A5072352891- Systemic Lupus Erythematosus Research
- Platelet Disorders and Treatments
- Venous Thromboembolism Diagnosis and Management
- Blood Coagulation and Thrombosis Mechanisms
- Heparin-Induced Thrombocytopenia and Thrombosis
- Atrial Fibrillation Management and Outcomes
- Complement system in diseases
- Intracerebral and Subarachnoid Hemorrhage Research
- Renal Diseases and Glomerulopathies
- Blood transfusion and management
- Acute Ischemic Stroke Management
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Blood disorders and treatments
- Pregnancy and preeclampsia studies
- Cardiovascular Issues in Pregnancy
- Blood donation and transfusion practices
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Blood groups and transfusion
- Monoclonal and Polyclonal Antibodies Research
- Neurosurgical Procedures and Complications
- Hepatitis C virus research
- Liver Diseases and Immunity
- Cell Adhesion Molecules Research
- Peripheral Neuropathies and Disorders
- Cardiac Arrhythmias and Treatments
University College London
2016-2025
University College London Hospitals NHS Foundation Trust
2016-2025
Washington State University
2024
University College Hospital
2000-2024
New York State Psychiatric Institute
2019-2024
New York Psychoanalytic Society and Institute
2019-2024
South London and Maudsley NHS Foundation Trust
2022
King's College London
2022
Queen Elizabeth University Hospital
2020-2022
University of Liverpool
2020-2022
Endoplasmic reticulum (ER) stress activates a set of signaling pathways, collectively termed the unfolded protein response (UPR). The three UPR branches (IRE1, PERK, and ATF6) promote cell survival by reducing misfolded levels. also promotes apoptotic death if ER is not alleviated. How integrates its cytoprotective proapoptotic outputs to select between life or fates unknown. We found that IRE1 ATF6 activities were attenuated persistent in human cells. By contrast, PERK signaling, including...
To determine whether treatment with low dose aspirin and heparin leads to a higher rate of live births than that achieved alone in women history recurrent miscarriage associated phospholipid antibodies (or antiphospholipid antibodies), lupus anticoagulant, cardiolipin anticardiolipin antibodies).Randomised controlled trial.Specialist clinic for miscarriages.90 (median age 33 (range 22-43)) number 4 3-15)) persistently positive results antibodies.Either (75 mg daily) or 5000 U unfractionated...
Rivaroxaban is established for the treatment and secondary prevention of venous thromboembolism, but whether it useful in patients with antiphospholipid syndrome uncertain.This randomised, controlled, open-label, phase 2/3, non-inferiority trial, done two UK hospitals, included who were taking warfarin previous a target international normalised ratio 2·5. Patients randomly assigned 1:1 to continue or receive 20 mg oral rivaroxaban daily. Randomisation was centrally, stratified by centre...
British Journal of HaematologyVolume 124, Issue 4 p. 433-453 Free Access Transfusion guidelines for neonates and older children First published: 23 January 2004 https://doi.org/10.1111/j.1365-2141.2004.04815.xCitations: 267 Dr F. Boulton, National Blood Service, Southampton Centre, Oxford Road, SO16 5AF, UK. E-mail: frank.boulton@nbs.nhs.uk AboutSectionsPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text full-text accessPlease review...
BACKGROUND AND METHODS: From 1996 through 2006, 195 cases were reported as transfusion‐related acute lung injury (TRALI) to the Serious Hazards of Transfusion scheme and from 1999 onward classified by probability, using clinical features HLA and/or HNA typing. late 2003, National Blood Service provided 80 90 percent fresh‐frozen plasma (FFP) for platelet (PLT) pools male donors. RESULTS: Forty‐nine reports highly likely/probable TRALI, 51 possible/unlikely. Of 96 investigations, donor...
Cerebral microbleeds are a potential neuroimaging biomarker of cerebral small vessel diseases that prone to intracranial bleeding. We aimed determine whether presence can identify patients at high risk symptomatic haemorrhage when anticoagulated for atrial fibrillation after recent ischaemic stroke or transient attack.
To develop new antiphospholipid syndrome (APS) classification criteria with high specificity for use in observational studies and trials, jointly supported by the American College of Rheumatology (ACR) EULAR. This international multidisciplinary initiative included 4 phases: 1) Phase I, generation surveys literature review; 2) II, reduction modified Delphi nominal group technique exercises; 3) III, definition, further guidance real-world patient scenarios, weighting via consensus-based...
<h3>Objective</h3> To develop new antiphospholipid syndrome (APS) classification criteria with high specificity for use in observational studies and trials, jointly supported by the American College of Rheumatology (ACR) EULAR. <h3>Methods</h3> This international multidisciplinary initiative included four phases: (1) Phase I, generation surveys literature review; (2) II, reduction modified Delphi nominal group technique exercises; (3) III, definition, further guidance real-world patient...
<h3>Abstract</h3> <b>Objective:</b> To receive and collate reports of death or major complications transfusion blood components. <b>Design:</b> Haematologists were invited confidentially to report deaths after during October 1996 September 1998. <b>Setting:</b> Hospitals in United Kingdom Ireland. <b>Subjects:</b> Patients who died experienced serious complications, as defined below, associated with red cells, platelets, fresh frozen plasma, cryoprecipitate. <b>Main outcome measures:</b>...
Antiphospholipid antibodies (APA), lupus anticoagulant (LA) and/or anticardiolipin (ACA), are associated with thrombosis and recurrent miscarriage. We studied the outcome of 20 pregnancies in women (median age 32 years; range 23-41) APA (14 LA positive; three immunoglobulin (Ig) G ACA two IgM positive one IgG positive) history miscarriage 4; 3-11) who declined pharmacological treatment their next pregnancy. Comparison was made a cohort 100 consecutive 33 23-44) 3-10), whom no underlying...
In 1991, the Haemostasis and Thrombosis Task Force of British Society for Haematology published guidelines on testing lupus anticoagulant (LA) (Machin et al, 1991). Since then there have been major developments in our understanding nature 'antiphospholipid antibodies' (aPLs) improvements knowledge clinical course antiphospholipid syndrome. These revised prepared against this background. They cover both laboratory aspects. Although most early observations were LA anticardiolipin (aCL), it is...
Summary Thrombotic thrombocytopenic purpura (TTP) is a life‐threatening disorder and plasma exchange (PEX) remains the primary treatment modality. Twenty‐five patients with acute refractory/relapsing idiopathic TTP received rituximab in conjunction PEX because of progressive clinical disease or deterioration laboratory parameters, despite intensive standard therapy. In relapsing TTP, was started if antibody to ADAMTS‐13 (a disintegrin metalloproteinase thrombospondin motif‐13) demonstrated...
Five hundred consecutive women (median age 33 years; range 19-45) with a history of recurrent miscarriage 4; 3-16) were screened for the presence antiphospholipid antibodies (APA)-lupus anticoagulant (LA) and/or anticardiolipin (ACA). The prevalence persistently positive tests LA was 9.6% and immunoglobulin G (IgG) M (IgM) ACA 3.3 2.2% respectively. Only seven (1.4%) positive. Repeat testing, after an interval at least 8 weeks, demonstrated that only 65.7% positive, 36.6% IgG 36.0% IgM on...
Objective To study the obstetric course of women with a history recurrent miscarriage associated antiphospholipid antibodies, lupus anticoagulant and anticardiolipin treated low dose aspirin heparin. Design Prospective observational study. Setting University based tertiary referral clinic. Population One hundred fifty pregnant persistently positive tests for antibodies. Methods Lupus was detected using dilute Russell's viper venom time together platelet neutralisation procedure. IgG IgM...
Summary Between 1996 and 2005 the Serious Hazards of Transfusion (SHOT) scheme analysed 3239 reports adverse reactions events associated with transfusion labile blood components in UK. 321 (10%) related to children under 18 years 147/3239 (4·5%) infants less than 12 months age. There were 264 cases ‘incorrect component transfused’, resulting from errors at all stages chain; 26/264 suffered actual or potential morbidity. Thirty acute reactions, three delayed 20 (three fatal)...
The updated international consensus criteria for definite antiphospholipid syndrome (APS) are useful scientific clinical studies. However, there remains a need diagnostic routine use. We audited the results of antibodies (aPLs) in cohort 193 consecutive patients with aPL positivity-based testing lupus anticoagulant (LA), IgG and IgM anticardiolipin (aCL) anti-ß(2)glycoprotein-1 (aß(2)GPI). Medium/high-titre aCL/aβ(2)GPI was defined as >99th percentile. Low-titre positivity (>95(th )< 99(th)...