A5011045997- Diabetes Management and Research
- Diabetes Treatment and Management
- Respiratory Support and Mechanisms
- Intensive Care Unit Cognitive Disorders
- COVID-19 Clinical Research Studies
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Metabolism, Diabetes, and Cancer
- Long-Term Effects of COVID-19
- Diabetes and associated disorders
- Clinical Laboratory Practices and Quality Control
- Respiratory and Cough-Related Research
- Intravenous Infusion Technology and Safety
- COVID-19 Impact on Reproduction
- Reproductive Health and Technologies
- Pharmacology and Obesity Treatment
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Phagocytosis and Immune Regulation
- Voice and Speech Disorders
- Assisted Reproductive Technology and Twin Pregnancy
- Heart Rate Variability and Autonomic Control
- Protein Interaction Studies and Fluorescence Analysis
- Protein purification and stability
- Blood Pressure and Hypertension Studies
- Advanced Biosensing Techniques and Applications
- Homelessness and Social Issues
Inova Fairfax Hospital
2020-2022
Guy's Hospital
1984-2001
Hahnemann University Hospital
1995
<h3>BACKGROUND:</h3> Optimal timing of mechanical ventilation in COVID-19 is uncertain. We sought to evaluate outcomes delayed intubation and examine the ROX index (ie, [<math xmlns="http://www.w3.org/1998/Math/MathML" id="i1" display="inline" overflow="scroll"><mrow><msub><mi mathvariant="normal">S</mi><mrow><msub><mrow><mtext mathvariant="bold">pO</mtext></mrow><mn>2</mn></msub></mrow></msub><msub><mrow><mtext mathvariant="bold">/F</mtext></mrow><mrow><msub><mrow><mtext...
Purpose The outcomes of patients requiring invasive mechanical ventilation for COVID-19 remain poorly defined. We sought to determine clinical characteristics and with managed in an appropriately resourced US health care system. Methods Outcomes infected treated within the Inova Health System between March 5, 2020 April 26, were evaluated through electronic medical record review. Results 1023 positive admitted during study period. Of these, 164 (16.0%) ventilation. All followed definitive...
Abstract Background Coronavirus disease 2019 (COVID-19) requiring hospitalization is characterized by robust antibody production, dysregulated immune response, and immunothrombosis. Fostamatinib a novel spleen tyrosine kinase inhibitor that we hypothesize will ameliorate Fc activation attenuate harmful effects of the anti-COVID-19 response. Methods We conducted double-blind, randomized, placebo-controlled trial in hospitalized adults oxygen with COVID-19 where patients receiving standard...
We assessed the quality of overnight glycemic control and frequency “dawn phenomenon” (nadir–0800 h increase) in 41 insulin-dependent diabetic patients treated by continuous subcutaneous insulin infusion (CSII). Mean plasma glucose levels were near-normal during 24 and, particular, constant throughout night. In a subset six free concentrations also CSII. The majority profiles (88%) showed nadir from 2.0 to 5.9 mmol/L (most frequently at 0600 h) had an 0800 value 6.9 (92%). A large proportion...
Methods for blood sample preparation and radioimmunoassay of free antibody‐bound serum or plasma insulin concentrations, using polyethylene glycol (PEG) solution to precipitate bound insulin, have been evaluated compared. Method A was rapid mixing whole with PEG, followed by separation centrifugation into Ficoll; method B PEG addition blood, alone; C conventional thawed serum, remove insulin. found acceptable performance reproducibility; levels were not significantly different from those...
Eleven insulin-dependent diabetic patients were treated in random order by 2-mo continuous subcutaneous insulin infusion (CSII) or conventional injection treatment (CIT)with crossover to the alternative regimen. Mean plasma glucose concentrations throughout day significantly lower during CSII than CIT, but percentage of values &lt;2.5 mmol/L, obtained from outpatient self-collected diurnal profiles, was similar for both treatments (CSII vs. CIT: 5.9 and 4.8%, respectively). Reported...
The prevalence and patterns of insulinaemia in five groups patients with Type 1 diabetes have been reinvestigated using a free insulin assay which minimizes vitro redistribution the antibody-bound components. In 18 diabetic managed by conventional injection treatment 19 treated continuous subcutaneous infusion (CSII), mean 24-h serum level exceeded non-diabetic reference range 78% (injections) 68% (CSII). Twenty-four-hour profiles showed that hyperinsulinaemia occurred basal state before...
Abstract Purpose The outcomes of patients requiring invasive mechanical ventilation for COVID-19 remain poorly defined. We sought to determine clinical characteristics and with managed in an appropriately resourced US health care system. Methods Outcomes infected treated within the Inova Health System between March 5, 2020 April 26, were evaluated through electronic medical record review. Results 1023 positive admitted during study period. Of these, 165 (16.1%) ventilation. At time data...
To compare the performance of DCA2000 microalbuminuria system for albumin and creatinine concentrations albumin:creatinine ratio (ACR) with laboratory measurements in hospital diabetes clinic to assess ease use applicability by standard personnel.Urine concentration ACR were measured 154 diabetic patient samples 77 normal subjects. Both assays are based on immunoturbidimetry. The utilizes reagent cartridges processed automatically.Control material within-run precision (coefficient variation...
The powerful vasodilator, prostaglandin E 1 (PGE ), was added to Actrapid insulin try accelerate the early phase of subcutaneous absorption through increasing injection site blood flow. alone (6U) and containing PGE (7.5times10 ‐6 M) were injected on different days into 13 fasting insulin‐dependent diabetics. With insulin/PGE mixture, increases in both free total plasma concentrations greater at all times up 120 minutes after than with alone, signficant differences first 40 minutes. area...
In 25 insulin‐dependent diabetics, 14 managed by conventional insulin injection treatment (CIT) and 11 treated continuous subcutaneous infusion (CSII), there was a highly significant correlation between urinary excretion rate (IER) per 1.73 m 2 mean serum free concentration ( r = 0.73, p <0.001), measured over 24 h period. Urinary IER daily levels were significantly higher in diabetics than non‐diabetics. CSII‐treated patients had lower plasma glucose CIT‐treated despite similar values of...
Rationale:The outbreak of COVID-19 in March 2020 led to the emergent search for treatment options. Passive immune therapy with convalescent plasma (CCP) was utilized as an investigational therapy. We designed open label study and received new drug (IND) number from Food Drug Administration on April 11, 2020. Methods:Patients severe were enrolled identical ABO CCP administered. collected recovered patients by our hospital blood donor services line FDA guidelines. Patients could receive up...