We present a novel framework for the fluid dynamics analysis of healthy subjects and patients affected by ascending thoracic aorta aneurysm (aTAA). Our aim is to obtain indications about effect bulge on hemodynamic environment at different enlargements. Three-dimensional (3D) surface models defined from with aTAA, selected surgical repair, were generated. A representative shape model both pathological groups has been identified. morphing technique based radial basis functions (RBF) was...

The multimodal and multidomain registration of medical images have gained increasing recognition in clinical practice as a powerful tool for fusing leveraging useful information from different imaging techniques fields such cardiology orthopedics. Image could be challenging process, it strongly depends on the correct tuning parameters. In this paper, robustness accuracy landmarks-based approach been presented five cardiac image datasets. study is based 3D Slicer software focused computed...

Heart diseases are one of the commonest causes death worldwide. These include valve pathologies such as stenosis, regurgitation, failure and similar, for which usually a substitution procedure is required. Different prosthesis alternatives (both biological artificial) nowadays available in heart surgery panorama, but there still issues aspects to improve. The principal requirements prostheses an efficient fluid dynamic function long-term durability without need anticoagulation therapy,...

In the context of aortic hemodynamics, uncertainties affecting blood flow simulations hamper their translational potential as supportive technology in clinics. Computational fluid dynamics (CFD) under rigid-walls assumption are largely adopted, even though aorta contributes markedly to systemic compliance and is characterized by a complex motion. To account for personalized wall displacements hemodynamics simulations, moving-boundary method (MBM) has been recently proposed computationally...

Computational hemodynamics has become increasingly important within the context of precision medicine, providing major insight in cardiovascular pathologies. However, finding appropriate compromise between speed and accuracy remains challenging computational for an extensive use decision making. For example, ascending thoracic aorta, interactions blood aortic wall must be taken into account sake accuracy, but these fluid structure (FSI) induce significant costs, especially when tissue...

The importance of experimental setups able to reproduce cardiac functions was well established in the field clinical innovations. mock circulatory loops acquired rising relevance, and possibility have a complete reproduction different specific fluid dynamic conditions within setup is pivotal. A system with enough versatility physiologic range both flows pressures required. This study describes design versatile composed by custom pulsatile left ventricular pump 3D-printed loop for vitro...

Background: Penetrating aortic ulcer (PAU) is an acute syndrome characterized by a high rupture risk. There are several PAU-treatment procedures indicated for the management of this pathology associated with different effects on vessel morphology and hemodynamics. A deep evaluation types treatment may be helpful in decision making. Computational Fluid Dynamics (CFD) powerful tool detailed inspection cardiovascular diseases. The aim work was to implement comparative analysis based CFD two...

Abstract Left atrial appendage occlusion (LAAO) is a percutaneous procedure to prevent thromboembolism in patients affected by fibrillation. Despite its demonstrated efficacy, the LAA morphological complexity hinders procedure, resulting postprocedural drawbacks (device‐related thrombus and peri‐device leakage). Local anatomical features may cause difficulties device's positioning affect effectiveness of implant. The current work proposes detailed FE model LAAO useful investigate implant...

Cardiovascular diseases are the leading cause of death in western countries. Robotic surgery recently emerged as a confirmed strategy cardiovascular field, especially thanks to improvement soft robotics. These techniques have demonstrated their potential terms speed execution and precision. In this context, deeper knowledge material properties blood vessels is required, for computational robotics applications. A constitutive model including contribution collagen fibers families needed take...

This work presents the development of a Hybrid Mock Circulatory Loop (HMCL) to simulate hemodynamics at patient-specific level in terms both 3D geometry and inlet/outlet boundary conditions.Clinical data have been processed define morphological functional settings. A piston pump is used impose parametric flow rate profile inlet hemodynamic circuit. In order guarantee physiological pressure conditions, specific hybrid chamber system including real-time control has designed implemented. The...

The analysis of mechanobiology arterial tissues remains an important topic research for cardiovascular pathologies evaluation. In the current state art, gold standard to characterize tissue mechanical behavior is represented by experimental tests, requiring harvesting ex-vivo specimens. recent years though, image-based techniques in vivo estimation stiffness were presented. aim this study define a new approach provide local distribution stiffness, estimated as linearized Young's Modulus,...

The venoarterial extracorporeal membrane oxygenation (VA-ECMO) is a widely adopted procedure to provide oxygenated blood support in patients who underwent cardiac shock. current work presents study define correlation between VA-ECMO level and both systemic pressure arterial perfusion. In this work, numerical approach defined on patient-specific aortic geometry validate trend more complete case also investigate the behavior of mixing zone. particular, morphological data from computed...

Cardiovascular diseases remain a leading cause of morbidity and mortality worldwide require extensive investigation through

Abdominal Aortic Aneurysm (AAA) is a balloon-like dilatation that can be life-threatening if not treated. Fabricating patient-specific AAA models beneficial for in-vitro investigations of hemodynamics, as well pre-surgical planning and training, testing the effectiveness different interventions, or developing new surgical procedures. The current direct additive manufacturing techniques cannot simultaneously ensure flexibility transparency required by some applications. Therefore, casting are...

Purpose . The left atrial appendage (LAA) is responsible for thrombus formation in patients with fibrillation. evaluation of both LAA function and morphology crucial the patient characterization preprocedural planning closure intervention. Despite availability 3D imaging modalities, current standard image analysis based on manual delineation contours 2D views. Methods In this study, a comprehensive approach full tomographic dataset by surface extraction processing (3D-S) presented. proposed...