A5021706644- Dementia and Cognitive Impairment Research
- Intracerebral and Subarachnoid Hemorrhage Research
- Acute Ischemic Stroke Management
- Stroke Rehabilitation and Recovery
- Alzheimer's disease research and treatments
- Neurological Disease Mechanisms and Treatments
- Cerebrovascular and Carotid Artery Diseases
- Trauma and Emergency Care Studies
- Bipolar Disorder and Treatment
- Neurological diseases and metabolism
- Immune Cell Function and Interaction
- Amyotrophic Lateral Sclerosis Research
- Frailty in Older Adults
- Retinopathy of Prematurity Studies
- Cardiac Arrest and Resuscitation
- Cancer Treatment and Pharmacology
- Cardiovascular Health and Disease Prevention
- Traumatic Brain Injury Research
- Neurosurgical Procedures and Complications
- Glioma Diagnosis and Treatment
- Respiratory viral infections research
- Viral Infections and Vectors
- Immunotherapy and Immune Responses
- Neuroblastoma Research and Treatments
- Atrial Fibrillation Management and Outcomes
Cedars-Sinai Medical Center
2025
National Neuroscience Institute
2017-2024
St. Luke's Medical Center
2020
Sansum Medical Clinic
2004
Background:Hypertension and white matter hyperintensities (WMH) are mutually associated risk factors for cognitive impairment. However, age may modify the associations between hypertension WMH, their links to Objective:We evaluated interaction hyper tension on age-stratified of WMH with cognition. Methods:Key measures include systolic blood pressure (SBP), (modified Fazekas visual ratings cranial MRI), Montreal Cognitive Assessment (MoCA). Participants (N = 488) prodromal mild dementia were...
Importance Cerebral small vessel disease (SVD) is associated with various cerebrovascular outcomes, but data on sex differences in SVD are scarce. Objective To investigate whether the frequency, severity, and distribution of cerebral microbleeds (CMB), other markers magnetic resonance imaging (MRI), outcomes differ by sex. Design, Setting, Participants This cohort study used pooled individual patient from Microbleeds International Collaborative Network, including patients 38 prospective...
With emerging amyloid therapies, documentation of the patient's status to confirm etiology a clinical diagnosis is warranted prior instituting amyloid-based therapy. The Multimer Detection System-Oligomeric Amyloid-β (MDS-OAβ) noninvasive blood-based biomarker utilized measure Aβ oligomerization tendency. We determined difference in MDS-OAβ ratio across groups: (a) no cognitive impairment or subjective (NCI/SCI), (b) Alzheimer's disease (AD), (c) non-AD, and (d) mixed disease-Vascular...
Small vessel disease (SVD) and Alzheimer's (AD) frequently coexist; however, it remains unclear how they collectively affect cognition. We investigated associations between SVD AD biomarkers, namely amyloid, tau, neurodegeneration (ATN) in young onset dementia (YOD) explored ATN interact to 80 YOD individuals were recruited from a memory clinic. burden (SVD+) was operationalized as score >1 on the Staals scale measured using cerebrospinal fluid (CSF). SVD+ associated with lower CSF Aβ1-42 (B...
Background: Chronic cerebrovascular pathology accelerates the incidence of poststroke dementia (PSD). Whether risk PSD varies according to different types chronic remains unclear. Objectives: We investigated whether is associated with a unique pattern interactions between pathologies and acute stroke lesions. Materials Method: In this case-control study mild patients (n=185), cases included who developed at 6-month follow-up, controls remained nondemented 6 months, matched on prestroke...
<b><i>Background:</i></b> Compared to Western populations, familial frontotemporal lobar degeneration (FTLD) is rare among Asians. Progranulin (GRN) gene mutation, which a major cause of FTLD, likewise rare. We present family with FTLD from the Philippines an autosomal dominant pattern inheritance and GRN mutation briefly review reports mutations in Asia. <b><i>Case Presentation:</i></b> The proband 66 years old progressive nonfluent aphasia...
Cognitive rehabilitation programs for dementia are becoming more essential to maintain cognitive and functional performance by engaging stimulating the patients in addition medication. Not everyone will benefit from however due differences activity preference or background. The different gender, education level example may affect how readily accept engage with programs. In this study, we would like investigate long term outcomes as well interaction effect of gender levels a multi-domain...
The presence of small vessel disease (SVD) is associated with cognitive impairment. However, among the many components SVD, contribution CMBs to impairment remain elusive. Our aim was determine if cerebral microbleeds (CMBs) contribute global and specific domains in addition that contributed by other measures burden an Asian cohort. Subjects participating a multimodal imaging study having diagnosis mild (MCI), Alzheimer's (AD) or healthy control (HC) were recruited. CMB quantified on SWI...
Non-pharmacological treatment has been shown to be beneficial in the maintenance of cognitive function. However, usefulness and acceptance such a programme for Asian patients not adequately studied. The OWOW! Cognitive stimulation was conceived by adapting holistic approach encompassing physical, social aspects wellbeing person with dementia. Programme structured as an eight week comprising three hour long, once weekly sessions. Each session included following components: physical exercise,...
Hypertensive vasculopathy and cerebral amyloid angiopathy are the two main etiologies of microbleeds (CMBs). Determining underlying cause will open doors to preventive curative strategies in future. Subjects from multimodal imaging study clinic cohort with diagnoses SCI, MCI, AD, VaD were recruited. CMBs quantified on SWI GRE images using MARS. Other markers small vessel disease assessed SVD score evaluation FLAIR T2W images. All MRI quantifications performed by a single neurologist blinded...
Hypertensive vasculopathy and cerebral amyloid angiopathy are the two main etiologies of microbleeds (CMBs). Determining underlying cause will open doors to preventive curative strategies in future. Subjects from multimodal imaging study clinic cohort with diagnoses SCI, MCI, AD, VaD were recruited. CMBs quantified on SWI GRE images using MARS. Other markers small vessel disease assessed SVD score evaluation FLAIR T2W images. All MRI quantifications performed by a single neurologist blinded...
The presence of small vessel disease (SVD) is associated with cognitive impairment. However, among the many components SVD, contribution CMBs to impairment remain elusive. Our aim was determine if cerebral microbleeds (CMBs) contribute global and specific domains in addition that contributed by other measures burden an Asian cohort. Subjects participating a multimodal imaging study having diagnosis mild (MCI), Alzheimer's (AD) or healthy control (HC) were recruited. CMB quantified on SWI...
Abstract Background: Cerebrovascular disease (CVD) and Alzheimer’s (AD) frequently coexist however the mechanism by which they collectively affect cognition remains unclear, particularly in young onset dementia (YOD). We investigated associations between CVD AD biomarkers, namely amyloid, tau neurodegeneration (ATN) YOD, explored how ATN interact to cognition. Methods: 80 YOD individuals with mild dementia, mean age 57.73 (SD = 6.01) years were recruited from a memory clinic. MRI visual...
Abstract Background Clinicians use neuropsychological assessment to screen individuals for cognitive impairment since it more convenient and can detect impaired parts of cognition provide early treatment. This study is aimed differentiate the performance on Alzheimer’s Disease Assessment Scale – Cognition (ADAS‐Cog) among older adults with normal MCI. Method The sample composed 302 participants aged ≥60 years old who met score 25 in Mini‐mental status examination (MMSE). Psychologists would...
Abstract Background The Asian population has been found to be at a higher risk of developing dementia compared other races due the high prevalence vascular factors. Utilization different modalities that manage these factors is focus this study in order prevent progression among senior citizens with mild cognitive impairment. Method Community‐based participants MCI were recruited join FINOMAIN Study. They divided into control and intervention groups, which INDAK (dance therapy) shall given....
Abstract Background Cognitive impairment in older adults is multifactorial and chronic hence, a complex intervention that can be integrated community programs major consideration for it to impact society. Designing challenging intensified with lack of research resources support its development. In this paper, we aim delve on experiences Filipino investigators designing overcoming challenges interventions elderly mild cognitive (MCI). Methods As part study process evaluation, gathered...