A5031267739- Sarcoidosis and Beryllium Toxicity Research
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Neonatal Respiratory Health Research
- Intracerebral and Subarachnoid Hemorrhage Research
- Acute Ischemic Stroke Management
- Respiratory Support and Mechanisms
- Venous Thromboembolism Diagnosis and Management
- S100 Proteins and Annexins
- Ion Transport and Channel Regulation
- Atrial Fibrillation Management and Outcomes
- Antiplatelet Therapy and Cardiovascular Diseases
- Bacillus and Francisella bacterial research
- Cardiac Imaging and Diagnostics
- Cardiac Structural Anomalies and Repair
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Pneumocystis jirovecii pneumonia detection and treatment
- Neuroscience of respiration and sleep
- Cancer, Hypoxia, and Metabolism
- Ion channel regulation and function
- MicroRNA in disease regulation
- Pleural and Pulmonary Diseases
- Infectious Diseases and Tuberculosis
- Respiratory viral infections research
- Tuberculosis Research and Epidemiology
- Pneumonia and Respiratory Infections
University of Minnesota System
2015-2024
University of Minnesota
2014-2024
University of Minnesota Medical Center
2007-2024
Campbell Collaboration
2021
The Ocean Cleanup
2021
North Middlesex Hospital
2018
University College London Hospitals NHS Foundation Trust
2018
University College London
2018
Pulmonary and Allergy Associates
2014
Immunovaccine (Canada)
2009-2013
The severity of coronavirus 2019 infection (COVID-19) is determined by the presence pneumonia, severe acute respiratory distress syndrome (SARS-CoV-2), myocarditis, microvascular thrombosis and/or cytokine storms, all which involve underlying inflammation. A principal defence against uncontrolled inflammation, and viral in general, provided T regulatory lymphocytes (Tregs). Treg levels have been reported to be low many COVID-19 patients can increased vitamin D supplementation. Low associated...
Cerebral microbleeds are a potential neuroimaging biomarker of cerebral small vessel diseases that prone to intracranial bleeding. We aimed determine whether presence can identify patients at high risk symptomatic haemorrhage when anticoagulated for atrial fibrillation after recent ischaemic stroke or transient attack.
Background: Implantable cardioverter-defibrillators are used to prevent sudden cardiac death in patients with sarcoidosis. The most recent recommendations for implantable cardioverter-defibrillator implantation these the 2017 American Heart Association/American College of Cardiology/Heart Rhythm Society Guideline Management Patients With Ventricular Arrhythmias and Prevention Sudden Cardiac Death. These recommendations, based on observational studies or expert opinion, have not been...
<h3>Importance</h3> Alteration in lung microbes is associated with disease progression idiopathic pulmonary fibrosis. <h3>Objective</h3> To assess the effect of antimicrobial therapy on clinical outcomes. <h3>Design, Setting, and Participants</h3> Pragmatic, randomized, unblinded trial conducted across 35 US sites. A total 513 patients older than 40 years were randomized from August 2017 to June 2019 (final follow-up was January 2020). <h3>Interventions</h3> Patients a 1:1 allocation ratio...
In patients with sarcoidosis suspected cardiac involvement, late gadolinium enhancement (LGE) on cardiovascular magnetic resonance imaging (CMR) identifies those an increased risk of adverse outcomes. However, these outcomes are experienced by only a minority LGE, and identifying this subgroup may improve treatment in patients.To assess whether CMR phenotypes based left ventricular ejection fraction (LVEF) LGE (CS) associated during follow-up.This cohort study included consecutive...
In critical care, the monitoring is essential to daily care of ICU patients, as optimization patient's hemodynamic, ventilation, temperature, nutrition, and metabolism key improve patients' survival. Indeed, decisive endpoint supply oxygen tissues according their metabolic needs in order fuel mitochondrial respiration and, therefore, life. this sense, both oxygenation perfusion must be monitored implementation any resuscitation strategy. The emerging concept has been enhancement...
Abstract Background Sarcoidosis is a systemic granulomatous disease of unknown etiology. Clinical cohort studies different populations are important to understand the high variability in clinical presentation and course sarcoidosis. The aim study evaluate characteristics, including organ involvement, pulmonary function tests, laboratory parameters, sarcoidosis at University Minnesota. We compare system involvement this with other available cohorts. Methods conducted retrospective data...
A definitive dietary preparation recommendation is not possible based on literature the achievement of myocardial suppression for diagnosis cardiac sarcoidosis (CS) with <sup>18</sup>F-FDG PET/CT. Our goal to compare 3 different preparations in best and CS diagnosis. <b>Methods:</b> We retrospectively reviewed compared used at our institution. Three diets were applied from March 2014 December 2019: a 24-h ketogenic diet overnight fasting (<i>n</i> = 94); 18-h 44); 72-h daytime 3-d 98). The...
Thyroid hormone (T3) increases Na-K-ATPase activity in rat adult alveolar type II cells via a PI3K-dependent pathway. In these cells, dopamine and beta-adrenergic agonists can stimulate through either PI3K or MAPK pathways. We assessed the role of pathway stimulation by T3. II-like cell line MP48, T3 enhanced MAPK/ERK1/2 dose-dependent manner. Increased ERK1/2 phosphorylation was observed within 5 min, peaked at 20 then decreased. Two MEK1/2 inhibitors, U0126 PD-98059, each abolished...
Acute Respiratory Distress Syndrome (ARDS) continues to have a high mortality. Currently, there are no biomarkers that provide reliable prognostic information guide clinical management or stratify risk among trial participants. The objective of this study was probe the bronchoalveolar lavage fluid (BALF) proteome identify proteins differentiate survivors from non-survivors ARDS. Patients were divided into early-phase (1 7 days) and late-phase (8 35 groups based on time after initiation...
Abstract Pulmonary involvement occurs in up to 95% of sarcoidosis cases. In this pilot study, we examine lung compartment-specific protein expression identify pathways linked development and progression pulmonary sarcoidosis. We characterized bronchoalveolar lavage (BAL) cells fluid (BALF) proteins recently diagnosed identified 4,306 BAL cells, which 272 were differentially expressed compared controls. These map novel such as integrin-linked kinase IL-8 signaling previously implicated...
Rationale: Edema fluid resorption is critical for gas exchange and requires active epithelial ion transport by Na,K-ATPase other proteins.Objectives: In this study, we sought to determine if alveolar clearance (AFC) stimulated 3,3′,5 triiodo-l-thyronine (T3).Methods: AFC was measured in situ ventilated lungs ex vivo isolated instilling isosmolar 5% bovine serum albumin solution with fluorescein-labeled tracer measuring the change fluorescein isothiocyanate–albumin concentration over...
Background: There are few data on sex differences in suspected cardiac sarcoidosis. Methods: Consecutive patients with histologically proven sarcoidosis and involvement were studied. We investigated presenting features, involvement, the long-term incidence of a primary composite end point all-cause death or significant ventricular arrhythmia secondary points arrhythmia. Results: Among 324 patients, 163 (50.3%) female 161 (49.7%) male patients. Female had greater prevalence chest pain (37.4%...
Acute respiratory distress syndrome (ARDS) is associated with high mortality. We sought to identify biological pathways in ARDS that differentiate survivors from non-survivors. studied bronchoalveolar lavage fluid (BALF) 36 patients (20 survivors, 16 non-survivors). Each sample, obtained within seven days of onset, was depleted abundance proteins and labeled for iTRAQ LC-MS/MS separately. Protein identification relative quantification performed employing a target-decoy strategy. A variance...
Central venous access using peripherally inserted central catheters is frequently used for patients receiving intravenous medications in the hospital or outpatients. Although there are several benefits of catheters, such as ease insertion, low procedure-related risk and higher patient satisfaction, complications associated with catheter use. Despite some studies evaluating line-related complications, factors catheter-related deep thrombosis critically ill medical-surgical poorly described....
CD64 (or FcγRIA) is the sole functional high affinity IgG Fc receptor coded by FCGR1A gene in humans. The genetics has not been comprehensively investigated and effects of human variants on immune functions remain unknown. In current study, we identified three novel including single nucleotide variant (SNV) rs1848781 (c.-131) proximal promoter region, rs587598788 indel within intron 5, non-synonymous SNV rs1050204 (c.970G&gt;A or FcγRIA-p.D324N) coding region. Genotype-phenotype analyses...
Sarcoidosis is a multisystem granulomatous inflammatory disease of unknown etiology. There evidence that Tumor Necrosis Factor alpha (TNF-α) antagonists are useful in the treatment advanced or refractory disease. However, sarcoidosis-like reaction has been reported with TNF-α blockade other conditions. Here we report case sarcoid-like patient psoriatic arthritis shortly after initiation adalimumab therapy. Stopping and systemic anti-inflammatory therapy corticosteroids resulted resolution...
In rodent model systems, the sequential changes in lung morphology resulting from hyperoxic injury are well characterized and similar to human acute respiratory distress syndrome. injured lung, alveolar type two (AT2) epithelial cells play a critical role restoring normal structure. Thus characterizing AT2 will provide insights into mechanisms underpinning recovery injury. We applied an unbiased systems-level proteomics approach elucidate molecular contributing repair rat model. were...
Pulmonary complications due to infection and idiopathic pneumonia syndrome (IPS), a noninfectious lung injury in hematopoietic stem cell transplant (HSCT) recipients, are frequent causes of transplantation-related mortality morbidity. Our objective was characterize the global bronchoalveolar lavage fluid (BALF) protein expression IPS identify proteins pathways that differentiate from infectious after HSCT. We studied 30 BALF samples patients who developed within 180 days HSCT or cellular...