A5020878478- Congenital Heart Disease Studies
- Cardiac Valve Diseases and Treatments
- Cardiovascular Function and Risk Factors
- Aortic Disease and Treatment Approaches
- Cardiac Imaging and Diagnostics
- Pulmonary Hypertension Research and Treatments
- Coronary Artery Anomalies
- Cardiac Arrhythmias and Treatments
- Congenital heart defects research
- Aortic aneurysm repair treatments
- Advanced MRI Techniques and Applications
- Cardiac Structural Anomalies and Repair
- Radiation Dose and Imaging
- Cardiovascular Issues in Pregnancy
- Ultrasound in Clinical Applications
- Birth, Development, and Health
- Congenital Diaphragmatic Hernia Studies
- Viral Infections and Immunology Research
- Cardiovascular and Diving-Related Complications
- Obesity, Physical Activity, Diet
- Anatomy and Medical Technology
- Cardiovascular Effects of Exercise
- Pericarditis and Cardiac Tamponade
- Surgical Simulation and Training
- Cardiovascular Disease and Adiposity
Istituto di Fisiologia Clinica
2016-2025
National Research Council
2015-2025
Fondazione Toscana Gabriele Monasterio
2015-2024
Regione Toscana
2009-2024
Czech Academy of Sciences, Institute of Physiology
2024
Hospital de Santa Cruz
2021
University of Mosul
2020
University of Messina
2015
National Academies of Sciences, Engineering, and Medicine
2012
Scuola Superiore Sant'Anna
2006
To evaluate the impact of 3D printed models (3D models) on surgical planning in complex congenital heart disease (CHD).A prospective case-crossover study involving 10 international centres and 40 patients with CHD (median age 3 years, range 1 month-34 years) was conducted. Magnetic resonance imaging computed tomography were used to acquire segment cardiovascular anatomy. Models fabricated by fused deposition modelling polyurethane filament, dimensions compared medical images. Decisions after...
The seventh Committee on "Biological Effects of Ionizing Radiation" (BEIR VII, 2006) underlines "the need studies infants who are exposed to diagnostic radiation because catheters have been placed in their hearts".To determine the lifetime attributable risk (LAR) cancer associated with estimated cumulative radiological dose 59 children (42 male, age 2.8+/-3.2 years) complex congenital heart disease, and assess chromosomal DNA damage after cardiac catheterisation procedures. Methods In all...
The purpose of our study was to investigate the potential contribution germline mutations in NOTCH1, GATA5 and TGFBR1 TGFBR2 genes a cohort Italian patients with familial Bicuspid Aortic Valve (BAV).All coding exons including adjacent intronic as well 5' 3' untranslated (UTR) sequences GATA5, were screened by direct gene sequencing 11 index (8 males; age = 42 ± 19 years) BAV defined two or more affected members.Two novel mutations, missense nonsense mutation (Exon 5, p.P284L; Exon 26,...
Medical radiological exposure is associated with an additional risk of cancer. Children repaired congenital heart disease (CHD) are theoretically at a relatively greater cancer as the can be intensive in these patients. Chromosomal aberrations test (CA) and micronucleus assay (MN) peripheral blood lymphocytes biomarkers chromosomal damage intermediate endpoints carcinogenesis.The frequency CA MN was assessed three groups patients: Group I, 32 exposed patients (17 males, age=15.5+/-8.3 years)...
Cardiovascular magnetic resonance (CMR) and computed tomography (CCT) are advanced imaging modalities that recently revolutionized the conventional diagnostic approach to congenital heart diseases (CHD), supporting echocardiography often replacing cardiac catheterization. This is second of two complementary documents, endorsed by experts from Working Group Italian Society Pediatric Cardiology College Cardiac Radiology Medical Interventional Radiology, aimed at giving updated indications on...
Patent foramen ovale (PFO) has been identified as a potential risk factor for cerebrovascular ischemia. Procoagulant mutations may increase the and impact choice of appropriate therapy secondary prevention. We evaluated prevalence 2 most common genetic factors thromboembolism, V Leiden (G1691A) prothrombin G20210A, in young PFO patients who were referred percutaneous transcatheter closure their PFO.Ninety-seven (50 men; mean+/-SD age, 40.9+/-10.0 years) with first-ever events before age 55...
Lung ultrasound is gaining consensus for the diagnosis of some pulmonary conditions. Pulmonary complications are common in pediatric cardiac surgery. However, its use remains limited this setting. Our aim was to test feasibility lung following surgery and compare chest X-ray findings, assessing whether may provide additional information.One hundred thirty-eight examinations were performed 79 children (median age 9.3 months) at different time points after For each hemithorax, 3 areas...
Background Cardiac MRI plays a critical role in the management of thalassemic patients. No accurate biventricular reference values are available. Purpose To establish ranges for normal left ventricular (LV) and right (RV) volumes ejection fraction (EF) LV mass normalized to body surface area (BSA), age, gender large cohort well‐treated beta‐thalassemia major (β‐TM) patients without heart damage using multiparametric MRI. Study Type Retrospective/cohort study. Population In all, 251 β‐TM with...
The importance of experimental setups able to reproduce cardiac functions was well established in the field clinical innovations. mock circulatory loops acquired rising relevance, and possibility have a complete reproduction different specific fluid dynamic conditions within setup is pivotal. A system with enough versatility physiologic range both flows pressures required. This study describes design versatile composed by custom pulsatile left ventricular pump 3D-printed loop for vitro...
Background Among cardiovascular diseases, adult patients with congenital heart disease represent a population that has been continuously increasing, which is mainly due to improvement of the pathophysiological framing, including development surgical and reanimation techniques. However, approximately 20% these will require surgery in adulthood 40% cases necessitate reintervention for residual defects or sequelae childhood surgery. In this field, cardiac rehabilitation (CR) postsurgical phase...
Abstract We sought to evaluate the potential clinical role of 4D-flow cardiac magnetic resonance (CMR)-derived energetics and flow parameters in a cohort patients’ post-Fontan palliation. In patients with Fontan circulation who underwent 4D-Flow CMR, streamlines distribution was evaluated, as well CMR-derived kinetic energy (KE) loss (EL) normalized by volume. EL/KE index marker efficiency also calculated. Cardiopulmonary exercise test (CPET) performed subgroup patients. The population study...