A5013926692- Systemic Lupus Erythematosus Research
- Vasculitis and related conditions
- Peripheral Neuropathies and Disorders
- Sarcoidosis and Beryllium Toxicity Research
- Atherosclerosis and Cardiovascular Diseases
- Liver Diseases and Immunity
- Exercise and Physiological Responses
- Celiac Disease Research and Management
- Erythrocyte Function and Pathophysiology
- Inflammatory Myopathies and Dermatomyositis
- Immune Cell Function and Interaction
- Neurological Complications and Syndromes
- Platelet Disorders and Treatments
- Autoimmune Neurological Disorders and Treatments
- Epilepsy research and treatment
- Blood groups and transfusion
- Systemic Sclerosis and Related Diseases
- Heparin-Induced Thrombocytopenia and Thrombosis
- Rheumatoid Arthritis Research and Therapies
- Monoclonal and Polyclonal Antibodies Research
- Porphyrin Metabolism and Disorders
- Hypertrophic osteoarthropathy and related conditions
- Workaholism, burnout, and well-being
- Patient-Provider Communication in Healthcare
- Connective Tissue Growth Factor Research
University of Maryland, Baltimore
2011-2025
University of Maryland Medical Center Midtown Campus
2020-2024
University of Maryland Medical Center
2022-2024
Hennepin Healthcare Research Institute
2023
University of Maryland Medical System
2013
Johns Hopkins University
1990
Johns Hopkins Bayview Medical Center
1990
<h3>Objective</h3> To develop new antiphospholipid syndrome (APS) classification criteria with high specificity for use in observational studies and trials, jointly supported by the American College of Rheumatology (ACR) EULAR. <h3>Methods</h3> This international multidisciplinary initiative included four phases: (1) Phase I, generation surveys literature review; (2) II, reduction modified Delphi nominal group technique exercises; (3) III, definition, further guidance real-world patient...
To identify factors predictive of significant neuropsychiatric (NP) damage in systemic lupus erythematosus (SLE).One hundred and thirty patients with SLE were followed at the University Maryland Lupus Clinic from 1992 until 2003. NP manifestations defined according to revised American College Rheumatology (ACR) nomenclature case definitions for NP-SLE syndromes. Disease activity was measured using Activity Index (SLEDAI), organ Systemic International Collaborating Clinics Damage SLICC/ACR...
To determine factors associated with ischemic stroke and severity in patients systemic lupus erythematosus.Between 1992 January 2005, 238 consecutive erythematosus no history of were followed-up longitudinally at the Maryland Lupus Clinic. Patients monitored quarterly for a mean 8 years after their diagnosis, 44 (19%) developed first-ever stroke. At end study, Cox proportional regression analyses used to effect baseline clinical variables relation subsequent occurrence strokes. Severe was...
To determine the factors associated with seizures in systemic lupus erythematosus (SLE).One hundred ninety-five patients SLE were followed at University of Maryland Lupus Clinics from January 1992 until June 2004. Neuropsychiatric (NP) manifestations defined according to American College Rheumatology nomenclature and case definitions for NP-SLE syndromes, using International Classification Epileptic Seizures. At end study period, 28 195 (14%) had (21 generalized convulsive, 7 partial) during...
(1) Background: Allergic disorders and systemic lupus erythematosus (SLE) are immune dysregulation conditions that increasingly prevalent, with growing evidence suggesting shared pathogenesis. (2) Results: Patients SLE have a higher risk of allergic conditions, particularly rhinitis asthma; notably, children born to mothers show an increased asthma risk. This association appears linked mechanisms involving T-helper 2 cells, IgE, human leukocyte antigen, genetic factors, environmental...
Abstract We investigated post‐ischemic hyperreactive cutaneous blood flow in patients with primary Raynaud's phenomenon and secondary to systemic sclerosis (SSc). Reactive hyperemia was measured over a locally warmed area of skin, using laser Doppler flowmeter, following 5 minutes suprasystolic occlusion flow. found that had normal compared controls. In contrast, SSc reduced levels baseline peak either the or subjects. Infusion carbaprostacyclin, potent prostacyclin analog vasodilator, did...
<h3>Background</h3> Tumor necrosis factor (TNF) inhibitors such as adalimumab, etanercept, and infliximab play an increasingly important role in the management of a variety chronic inflammatory disorders. With their increasing use, wide spectrum dermatological adverse effects, including injection site reactions development dermatitis, have been recognized. Previous studies implicated delayed-type hypersensitivity reaction mediation to etanercept. To our knowledge, there no published on...
A 51-year-old woman with dermatomyositis (DM) on chronic immunosuppressive therapy was hospitalised for evaluation of haematuria. Surprisingly, abdominal imaging demonstrated pneumoperitoneum and pneumatosis intestinalis (PI). Her examination white cell count were normal, but she subsequently developed nausea fever. Owing to concern perforation, a hemicolectomy performed. Pathology revealed PI without inflammatory, ischaemic or neoplastic features, recovered uneventfully. discontinued. Six...
Background: Aseptic meningitis is one of the most infrequent neuropsychiatric manifestations systemic lupus erythematosus (SLE) with multifactorial etiologies including medications such as nonsteroidal anti-inflammatory drugs, azathioprine, and trimethoprim-sulfamethoxasole, well viruses malignancy. Recurrent aseptic in SLE rare, remains a diagnostic challenge. Methods: We report unique patient recurrent (10 episodes), benign (self-limited) lymphocytic meningitis, which suggests diagnosis...
We reported a unique case with the coexistence of classic and cutaneous polyarteritis nodosa (PAN), microscopic polyangiitis (MPA) in hepatitis virus-associated vasculitis. A 77-year-old Asian man presented extremity weakness weight loss found to have bilateral foot drop rash on his hands legs. Labs reveal positive for B core antibody perinuclear-antineutrophil cytoplasmic (p-ANCA), decreased C3 C4 levels. Skin biopsy shows medium vessel vasculitis suggesting PAN. Interestingly, renal showed...
Immune checkpoint inhibitors (ICIs) are monoclonal antibodies that target T lymphocytes and stimulate the immune system. However, use of ICIs is associated with immune-related adverse events (irAEs). Pericardial disease a cardiovascular irAEs can present as cardiac tamponade. The precise mechanisms underlying pericardial complications not fully understood. Late-onset hemorrhagic effusion quite rare; mechanism predisposing factors yet to be determined. This case report describes patient...
A 30-year-old woman presented with angina pectoris. Coronary angiography revealed severe stenosis in the left main and right coronary arteries that did not improve intracoronary nitroglycerin. computed tomography positron emission ostia inflammation aortic root fat stranding. She was diagnosed vasculitis valvulitis received immunotherapy bypass. (Level of Difficulty: Advanced.)
Sarcoidosis is a systemic inflammatory disease that affects diverse organs such as the lungs, skin, eyes, and brain. Osseous involvement in sarcoidosis usually bones of appendages with direct infiltration non-caseating granulomas without bony infarcts. Symptoms sarcoid bone lesions respond well to corticosteroid therapy. In contrast, corticosteroids act risk factor for development osteonecrosis resulting pain disability. Osteonecrosis involves three or more different anatomic sites, defined...
Systemic lupus erythematosus (SLE) is a complex autoimmune disease characterised by multi-system involvement and diverse clinical manifestations. Among the systems affected, gastrointestinal hepatobiliary are notable taragets of response. Although hepatic syndromes commonly reported, gallbladder dysfunction rare not included in diagnostic criteria for disease. Biliary complications SLE can present as spectrum conditions, ranging from acalculous cholecystitis Salmonella infection to more...
Anti-synthetase syndrome (ASS) is characterized by myositis that associated with progressive interstitial lung disease (ILD). The prognosis of the affected type and degree pulmonary involvement. We report a rare case ASS positive Anti-EJ antibody presenting combination recurrent deep vein thrombosis/pulmonary embolism (DVT/PE) ILD. This demonstrates delayed diagnosis association thromboembolic ASS. Physicians should have high index suspicion for ASS, as early management alters morbidity...