The increasing prevalence of finite element (FE) simulations in the study atherosclerosis has spawned numerous inverse FE methods for mechanical characterization diseased tissue vivo. Current approaches are however limited to either homogenized or simplified material representations. This paper presents a novel method account heterogeneity and nonlinearity recovery constitutive behavior using imaging data acquired at differing intravascular pressures by incorporating interfaces between...
Abstract Left ventricular outflow tract (LVOT) obstruction is a relatively common consequence of transcatheter mitral valve replacement (TMVR). Although LVOT associated with heart failure and adverse remodelling, its effects upon left hemodynamics remain poorly characterised. This study uses validated computational models to identify the degree that causes significant changes in after TMVR. Seven TMVR patients underwent personalised flow simulations based on pre-procedural imaging data....
Vascular pressure differences are established risk markers for a number of cardiovascular diseases. Relative pressures are, however, often driven by turbulence-induced flow fluctuations, where conventional non-invasive methods may yield inaccurate results. Recently, we proposed novel method non-turbulent flows, νWERP, utilizing the concept virtual work-energy to accurately probe relative through complex branching vasculature. Here, present an extension this approach turbulent flows: νWERP-t....
Abstract Fatal cerebrovascular events are often caused by rupture of atherosclerotic plaques. However, rupture-prone plaques distinguished their internal composition rather than degree luminal narrowing, and conventional imaging techniques might thus fail to detect such culprit lesions. In this feasibility study, we investigate the potential ultrasound shear wave elastography (SWE) vulnerable carotid plaques, evaluating group velocity frequency-dependent phase velocities as novel biomarkers...
Intracardiac blood flow is driven by differences in relative pressure, and assessing these critical understanding cardiac disease. Non-invasive image-based methods exist to assess however, the complex dynamically moving fluid domain of intracardiac space limits assessment. Recently, we proposed a method, νWERP, utilizing an auxiliary virtual field probe pressure through complex, previously inaccessible domains. Here present extension νWERP for assessments, solving over sub-domains...
Hemodynamic alterations are indicative of cerebrovascular disease. However, the narrow and tortuous cerebrovasculature complicates image-based assessment, especially when quantifying relative pressure. Here, we present a systematic evaluation pressure mapping, investigating accuracy routinely used reduced Bernoulli (RB), extended unsteady (UB), full-field virtual work-energy (
Coronary computed tomography angiography (CCTA) provides 3D information on obstructive coronary artery disease, but cannot fully visualize high-resolution features within the vessel wall. Intravascular imaging, in contrast, can spatially resolve atherosclerotic cross sectional slices, is limited capturing relationships between each slice. Co-registering CCTA and intravascular images enables a variety of clinical research applications time consuming user-dependent. This due to suffering from...
The pathophysiology of atherosclerotic lesions, including plaque rupture triggered by mechanical failure the vessel wall, depends directly on morphology-modulated response. complex interplay between lesion morphology and structural behaviour can be studied with high-fidelity computational modelling. However, construction three-dimensional (3D) heterogeneous models is challenging, most previous work focusing two-dimensional geometries or single-material compositions. Addressing these...
Changes in cardiovascular hemodynamics are closely related to the development of aortic regurgitation (AR), a type valvular heart disease. Metrics derived from blood flows used indicate AR onset and evaluate its severity. These metrics can be non-invasively obtained using four-dimensional (4D) flow magnetic resonance imaging (MRI), where accuracy is primarily dependent on spatial resolution. However, insufficient resolution often results limitations 4D MRI complex hemodynamics. To address...
Abstract Aims Non-invasive estimation of mean pulmonary artery pressure (mPAP) by cardiovascular magnetic resonance (CMR) four-dimensional (4D) flow analysis has shown excellent agreement with invasive right heart catheterization. However, clinical application is limited relatively long scan times. Therefore, the aim this study was to evaluate accuracy and time reduction compressed sensing (CS) accelerated acquisition for mPAP estimation. Methods results Patients (n = 51) referred CMR at 1.5...
Guidance for preventing myocardial infarction and ischemic stroke by tailoring treatment individual patients with atherosclerosis is an unmet need. Such development may be possible computational modeling. Given the multifactorial biology of atherosclerosis, modeling must based on complete biological networks that capture protein-protein interactions estimated to drive disease progression. Here, we aimed develop a clinically relevant scale model calibrate it patient data, use simulate...
4D Flow Magnetic Resonance Imaging (4D MRI) is a non-invasive measurement technique capable of quantifying blood flow across the cardiovascular system. While practical use limited by spatial resolution and image noise, incorporation trained super-resolution (SR) networks has potential to enhance quality post-scan. However, these efforts have predominantly been restricted narrowly defined domains, with exploration how SR performance extends system; task aggravated contrasting hemodynamic...
Ultrasound elastography has shown potential for improved plaque risk stratification. However, no clear consensus exists on what output metric to use, or imaging parameters would render optimal differentiation. For this reason we developed a combined ex vivo and in vitro setup, which the ability differentiate phantom plaques of varying stiffness was evaluated as function geometry, push location, plane, analysed wave speed metric. The results indicate that group velocity phase ⩾1 kHz showed...
Shear wave elastography (SWE) is a promising technique for characterizing carotid plaques and assessing local arterial stiffness. The mechanical stress to which the tissue subjected during SWE using acoustic radiation force (ARF), leading strain at certain rate, still relatively unknown. Because increasingly used applications where could potentially lead significant consequences, it important understand risks of SWE-induced rate. aim this study was investigate safety in terms induced...