A5016127946- Intracerebral and Subarachnoid Hemorrhage Research
- Alzheimer's disease research and treatments
- Cerebrovascular and genetic disorders
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Acute Ischemic Stroke Management
- Neurosurgical Procedures and Complications
- MRI in cancer diagnosis
- Kruppel-like factors research
- Dementia and Cognitive Impairment Research
- Advanced Neuroimaging Techniques and Applications
- Spinal Hematomas and Complications
- Advanced Glycation End Products research
- Cerebrospinal fluid and hydrocephalus
Leiden University Medical Center
2020-2024
Massachusetts General Hospital
2024
Harvard University
2024
Vascular amyloid β (Aβ) accumulation is the hallmark of cerebral angiopathy (CAA). The composition cerebrospinal fluid (CSF) CAA patients may serve as a diagnostic biomarker CAA. We studied potential peptides Aβ38, Aβ40, Aβ42, and Aβ43 in with sporadic (sCAA), hereditary Dutch-type (D-CAA), Alzheimer disease (AD).
Cerebral Amyloid Angiopathy (CAA) disease course is highly variable even in hereditary forms. Sex may be a possible modifying factor. We investigated biological sex differences clinical and magnetic resonance imaging-markers sporadic (sCAA) Dutch-type CAA (D-CAA).
Neurofilament light chain (NFL) is a biomarker for neuroaxonal damage and glial fibrillary acidic protein (GFAP) reactive astrocytosis. Both processes occur in cerebral amyloid angiopathy (CAA), but studies investigating the potential of NFL GFAP as markers CAA are lacking. We aimed to investigate biomarkers astrocytosis CAA.
Enlarged perivascular spaces (PVS) in the centrum semiovale are an important marker of Cerebral Amyloid Angiopathy (CAA) and thought to reflect brain clearance dysfunction. However, current golden standard for assessing PVS is limited a unilateral, single slice, qualitative analysis, which has disadvantage strong ceiling effect. We aim introduce whole-brain volume fraction (PVSvf) measurement assess cross-sectional longitudinal PVSvf differences between pre-symptomatic symptomatic Dutch-type...
Knowledge on the short-term progression of cerebral amyloid angiopathy (CAA) is important for clinical practice and design treatment trials. We investigated 1-year CAA-related MRI markers in sporadic (sCAA) Dutch-type hereditary (D-CAA). Participants were included from 2 prospective cohort studies. 3T-MRI was performed at baseline after 1 year. assessed macrobleeds, microbleeds (CMBs), cortical superficial siderosis (cSS), convexity subarachnoid hemorrhages (cSAHs), white matter...
BACKGROUND: The temporal ordering of biomarkers for cerebral amyloid angiopathy (CAA) is important their use in trials and the understanding pathological cascade CAA. We investigated presence abnormality most common largest (pre)symptomatic Dutch-type hereditary CAA (D-CAA) cohort to date. METHODS: included cross-sectional data from participants with D-CAA controls without CAA-related small vessel disease markers on 3T-MRI, cerebrovascular reactivity functional 7T-MRI (fMRI) amyloid-β 40 42...
Background and Purpose: Although evidence accumulates that the cerebellum is involved in cerebral amyloid angiopathy (CAA), cerebellar superficial siderosis not considered to be a disease marker. The objective of this study investigate frequency its relation hemorrhagic magnetic resonance imaging markers patients with sporadic Dutch-type hereditary CAA deep perforating arteriopathy–related intracerebral hemorrhage. Methods: We recruited from 3 prospective Tesla studies scored hemorrhages....
Abstract Background Neuropsychiatric symptoms (NPS) may affect cognition, but their burden in cerebral amyloid angiopathy (CAA), one of the main causes intracerebral hemorrhage (ICH) and dementia elderly, remains unclear. We investigated NPS, with emphasis on apathy irritability sporadic (sCAA) Dutch-type hereditary (D-)CAA. Methods included patients sCAA (pre)symptomatic D-CAA, controls from four prospective cohort studies. assessed NPS per group, stratified for history ICH, using...
Background: Men with cerebral amyloid angiopathy (CAA) may have an earlier onset of intracerebral hemorrhage and a more hemorrhagic disease course compared to women. In this cohort study, we investigated sex differences in histopathological markers associated amyloid-β burden cognitively impaired individuals patients CAA, using neuropathological data from two autopsy databases. Methods: First, presence parenchymal (Thal score) vascular (CAA severity the National Alzheimer’s Coordinating...
Peak width of skeletonized mean diffusivity (PSMD) is an emerging diffusion-MRI based marker to study subtle early alterations white matter microstructure. We assessed PSMD over the clinical continuum in Dutch-type hereditary CAA (D-CAA) and its association with other CAA-related MRI-markers cognitive symptoms. included (pre)symptomatic D-CAA mutation-carriers calculated from data. Associations between PSMD-levels, performance were linear regression models. 59 participants (25/34...
Background and Purpose— To determine whether migraine, which has often been described as an inaugural manifestation in monogenic cerebrovascular syndromes, is associated with cerebral amyloid pathology, we assessed migraine its correlation magnetic resonance imaging markers Hereditary Dutch-Type Cerebral Amyloid Angiopathy (D-CAA or Hemorrhage With Amyloidosis-Dutch type). Methods— All D-CAA mutation carriers who visited our clinic between 2012 2018 were included. Migraine was diagnosed by...
Whether certain activities can trigger spontaneous intracerebral hemorrhage (ICH) remains unknown. Insights into factors that vessel rupture resulting in ICH improves knowledge on the pathophysiology of ICH. We assessed potential and their risk for onset.We included consecutive patients diagnosed with between July 1, 2013, December 31, 2019. interviewed exposure to 12 (eg, Valsalva maneuvers) (hazard) period soon before onset normal these year used case-crossover design calculate relative...
We observed subarachnoid cerebrospinal fluid (CSF) hyperintensities at non-contrast 7-tesla (T) fluid-attenuated inversion recovery (FLAIR) MRI, frequently topographically associated with cortical superficial siderosis (cSS), in participants cerebral amyloid angiopathy (CAA). To systemically evaluate these CSF we investigated their frequency and anatomical temporal relationship cSS on 7T 3T MRI hereditary Dutch-type CAA (D-CAA), sporadic (sCAA), non-CAA controls.CAA were included from two...
Abstract Background Cerebral amyloid angiopathy (CAA) is a disease caused by the accumulation of amyloid-beta protein and major cause intracerebral hemorrhage (ICH) vascular dementia in elderly. The presence vessel wall may induce chronic state cerebral inflammation activating astrocytes, microglia, pro-inflammatory substances. Minocycline, an antibiotic tetracycline family, known to modulate inflammation, gelatinase activity, angiogenesis. These processes are suggested be key mechanisms CAA...
The aim of the present study is to explore whether using 7 Tesla magnetic resonance imaging, additional brain changes can be observed in hereditary cerebral hemorrhage with amyloidosis-Dutch type (HCHWA-D) patients as compared established imaging features sporadic amyloid angiopathy.The local institutional review board approved this prospective cohort study. In all cases, informed consent was obtained. This parallel conducted between 2012 and 2014. We performed T2*-weighted at presymptomatic...
The revised Boston criteria v2.0 for cerebral amyloid angiopathy (CAA) add two radiological markers to the existing criteria: severe visible perivascular spaces in centrum semiovale and white matter hyperintensities (WMHs) a multispot pattern. This study aims determine sensitivity of updated mutation carriers with Dutch-type hereditary CAA (D-CAA) an early later disease stage.
Background and aim To investigate whether a striped occipital cortex intragyral hemorrhage, two markers recently detected on ultra-high-field 7-tesla-magnetic resonance imaging in hereditary cerebral amyloid angiopathy (CAA), also occur sporadic CAA (sCAA) or non-sCAA intracerebral hemorrhage (ICH). Methods We performed patients with probable sCAA non-sCAA-ICH. Striped (linear hypointense stripes perpendicular to the cortex) (hemorrhage restricted juxtacortical white matter of one gyrus)...
Cortical calcifications have been reported in patients with cerebral amyloid angiopathy (CAA), although their prevalence and pathophysiology are unknown. We investigated the frequency of on computed tomography, association intracerebral hemorrhage (ICH) coexistence a striped pattern occipital cortex reflecting microcalcifications ultra-high-field 7T-magnetic resonance imaging Dutch-type hereditary CAA (D-CAA) sporadic CAA.We included D-CAA mutation carriers proven APP (amyloid precursor...
Cerebral amyloid angiopathy (CAA) is a cerebrovascular disease affecting the small arteries in brain with hallmark depositions of amyloid-β vessel wall, leading to cognitive decline and intracerebral hemorrhage (ICH). An emerging MRI marker for CAA cortical superficial siderosis (cSS) as it strongly related risk (recurrent) ICH. Current assessment cSS mainly done on T2*- weighted using qualitative score consisting 5 categories severity which hampered by ceiling effects. Therefore, need more...
Cerebral Amyloid Angiopathy (CAA) is characterized by cerebrovascular amyloid-β accumulation leading to hallmark cortical MRI markers, such as vascular reactivity, but white matter also affected. By studying the relationship in different disease stages of Dutch-type CAA (D-CAA), we tested relation between reactivity and microstructural integrity loss. In a cross-sectional study D-CAA, 3 T was performed with Blood-Oxygen-Level-Dependent (BOLD) fMRI upon visual activation assess diffusion...
It is unclear why cerebral small vessel disease (SVD) leads to lacunar stroke in some and non-lobar intracerebral hemorrhage (ICH) others. We investigated differences MRI markers of SVD patients with or ICH.We included from two prospective cohort studies either (RUN DMC) ICH (FETCH). Differences (white matter hyperintensities [WMH], lacunes, microbleeds [CMB]) between groups were univariable tests; multivariable logistic regression analysis, adjusted for age, sex, vascular risk factors;...
Aim To investigate whether there is a topographical and temporal pattern of index recurrent intracerebral hemorrhages (ICH) in Dutch-type hereditary Cerebral Amyloid Angiopathy (D-CAA) to increase our understanding on CAA-related ICH development. Methods We included patients with DNA confirmed D-CAA or history ≥1 lobar first-degree relative D-CAA. Topographical was studied by location (proportion frontal/parietal/temporal/occipital; infra/supratentorial occurrence ratios lobe volume) volume...
<b><i>Introduction:</i></b> Dutch-type cerebral amyloid angiopathy (D-CAA) is an autosomal dominant hereditary form of CAA causing intracerebral hemorrhage (ICH) and cognitive decline. The age onset ICH in D-CAA mutation carriers strikingly variable ranges from late thirties up to 70 years. We investigated the presence genetic anticipation assessed influence parental at sex on offspring. <b><i>Methods:</i></b> included (potential) our...