A5038728530- Parkinson's Disease Mechanisms and Treatments
- Organ Donation and Transplantation
- Intensive Care Unit Cognitive Disorders
- Neurological disorders and treatments
- Palliative Care and End-of-Life Issues
- Neuroinflammation and Neurodegeneration Mechanisms
- Alzheimer's disease research and treatments
- Genetic Neurodegenerative Diseases
- Intracerebral and Subarachnoid Hemorrhage Research
- Traumatic Brain Injury and Neurovascular Disturbances
- Grief, Bereavement, and Mental Health
- Anesthesia and Neurotoxicity Research
- Long-Term Effects of COVID-19
- Neurological diseases and metabolism
- Cardiac Arrest and Resuscitation
- Organ Transplantation Techniques and Outcomes
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Respiratory Support and Mechanisms
- Neurosurgical Procedures and Complications
- Cerebrovascular and genetic disorders
- Restless Legs Syndrome Research
- Anesthesia and Sedative Agents
- Botulinum Toxin and Related Neurological Disorders
- Liver Disease and Transplantation
- Tryptophan and brain disorders
Radboud University Nijmegen
2014-2024
Radboud University Medical Center
2014-2024
Leiden University Medical Center
2023
University Medical Center Utrecht
2023
Utrecht University
2023
Maastricht University
2023
Radboud Institute for Molecular Life Sciences
2020-2022
University Medical Center
2021
Streekziekenhuis Koningin Beatrix
2020
Catharina Ziekenhuis
2020
To describe the phenotype of adult patients with variant and classic ataxia-telangiectasia (A-T), to raise degree clinical suspicion for diagnosis A-T, assess a genotype-phenotype relationship mutations in ATM gene.Retrospective analysis characteristics course disease 13 A-T 9 families 6 unrelated adults mutation gene measurements protein expression kinase activity.Patients were only correctly diagnosed adulthood. They often presented extrapyramidal symptoms childhood, whereas cerebellar...
Differentiating between Parkinson's disease (PD) and atypical Parkinsonism (AP) is clinically relevant but challenging. A timely correct diagnosis might result in better targeted treatment strategies, adequate patient counseling, early recognition of disease-specific complications. We aimed to investigate whether cerebrospinal fluid (CSF) concentrations α-synuclein are additional diagnostic value. examined 142 consecutive patients with parkinsonism, mean duration 39.7 mo (Parkinson's (PD), n...
Vascular amyloid β (Aβ) accumulation is the hallmark of cerebral angiopathy (CAA). The composition cerebrospinal fluid (CSF) CAA patients may serve as a diagnostic biomarker CAA. We studied potential peptides Aβ38, Aβ40, Aβ42, and Aβ43 in with sporadic (sCAA), hereditary Dutch-type (D-CAA), Alzheimer disease (AD).
Cognitive deficits are increasingly recognized as a long-term sequela of severe COVID-19. The underlying processes and molecular signatures associated with these neurological sequalae COVID-19 remain largely unclear, but may be related to systemic inflammation-induced effects on the brain. We studied inflammation-brain interplay its relation development cognitive impairment in patients who survived Trajectories inflammation neuroaxonal damage blood biomarkers during ICU admission were...
<b>Background:</b> Balance impairment is a frequently encountered problem in patients with Parkinson's disease. A profound balance disorder, however, an atypical feature. <b>Methods:</b> Tandem gait performance (10 consecutive tandem steps) was judged 36 disease and 49 parkinsonism. <b>Results:</b> Only 9 (18%) parkinsonism had fully normal (not single side step) as opposed to 33 (92%) Analysis for the subgroup of duration <3 years yielded same diagnostic accuracy. <b>Conclusions:</b> has...
Background and purpose Rhabdomyolysis is a medical emergency characterized by acute skeletal muscle breakdown with sudden rise subsequent fall of serum creatine kinase (CK) levels. events are provoked exposure to external triggers, possibly in combination an increased genetic susceptibility. We aimed describe comprehensively the triggers potentially pathogenic variants implicated rhabdomyolysis Methods performed retrospective single‐center study, including total 1302 patients CK level...
Abstract We investigated whether cerebrospinal fluid (CSF) analysis discriminates between idiopathic Parkinson's disease (PD; n = 35) and multiple system atrophy (MSA; 30). The median CSF concentration of the neurotransmitter metabolites 5‐hydroxyindolacetic acid (5‐HIAA) 3‐methoxy‐4‐hydroxyphenylethyleneglycol (MHPG) was reduced significantly (49‐70%) in MSA compared to PD. In contrast, several brain‐specific proteins (tau, neuron‐specific enolase, myelin basic protein) were elevated...
Delirium is a complex and multifactorial condition associated with long-term cognitive decline. Due to the strong links between systemic inflammation, delirium dementia we hypothesized that responses within brain in patients who develop could show biochemical overlap Alzheimer's disease (AD). In this observational study analyzed protein expression signatures cerebrospinal fluid (CSF) from 15 infectious compared these 29 AD, 30 without non-infectious controls free of neurological disease. A...
Long-term cognitive performance data in former critically ill COVID-19 patients are sparse. Current evidence suggests that decline is related to neuroinflammation, which might be attenuated by anti-inflammatory therapies. The objective of this prospective cohort study was long term outcomes following severe and the relation Prospective observational survived an intensive care unit (ICU) admission due COVID-19. Six months after hospital discharge, we extensively assessed both functioning...
Differentiating idiopathic late-onset cerebellar ataxia (ILOCA) from due to the subtype of multiple-system atrophy (MSA-C) can be difficult in early stages diseaseThe authors analyzed levels various CSF biomarkers 27 patients with MSA-C and 18 ILOCA obtained cut-off points for each potential biomarker differentiate ILOCA.Increased neurofilament light chain (NFL) heavy (NFHp35) decreased neurotransmitter metabolites homovanillic acid (HVA), 5-hydroxyindoleaceticacid (5-HIAA),...
In this study we investigated the cerebrospinal fluid (CSF) levels of neurofilament light (NFL) and heavy chain (NFHp35), total tau (t-tau), glial fibrillary acidic protein (GFAP) to detect disease specific profiles in sporadic Creutzfeldt Jakob
Differentiating dementia with Lewy bodies (DLB) from Alzheimer's Disease (AD) can be difficult because of the substantial overlap in clinical features. Since deficits serotonergic and dopaminergic pathways seem more pronounced DLB patients, we
Various signs on routine brain MRI can help differentiate between Parkinson's disease (PD) and the various forms of atypical parkinsonism (AP). Here, we evaluate what contributes to clinical diagnosis, in both early advanced stages. We performed a prospective observational study 113 patients with parkinsonism, but without definite diagnosis upon inclusion. At baseline, received structured interview, comprehensive standardized neurological assessment, MRI. The silver standard was made after 3...
We report a case series of patients with prolonged but reversible unconsciousness after coronavirus disease 2019 (COVID-19)-related severe respiratory failure.A who were admitted to the intensive care unit due COVID-19-related acute failure is described.After cessation sedatives, described cases all showed comatose state. Diagnostic neurologic workup did not show signs devastating brain injury. The clinical pattern awakening started early eye opening without obeying commands and persistent...
Predicting time to death in controlled donation after circulatory (cDCD) donors following withdrawal of life-sustaining treatment (WLST) is important but poses a major challenge. The aim this study determine factors predicting within 60 minutes WSLT and validate previously developed prediction models. In single-center retrospective study, we used the data 92 potential cDCD donors. Multivariable regression analysis demonstrated that absent cough-, corneal reflex, lower morphine dosage,...