A5049724481- Intracerebral and Subarachnoid Hemorrhage Research
- Alzheimer's disease research and treatments
- Cerebrovascular and genetic disorders
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Dementia and Cognitive Impairment Research
- Neurosurgical Procedures and Complications
- Acute Ischemic Stroke Management
- Cerebrospinal fluid and hydrocephalus
- MRI in cancer diagnosis
- Advanced Neuroimaging Techniques and Applications
- Ethics in Clinical Research
- Kruppel-like factors research
- Spinal Hematomas and Complications
- Innovations in Medical Education
- Traumatic Brain Injury and Neurovascular Disturbances
- Ethics in medical practice
- Advanced Glycation End Products research
Leiden University Medical Center
2020-2025
Prion-like transmission of amyloid-ß through cadaveric dura, decades after neurosurgical procedures, has been hypothesized as an iatrogenic cause cerebral amyloid angiopathy (CAA). We investigated new and previously described patients to assess the clinical profile, radiological features, outcome this presumed CAA-subtype (iCAA). Patients were collected from our prospective lobar hemorrhage CAA database (n=251) with presenting hospital between 2008 2022. In addition, we identified iCAA 2...
Vascular amyloid β (Aβ) accumulation is the hallmark of cerebral angiopathy (CAA). The composition cerebrospinal fluid (CSF) CAA patients may serve as a diagnostic biomarker CAA. We studied potential peptides Aβ38, Aβ40, Aβ42, and Aβ43 in with sporadic (sCAA), hereditary Dutch-type (D-CAA), Alzheimer disease (AD).
Abstract Background and purpose An increasing number of cases iatrogenic cerebral amyloid angiopathy (CAA) have now been reported worldwide. Proposed diagnostic criteria require a history medical intervention with potential for amyloid‐β transmission, example those using cadaveric dura mater or requiring instrumentation the brain spinal cord. Clinical presentation occurs after an appropriate latency (usually three four decades); to date, most patients CAA had ‘early‐onset’ disease (compared...
Abstract Background and purpose Patients who underwent red blood cell (RBC) transfusion from donors later developed multiple spontaneous intracerebral hemorrhages (ICHs) have recently been identified to increased risk of ICH themselves. This was hypothesized be related iatrogenic cerebral amyloid angiopathy (iCAA) transmission. Two cases are presented had RBC as an infant with CAA at a relatively young age decades later. Method Cases were by prospectively asking all patients our outpatient...
Background We aimed to describe neuroimaging features, clinical profiles and long-term outcomes in patients with iatrogenic cerebral amyloid angiopathy (iCAA). Methods performed a systematic literature search for case series of iCAA included individual their longitudinal data this pooled cohort study. Patients meeting modified version the Queen Square criteria were included. Baseline follow-up MRIs centrally analysed markers CAA using validated rating scales. Results 51 (68.6% male, median...
Iatrogenic cerebral amyloid angiopathy (iCAA) is a recently identified clinico-neuroradiological syndrome associated with medical procedures, particularly neurosurgical treatments involving cadaveric dura mater (e.g., Lyodura). iCAA can manifest as intracerebral hemorrhages, focal seizures, and cognitive impairment, the risk following exposure currently unknown. We aim to evaluate of developing in patients who underwent childhood treatment Lyodura compared those did not. This retrospective...
Enlarged perivascular spaces (PVS) in the centrum semiovale are an important marker of Cerebral Amyloid Angiopathy (CAA) and thought to reflect brain clearance dysfunction. However, current golden standard for assessing PVS is limited a unilateral, single slice, qualitative analysis, which has disadvantage strong ceiling effect. We aim introduce whole-brain volume fraction (PVSvf) measurement assess cross-sectional longitudinal PVSvf differences between pre-symptomatic symptomatic Dutch-type...
Knowledge on the short-term progression of cerebral amyloid angiopathy (CAA) is important for clinical practice and design treatment trials. We investigated 1-year CAA-related MRI markers in sporadic (sCAA) Dutch-type hereditary (D-CAA). Participants were included from 2 prospective cohort studies. 3T-MRI was performed at baseline after 1 year. assessed macrobleeds, microbleeds (CMBs), cortical superficial siderosis (cSS), convexity subarachnoid hemorrhages (cSAHs), white matter...
BACKGROUND: The temporal ordering of biomarkers for cerebral amyloid angiopathy (CAA) is important their use in trials and the understanding pathological cascade CAA. We investigated presence abnormality most common largest (pre)symptomatic Dutch-type hereditary CAA (D-CAA) cohort to date. METHODS: included cross-sectional data from participants with D-CAA controls without CAA-related small vessel disease markers on 3T-MRI, cerebrovascular reactivity functional 7T-MRI (fMRI) amyloid-β 40 42...
Abstract Background Patients with sporadic cerebral amyloid angiopathy (sCAA) frequently report cognitive or neuropsychiatric symptoms. The aim of this study is to investigate whether in patients sCAA, impairment and symptoms are associated a cerebrospinal fluid (CSF) biomarker profile Alzheimer’s disease (AD). Methods In cross-sectional study, we included participants sCAA dementia- stroke-free, age- sex-matched controls, who underwent lumbar puncture, brain MRI, assessments,...
Abstract Background Neuropsychiatric symptoms (NPS) may affect cognition, but their burden in cerebral amyloid angiopathy (CAA), one of the main causes intracerebral hemorrhage (ICH) and dementia elderly, remains unclear. We investigated NPS, with emphasis on apathy irritability sporadic (sCAA) Dutch-type hereditary (D-)CAA. Methods included patients sCAA (pre)symptomatic D-CAA, controls from four prospective cohort studies. assessed NPS per group, stratified for history ICH, using...
Peak width of skeletonized mean diffusivity (PSMD) is an emerging diffusion-MRI based marker to study subtle early alterations white matter microstructure. We assessed PSMD over the clinical continuum in Dutch-type hereditary CAA (D-CAA) and its association with other CAA-related MRI-markers cognitive symptoms. included (pre)symptomatic D-CAA mutation-carriers calculated from data. Associations between PSMD-levels, performance were linear regression models. 59 participants (25/34...
Background and Purpose: The Edinburgh computed tomography genetic criteria enable diagnosis of cerebral amyloid angiopathy (CAA) associated lobar intracerebral hemorrhage (ICH) but have not been validated in living patients. We assessed the sensitivity patients with acute ICH due to Dutch-type hereditary CAA; a pure form CAA. Methods: retrospectively analyzed tomography-scans from cohort consecutive CAA who presented ≥1 episode(s) at Leiden University Medical Center. Presence subarachnoid...
Whether certain activities can trigger spontaneous intracerebral hemorrhage (ICH) remains unknown. Insights into factors that vessel rupture resulting in ICH improves knowledge on the pathophysiology of ICH. We assessed potential and their risk for onset.We included consecutive patients diagnosed with between July 1, 2013, December 31, 2019. interviewed exposure to 12 (eg, Valsalva maneuvers) (hazard) period soon before onset normal these year used case-crossover design calculate relative...
Cerebral amyloid angiopathy (CAA) is a main cause of cognitive dysfunction in the elderly. We investigated specific profiles, function stage before intracerebral hemorrhage (ICH), and association between magnetic resonance imaging (MRI) based cerebral small vessel disease (cSVD) burden CAA because data on these topics are limited.
The revised Boston criteria v2.0 for cerebral amyloid angiopathy (CAA) add two radiological markers to the existing criteria: severe visible perivascular spaces in centrum semiovale and white matter hyperintensities (WMHs) a multispot pattern. This study aims determine sensitivity of updated mutation carriers with Dutch-type hereditary CAA (D-CAA) an early later disease stage.
Abstract Background and Purpose Data on health‐related quality of life (HRQoL) mood in cerebral amyloid angiopathy (CAA), a disease characterized by stroke cognitive decline, are limited. We aimed to investigate the impacted domains life, value‐based HRQoL prevalence depression anxiety patients with CAA. Methods conducted cross‐sectional study sporadic (s)CAA, lobar dominant mixed CAA hypertensive arteriopathy (mixed CAA‐HTA), or Dutch‐type hereditary (D‐)CAA, from prospective outpatient...
Cerebral Amyloid Angiopathy (CAA) is characterized by cerebrovascular amyloid-β accumulation leading to hallmark cortical MRI markers, such as vascular reactivity, but white matter also affected. By studying the relationship in different disease stages of Dutch-type CAA (D-CAA), we tested relation between reactivity and microstructural integrity loss. In a cross-sectional study D-CAA, 3 T was performed with Blood-Oxygen-Level-Dependent (BOLD) fMRI upon visual activation assess diffusion...
We investigated whether quantitative electroencephalography (qEEG) correlates with cognition and cortical superficial siderosis (cSS) in cerebral amyloid angiopathy.
<b><i>Introduction:</i></b> Dutch-type cerebral amyloid angiopathy (D-CAA) is an autosomal dominant hereditary form of CAA causing intracerebral hemorrhage (ICH) and cognitive decline. The age onset ICH in D-CAA mutation carriers strikingly variable ranges from late thirties up to 70 years. We investigated the presence genetic anticipation assessed influence parental at sex on offspring. <b><i>Methods:</i></b> included (potential) our...
Abstract Background Amyloid‐β (Aβ) deposits are the main pathological hallmark of cerebral amyloid angiopathy (CAA) and Alzheimer’s disease (AD). Vascular in CAA mainly consist Aβ 40 , whereas 42 is predominant peptide parenchymal plaques AD. The diagnostic accuracy other species remains understudied. We aimed to investigate biomarker potential various peptides for differentiation sporadic (sCAA) hereditary Dutch‐type (D‐CAA) from AD controls. Method Cerebrospinal fluid (CSF) 38 43 levels...