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A5006866914- Acute Ischemic Stroke Management
- Intracerebral and Subarachnoid Hemorrhage Research
- Stroke Rehabilitation and Recovery
- Neurosurgical Procedures and Complications
- Atrial Fibrillation Management and Outcomes
- Advanced Neuroimaging Techniques and Applications
- Cerebrospinal fluid and hydrocephalus
- Venous Thromboembolism Diagnosis and Management
- Osteoarthritis Treatment and Mechanisms
- Long-Term Effects of COVID-19
- Rheumatoid Arthritis Research and Therapies
- Neurological and metabolic disorders
- Spondyloarthritis Studies and Treatments
- COVID-19 and healthcare impacts
- Global Health and Surgery
- Neurological Disease Mechanisms and Treatments
- Cerebrovascular and Carotid Artery Diseases
- Dementia and Cognitive Impairment Research
National Hospital for Neurology and Neurosurgery
2019-2024
University College London Hospitals NHS Foundation Trust
2017-2024
University College London
2017-2024
Biomedical Research Institute
2022
Hospital de Sant Pau
2022
University of Bristol
2000
Bristol Royal Infirmary
2000
Cerebral microbleeds are associated with the risks of ischemic stroke and intracranial hemorrhage, causing clinical dilemmas for antithrombotic treatment decisions. We aimed to evaluate hemorrhage in patients atrial fibrillation treated vitamin K antagonists, direct oral anticoagulants, antiplatelets, combination therapy (i.e. concurrent anticoagulant antiplatelet).
Cerebral amyloid angiopathy (CAA), a common cause of intracerebral hemorrhage (ICH), is diagnosed using the Boston criteria including magnetic resonance imaging (MRI) biomarkers (cerebral microbleeds (CMBs) and cortical superficial siderosis (cSS). The simplified Edinburgh include computed tomography (CT) (subarachnoid extension (SAE) finger-like projections (FLPs)). underlying mechanisms diagnostic accuracy CT compared to MRI CAA are unknown.We included 140 survivors spontaneous lobar...
Importance Cerebral small vessel disease (SVD) is associated with various cerebrovascular outcomes, but data on sex differences in SVD are scarce. Objective To investigate whether the frequency, severity, and distribution of cerebral microbleeds (CMB), other markers magnetic resonance imaging (MRI), outcomes differ by sex. Design, Setting, Participants This cohort study used pooled individual patient from Microbleeds International Collaborative Network, including patients 38 prospective...
Abstract Introduction Diffusion tensor imaging (DTI) can assess the structural integrity of corticospinal tract (CST) in vivo. We aimed to investigate whether CST DTI metrics after intracerebral haemorrhage (ICH) are associated with 6-month functional outcome and improve predictive performance existing ICH score. Methods retrospectively included 42 patients performed within 5 days deep supratentorial spontaneous ICH. Ipsilesional-to-contralesional ratios were calculated for fractional...
Adverse non-motor outcomes are common after acute stroke and likely to substantially affect quality of life, yet few studies have comprehensively assessed their prevalence, patterns, predictors across multiple health domains.
The COVID-19 pandemic and related social isolation measures are likely to have adverse consequences on community healthcare provision outcome after acute illnesses treated in hospital, including stroke. We aimed evaluate the impact of patient-reported health outcomes hospital admission for
Small vessel disease (SVD) causes most spontaneous intracerebral haemorrhage (ICH) and is associated with widespread microstructural brain tissue disruption, which can be quantified via diffusion tensor imaging (DTI) metrics: mean diffusivity (MD) fractional anisotropy (FA). Little known about the impact of whole-brain alterations after SVD-related ICH. We aimed to investigate: (1) association between DTI metrics functional outcome ICH; (2) predictive ability these compared pre-existing ICH...
In patients with ischemic stroke (IS) or transient attack (TIA) and cortical superficial siderosis (cSS), there are few data regarding the risk of future cerebrovascular events also about benefits safety antithrombotic drugs for secondary prevention. We investigated associations cSS in recent IS TIA.
Acute spontaneous intracerebral haemorrhage is a devastating form of stroke. Prognostication after ICH may be influenced by clinicians' subjective opinions. To evaluate predictions 6-month outcome for patients in neurocritical care using the modified Rankin Scale (mRS) and compare these to actual outcome. We included first 48 h 52 adults with compared descriptive statistics multilevel binomial logistic regression. 35/52 (66%) had poor (mRS 4–6); 19/52 (36%) died. 324 were included. For good...
<h3>Background</h3> Stroke incidence and mortality is increasing in low-to-middle income countries. This trend translates locally to Queen Elizabeth Central Hospital (QECH) Blantyre Malawi; where stroke already the third highest cause of fifth most common presentation hospital. <h3>Aim</h3> To develop an international partnership improve care, primarily by setting up a unit; through this, we hope clinical services, training research platform. <h3>Findings</h3> Potential areas for UK-Malawi...