A5002895383- Circadian rhythm and melatonin
- Sleep and related disorders
- Sleep and Wakefulness Research
- Sleep and Work-Related Fatigue
- Heart Rate Variability and Autonomic Control
- Maternal Mental Health During Pregnancy and Postpartum
- Child Nutrition and Feeding Issues
- Dietary Effects on Health
- Tuberculosis Research and Epidemiology
- Bipolar Disorder and Treatment
- Diagnosis and treatment of tuberculosis
- Mental Health Research Topics
- Migraine and Headache Studies
- Non-Invasive Vital Sign Monitoring
- Impact of Light on Environment and Health
- Neuroscience of respiration and sleep
- Tryptophan and brain disorders
- Ergonomics and Musculoskeletal Disorders
- Mycobacterium research and diagnosis
- Spaceflight effects on biology
- Psychological and Temporal Perspectives Research
- Medical Research and Treatments
- EEG and Brain-Computer Interfaces
- Obsessive-Compulsive Spectrum Disorders
- HIV/AIDS Research and Interventions
University of Michigan
2019-2025
Circadian (United States)
2020-2025
Michigan United
2017-2024
Chelsea and Westminster Hospital NHS Foundation Trust
2021-2024
Johns Hopkins Medicine
2024
National Institutes of Health
2024
National Heart Lung and Blood Institute
2024
Johns Hopkins Hospital
2024
Johns Hopkins University
2024
West Middlesex University Hospital
2013-2023
To provide guidelines for collecting and analyzing urinary, salivary, plasma melatonin, thereby assisting clinicians researchers in determining which method of measuring melatonin is most appropriate their particular needs facilitating the comparison data between laboratories.A modified RAND process was utilized to derive recommendations methods humans.Consensus-based are presented studies that conducted natural living environment, clinical setting, in-patient research facilities under...
A systematic literature review and meta-analyses (where appropriate) were performed the GRADE approach was used to update previous American Academy of Sleep Medicine Practice Parameters on treatment intrinsic circadian rhythm sleep-wake disorders.Available data allowed for positive endorsement (at a second-tier degree confi dence) strategically timed melatonin (for DSWPD, blind adults with N24SWD, children/ adolescents ISWRD comorbid neurological disorders), light therapy or without...
BackgroundTackling tuberculosis requires testing and treatment of latent in high-risk groups. The aim this study was to estimate the predictive values tuberculin skin test (TST) two interferon-γ release assays (IGRAs) for development active groups—ie, people recent contact with cases from high-burden countries.MethodIn prospective cohort study, we recruited participants 54 centres (eg, clinics, community settings) London, Birmingham, Leicester UK. Participants were eligible if they aged 16...
To assess the separate contributions of sleep and circadian systems to changes in cardiac autonomic nervous system (ANS) activity, 12 supine subjects participated two 26-h constant routines, which were counterbalanced separated by 1 wk. One routine did not permit sleep, whereas second allowed during their normal phase. Parasympathetic activity was assessed with respiratory sinus arrhythmia as measured from spectral analysis beat-to-beat intervals. Sympathetic primarily preejection period...
Background The aim of this study was to examine individual differences in a large sample complete melatonin profiles not suppressed by light and search for possible associations between the amount timing secretion multitude lifestyle variables. were derived from saliva samples collected every 30 minutes dim 85 healthy women men aged 18–45 years. There variability secreted with peak values ranging 2 84 pg/ml. onset ranged 18:13 00:26 hours. use hormonal birth control, reduced levels...
Phase response curves (PRCs) to melatonin exist, but none compare different doses of using the same protocol.The aim was generate a PRC 0.5 mg oral and it our previously published 3.0 generated study included two 5-d sessions in laboratory, each preceded by 7-9 d fixed sleep times. Each session started ended with phase assessment measure dim light onset (DLMO). In between were 3 an ultradian (<150 lux)/dark cycle (light:dark, 2.5:1.5).Healthy adults (16 men, 18 women) ages 42 yr participated...
Context: Both light and melatonin can be used to phase shift the human circadian clock, but phase-advancing effect of combination has not been extensively investigated.
Exogenous melatonin is increasingly used for its phase shifting and soporific effects. We generated a three pulse response curve (PRC) to exogenous (3 mg) by administering it free‐running subjects. Young healthy subjects ( n = 27) participated in two 5 day laboratory sessions, each preceded at least week of habitual, but fixed sleep. Each session started ended with assessment measure the circadian rhythm endogenous dim light using 30 min saliva samples. In between were days an ultradian...
Poor sleep quality among people with chronic low back pain appears to be related worse pain, affect, poor physical function, and catastrophizing. The causal direction between remains an open question, however, as does whether exerts effects on differently across the course of day.This daily diary study examined lagged temporal associations prior night subsequent day function catastrophizing, reverse pain-related factors quality, time during which assessment was made moderated these...
There is a need for the accurate assessment of circadian phase outside clinic/laboratory, particularly with gold standard dim light melatonin onset (DLMO). We tested novel kit designed to assist in saliva sampling at home later determination DLMO. The includes objective measures compliance requirements and half-hourly sampling. Participants were randomized one two 10-day protocols. Each protocol consisted back-to-back laboratory assessments counterbalanced order, separated by 5-day break....
By March 2020, COVID-19 forced much of the world to stay at home reduce spread disease. Whereas some health care workers transitioned working from home, many continued report work in person as essential employees. We sought explore changes sleep, health, work, and mood during stay-at-home orders.We developed a cross-sectional online survey administered workers. The assessed screen time, media exposure, diet, exercise, substance use, mood. data were collected between 28, April 29, 2020.A...
Abstract This White Paper presents the results from a workshop cosponsored by Sleep Research Society (SRS) and for on Biological Rhythms (SRBR) whose goals were to bring together sleep clinicians circadian rhythm researchers identify existing gaps in diagnosis treatment areas of high-priority research sleep–wake disorders (CRSWD). CRSWD are distinct class caused alterations time-keeping system, its entrainment mechanisms, or misalignment endogenous external environment. In these disorders,...
Obstructive sleep apnea and other disorders overlap with comorbidities associated poor outcomes related to severe acute respiratory syndrome coronavirus 2 infection. However, the prevalence of obstructive among patients hospitalized for COVID-19 relationship is poorly characterized, relevance remains unknown. The objective this study was identify pre-existing association illness.Patients infection admitted University Michigan Hospital System were included. Electronic medical records queried...
Summary The time at which the dim light melatonin onset (DLMO) occurs can be used to ensure correct timing of and/or administration in order produce desired circadian phase shifts. Sometimes however, measuring DLMO is not feasible. Here we determined if was best estimated from fixed sleep times (based on habitual times) or free ( ad libitum ) times. Young healthy sleepers n = 60) schedules slept home for 6 days. Sleep were recorded with logs verified wrist actigraphy. Half‐hourly saliva...
Jet lag is caused by a misalignment between circadian rhythms and local destination time. As humans typically take longer to re-entrain after phase advance than delay, eastward travel often more difficult westward travel. Previous strategies reduce jet have focused on shaping the perceived light-dark cycle arrival, in order facilitate shift appropriate direction. Here we tested treatments that travelers could use their prior flight. Thus, would arrive with already partially re-entrained We...
Study Objectives:To develop a practical pre-eastward flight treatment to advance circadian rhythms as much possible but not misalign them with sleep.
The length of the endogenous period human circadian clock (tau) is slightly greater than 24 hours. There are individual differences in tau, which influence phase angle entrainment to light/dark (LD) cycle, and doing so contribute morningness-eveningness. We have recently reported that tau measured subjects living on an ultradian LD cycle averaged 24.2 hours, similar using different experimental methods. Here we report racial tau. Subjects lived (1.5 hours sleep, 2.5 wake) for 3 days....