A5029502671- Transplantation: Methods and Outcomes
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Renal Transplantation Outcomes and Treatments
- Pulmonary Hypertension Research and Treatments
- Polyomavirus and related diseases
- Organ Transplantation Techniques and Outcomes
- Pneumocystis jirovecii pneumonia detection and treatment
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Sarcoidosis and Beryllium Toxicity Research
- Medical Imaging and Pathology Studies
- Respiratory Support and Mechanisms
- Systemic Sclerosis and Related Diseases
- Mechanical Circulatory Support Devices
- Intensive Care Unit Cognitive Disorders
- Asthma and respiratory diseases
- Organ and Tissue Transplantation Research
- Long-Term Effects of COVID-19
- SARS-CoV-2 and COVID-19 Research
- COVID-19 Clinical Research Studies
- Cardiac Structural Anomalies and Repair
- Trauma Management and Diagnosis
- Heparin-Induced Thrombocytopenia and Thrombosis
- Cystic Fibrosis Research Advances
- Pleural and Pulmonary Diseases
- Occupational and environmental lung diseases
Inova Fairfax Hospital
2018-2025
Inova Health System
2021-2024
Digital Research Alliance of Canada
2024
The Ocean Cleanup
2021
Inova Design Solutions (United Kingdom)
2020
Duke University
2014-2017
University of Kentucky
2011-2013
Purpose The outcomes of patients requiring invasive mechanical ventilation for COVID-19 remain poorly defined. We sought to determine clinical characteristics and with managed in an appropriately resourced US health care system. Methods Outcomes infected treated within the Inova Health System between March 5, 2020 April 26, were evaluated through electronic medical record review. Results 1023 positive admitted during study period. Of these, 164 (16.0%) ventilation. All followed definitive...
<h3>Importance</h3> Alteration in lung microbes is associated with disease progression idiopathic pulmonary fibrosis. <h3>Objective</h3> To assess the effect of antimicrobial therapy on clinical outcomes. <h3>Design, Setting, and Participants</h3> Pragmatic, randomized, unblinded trial conducted across 35 US sites. A total 513 patients older than 40 years were randomized from August 2017 to June 2019 (final follow-up was January 2020). <h3>Interventions</h3> Patients a 1:1 allocation ratio...
Rationale: The association of acute cellular rejection (ACR) with chronic lung allograft dysfunction (CLAD) in transplant recipients has primarily been described before consensus recommendations incorporating restrictive phenotypes. Furthermore, the degree molecular injury during ACR CLAD or death remains undefined. Objectives: To investigate risk and to further if this depends on injury. Methods: This multicenter, prospective cohort study included 188 recipients. Subjects underwent serial...
Abstract Background Coronavirus disease 2019 (COVID-19) requiring hospitalization is characterized by robust antibody production, dysregulated immune response, and immunothrombosis. Fostamatinib a novel spleen tyrosine kinase inhibitor that we hypothesize will ameliorate Fc activation attenuate harmful effects of the anti-COVID-19 response. Methods We conducted double-blind, randomized, placebo-controlled trial in hospitalized adults oxygen with COVID-19 where patients receiving standard...
Abstract Background Cytomegalovirus (CMV) infection is common in thoracic organ transplant recipients. Valganciclovir and ganciclovir are used for both prophylaxis treatment of this infection, but intolerance failure common. Letermovir has been demonstrated to reduce the risk CMV when allogeneic hematopoietic cell transplantation. However, there no data on its efficacy Methods We examined use letermovir either (primary secondary) or heart lung recipients at our institution from February 1,...
Respiratory viral infection (RVI) in lung transplant recipients (LTRs) is a risk for chronic allograft dysfunction (CLAD). We hypothesize that donor-derived cell-free DNA (%ddcfDNA), at the time of RVI predicts CLAD progression. followed 39 LTRs with enrolled Genomic Research Alliance Transplantation 1 year. Plasma %ddcfDNA was measured by shotgun sequencing, high as ≥1% within 7 days RVI. examined %ddcfDNA, spirometry, and composite (progression/failure) stage progression, re-transplant,...
Pulmonary hypertension (PH) commonly complicates idiopathic pulmonary fibrosis (IPF). However, the rate of change in hemodynamics IPF remains poorly defined. To examine among patients with IPF. The mean artery pressure (mPAP) and vascular resistance (PVR) was examined listed for lung transplantation. 5th 7th World Symposium on Hypertension definitions precapillary PH were employed this analysis. There 496 that had at least two right heart catheterizations (RHCs) while median time between...
The Distance-Oxygen-Gender-Age-Physiology (DO-GAP) index has been shown to improve prognostication in idiopathic pulmonary fibrosis (IPF) compared the Gender-Age-Physiology (GAP) score. We sought externally validate DO-GAP GAP for baseline risk assessment patients with IPF. Additionally, we evaluated utility of serial change predicting survival.We performed an analysis IPF from Pulmonary Fibrosis Foundation-Patient Registry (PFF-PR). Discrimination and calibration two models were assessed...
Rationale: Little is known about hospitalization in other types of interstitial lung disease (ILD) besides idiopathic pulmonary fibrosis (IPF). Objectives: We sought to determine the frequency hospitalizations various ILD and elucidate association with outcomes. Methods: An analysis Pulmonary Fibrosis Foundation Patient Registry data was performed. Inpatient rates survival following were compared for ILD. Results: Hospitalization similar across (40.6% IPF participants, 42.8% connective...
Background. A prior single-center, retrospective cohort study identified baseline lung allograft dysfunction (BLAD) as a risk factor for death in bilateral transplant recipients. In this multicenter prospective study, we test the association of BLAD with recipients, identify clinical factors BLAD, and assess its injury on molecular level. Methods. This multicenter, included 173 recipients that underwent serial pulmonary function testing plasma collection donor-derived cell-free DNA at...
Rationale: Video-assisted thoracoscopic surgery (VATS) remains the gold standard for interstitial lung disease (ILD) characterization when histology is deemed necessary. There diminishing use of VATS owing to increased reliance on high-resolution computed tomographic patterns, as well concerns regarding potential morbidity and mortality procedure.Objectives: The goal this study was evaluate safety tolerability among a broad group patients with ILD referred tertiary care center.Methods: Data...
Background and aims: Chest high-resolution computed tomography (HRCT) is the central diagnostic tool in discerning idiopathic pulmonary fibrosis (IPF) from other interstitial lung disease (ILDs). In 2018, new guidelines were published nomenclature for HRCT interpretation was changed. We sought to evaluate how clinicians’ would change based on reading HRCTs under framework of old versus categorization. Materials methods: collated 50 random cases evaluated Inova Fairfax ILD clinic. Six experts...