Hideo Hara
A5016713260- Intracerebral and Subarachnoid Hemorrhage Research
- Acute Ischemic Stroke Management
- Particle physics theoretical and experimental studies
- High-Energy Particle Collisions Research
- Alzheimer's disease research and treatments
- Quantum Chromodynamics and Particle Interactions
- T-cell and Retrovirus Studies
- Thyroid Disorders and Treatments
- Neurosurgical Procedures and Complications
- Neuroinflammation and Neurodegeneration Mechanisms
- Dementia and Cognitive Impairment Research
- Cerebrovascular and Carotid Artery Diseases
- Peripheral Neuropathies and Disorders
- Neurological Disease Mechanisms and Treatments
- Genetic Neurodegenerative Diseases
- Parkinson's Disease Mechanisms and Treatments
- Particle Detector Development and Performance
- Myasthenia Gravis and Thymoma
- Vector-Borne Animal Diseases
- Erythrocyte Function and Pathophysiology
- Pituitary Gland Disorders and Treatments
- Neurological and metabolic disorders
- Neurological disorders and treatments
- Computational Drug Discovery Methods
- Cerebrovascular and genetic disorders
Saga University
2014-2024
International University of Health and Welfare
2022-2023
University College London
2014-2023
Fukuoka International University
2022-2023
RIKEN BioResource Research Center
2019-2023
National Hospital for Neurology and Neurosurgery
2014-2023
Union Hospital
2023
Fujian Medical University
2023
Hokkaido University
2023
Biomedical Research Institute
2022
Transverse momentum spectra for charged hadrons and neutral pions in the range 1 GeV/c<p(T)<5 GeV/c have been measured by PHENIX experiment at RHIC Au+Au collisions root square[s(NN)] = 130 GeV. At high p(T) from peripheral nuclear are consistent with scaling p+p average number of binary nucleon-nucleon collisions. The central significantly suppressed when compared to binary-scaled expectation, also similarly collisions, indicating a novel nuclear-medium effect energies.
Identified ${\ensuremath{\pi}}^{+/\ensuremath{-}}$, ${K}^{+/\ensuremath{-}}$, $p$, and $\overline{p}$ transverse momentum spectra at midrapidity in $\sqrt{{s}_{\mathrm{NN}}}\phantom{\rule{0ex}{0ex}}=\phantom{\rule{0ex}{0ex}}130\phantom{\rule{0ex}{0ex}}\mathrm{GeV}\phantom{\rule{0ex}{0ex}}\mathrm{Au}+\mathrm{Au}$ collisions were measured by the PHENIX experiment RHIC as a function of collision centrality. Average momenta increase with number participating nucleons similar way for all particle...
We present results for the charged-particle multiplicity distribution at midrapidity in Au-Au collisions square root of [s(NN)] = 130 GeV measured with PHENIX detector RHIC. For 5% most central we find dN(ch)/d eta(vertical line eta 0) 622+/-1(stat)+/-41(syst). The results, analyzed as a function centrality, show steady rise particle density per participating nucleon centrality.
<h3>Objective:</h3> We investigated whether the topography of MRI-visible perivascular spaces (PVS) is associated with markers specific underlying small vessel disease, including cerebral microbleed (CMB) distribution, in neurologically healthy adults. <h3>Methods:</h3> analyzed baseline data an ongoing Japanese population-based cohort study. PVS were rated basal ganglia (BG-PVS) and centrum semiovale (CSO-PVS) on axial T2-weighted MRI using a validated rating scale (score 0–4). BG-PVS...
Two-particle azimuthal correlation functions are presented for charged hadrons produced in Au+Au collisions at the Relativistic Heavy Ion Collider (sqrt [s(NN)]=130 GeV). The measurements permit determination of elliptic flow without event-by-event estimation reaction plane. extracted values (v2) show significant sensitivity to both collision centrality and transverse momenta emitted hadrons, suggesting rapid thermalization relatively strong velocity fields. When scaled by eccentricity zone...
Transverse momentum spectra and yields of hadrons are measured by the PHENIX collaboration in $\text{Au}+\text{Au}$ collisions at $\sqrt{{s}_{NN}}=130\phantom{\rule{0.3em}{0ex}}\text{GeV}$ Relativistic Heavy Ion Collider. The time-of-flight resolution allows identification pions to transverse momenta $2\phantom{\rule{0.3em}{0ex}}\text{GeV}∕c$ protons antiprotons $4\phantom{\rule{0.3em}{0ex}}\text{GeV}∕c$. yield rises approximately linearly with number nucleons participating collision, while...
Transverse momentum spectra of electrons from Au+Au collisions at square root[s(NN)] = 130 GeV have been measured midrapidity by the PHENIX experiment Relativistic Heavy Ion Collider. The show an excess above background photon conversions and light hadron decays. electron signal is consistent with that expected semileptonic decays charm. yield dN(e)/dy for p(T) > 0.8 GeV/c 0.025+/-0.004(stat)+/-0.010(syst) in central collisions, corresponding charm cross section 380+/-60(stat)+/-200(syst)...
Two-pion correlations in square root[s(NN)] = 130 GeV Au+Au collisions at RHIC have been measured over a broad range of pair transverse momentum k(T) by the PHENIX experiment RHIC. The dependent radii are similar to results from heavy-ion 4.1, 4.9, and 17.3 GeV, whereas longitudinal radius increases monotonically with beam energy. ratio outwards sidewards (R(out)/R(side)) is consistent unity independent k(T).
Immunotherapy with Abeta is expected to bring great improvement for Alzheimer disease (AD). However, clinical trials have been suspended because of meningoencephalitics, which accompanied lymphocytic infiltration. We developed an oral vaccine AD a recombinant adeno-associated viral vector carrying cDNA (AAV/Abeta). The reduces the amount deposited without infiltration in APP transgenic (Tg2576) mice. In present study, Tg2576 mice showed progressive cognitive impairments novel object...
The first measurement of energy produced transverse to the beam direction at Relativistic Heavy-Ion Collider Brookhaven National Laboratory is presented. midrapidity density per participating nucleon rises steadily with number participants, closely paralleling rise in charged-particle density, such that <E(T)>/<N(ch)> remains relatively constant as a function centrality. calculated via Bjorken's prescription for 2% most central Au+Au collisions square root[s(NN)] = 130 GeV least epsilon(Bj)...
<h3>Importance</h3> Repeat expansion of CGG in<i>LRP12</i>has been identified as the causative variation oculopharyngodistal myopathy (OPDM). However, to our knowledge, clinicopathologic features OPDM with repeat in<i>LRP12</i>(hereafter referred OPDM_LRP12) remain unknown. <h3>Objective</h3> To identify and characterize patients OPDM_LRP12<i>.</i> <h3>Design, Setting, Participants</h3> This case series included 208 a clinical or diagnosis oculopharyngeal muscular dystrophy (OPDM) from...
Abstract Background and purpose An increasing number of cases iatrogenic cerebral amyloid angiopathy (CAA) have now been reported worldwide. Proposed diagnostic criteria require a history medical intervention with potential for amyloid‐β transmission, example those using cadaveric dura mater or requiring instrumentation the brain spinal cord. Clinical presentation occurs after an appropriate latency (usually three four decades); to date, most patients CAA had ‘early‐onset’ disease (compared...
We present results on the measurement of $\ensuremath{\Lambda}$ and $\overline{\ensuremath{\Lambda}}$ production in $\mathrm{A}\mathrm{u}+\mathrm{A}\mathrm{u}$ collisions at $\sqrt{{s}_{NN}}=130\text{ }\text{ }\mathrm{G}\mathrm{e}\mathrm{V}$ with PHENIX detector Relativistic Heavy Ion Collider. The transverse momentum spectra were measured for minimum bias 5% most central events. $\overline{\ensuremath{\Lambda}}/\ensuremath{\Lambda}$ ratios are constant as a function ${p}_{T}$ number...
Identification of the localization human T lymphotrophic virus type I (HTLV-I) proviral DNA in central nervous system (CNS) is crucial to understanding pathogenesis HTLV-I-associated myelopathy (HAM)/tropical spastic paraparesis (TSP) pathogenesis. We have developed a sensitive detection method, called two-step polymerase chain reaction (PCR) situ hybridization, which enabled us detect HTLV-I paraffin-embedded spinal cord tissue sections from HAM/TSP patients. was detected only nucleus...
Brain microbleeds (MBs) are considered to be associated with cognitive decline and can pathologically topographically classified as cerebral amyloid angiopathy-related (located in lobar regions) hypertensive microangiopathy-related deep regions). We examined whether different effects on global function might seen distributions of MBs.A total 1279 adults without neurological disorders were studied prospectively. Subjects divided into 4 groups: without-MBs group; both areas (diffuse group)....
Cerebral microbleeds are associated with the risks of ischemic stroke and intracranial hemorrhage, causing clinical dilemmas for antithrombotic treatment decisions. We aimed to evaluate hemorrhage in patients atrial fibrillation treated vitamin K antagonists, direct oral anticoagulants, antiplatelets, combination therapy (i.e. concurrent anticoagulant antiplatelet).
Distributions of event-by-event fluctuations the mean transverse momentum and energy near mid-rapidity have been measured in Au+Au collisions at $\sqrt{{s}_{\mathrm{NN}}}=130 \mathrm{GeV}$ Relativistic Heavy-Ion Collider. By comparing distributions to what is expected for statistically independent particle emission, magnitude nonstatistical determined be consistent with zero. Also, no significant nonrandom are observed. constructing a fluctuation model two event classes that preserve...
A new oral vaccine for Alzheimer's disease was developed using recombinant adeno-associated virus vector carrying Aβ cDNA (AAV/Aβ). Oral administration of the without adjuvant induced expression and secretion Aβ1–43 or Aβ1–21 in ep
ABSTRACT Background Depression, parkinsonism, and hypoventilation (Perry syndrome) or familial motor neuron disease have been linked to mutations in dynactin P150 Glued ( DCTN1 ). Methods We employed genealogic, clinical, neurologic, MRI investigations, as well analysis of genes implicated parkinsonism. Cellular transfection, immunocytochemistry, immunoprecipitation wild‐type (WT) mutant were also performed. Results A novel heterozygous mutation, c.156T>G, encoding p.Phe52Leu, segregates...
We herein report the case of a 38-year-old man who developed parkinsonism 4 years after ingesting glyphosate. The patient presented with right-sided bradykinesia and cogwheel rigidity without autonomic symptoms. Magnetic resonance imaging brain [123I]-metaiodobenzylguanidine myocardial scintigraphy were normal. A drastic response to levodopa presence levodopa-induced dyskinesia strong non-motor symptoms seen in this patient. considered that young-onset atypical was associated history...