A5057493735- Parkinson's Disease Mechanisms and Treatments
- Neurological disorders and treatments
- Botulinum Toxin and Related Neurological Disorders
- Amyotrophic Lateral Sclerosis Research
- Genetic Neurodegenerative Diseases
- Restless Legs Syndrome Research
- Neurogenetic and Muscular Disorders Research
- Dysphagia Assessment and Management
- Genetics and Neurodevelopmental Disorders
- Neurological diseases and metabolism
- Nuclear Receptors and Signaling
- Parkinson's Disease and Spinal Disorders
- Axon Guidance and Neuronal Signaling
- Neurogenesis and neuroplasticity mechanisms
- Multiple Sclerosis Research Studies
- Ginkgo biloba and Cashew Applications
- RNA regulation and disease
- Pluripotent Stem Cells Research
- Autism Spectrum Disorder Research
- Neuroinflammation and Neurodegeneration Mechanisms
- Pharmacological Effects and Toxicity Studies
- Sleep and Wakefulness Research
- Autoimmune Neurological Disorders and Treatments
- Nerve injury and regeneration
- Health Literacy and Information Accessibility
Fukuoka University
2016-2025
Toho University Medical Center Sakura Hospital
2025
Toho University
2025
Mayo Clinic in Florida
2017-2018
University of Alabama at Birmingham
2017
Fukuoka University Hospital
2017
Jacksonville College
2017
WinnMed
2017
Kyoto University
2016-2017
Tottori University
2016
Objective The objective of this study was to report the identification antibodies against glutamate kainate receptor subunit 2 (GluK2‐abs) in patients with autoimmune encephalitis, and describe clinical‐immunological features antibody effects. Methods Two sera from 8 similar rat brain immunostaining were used precipitate antigen neuronal cultures. A cell‐based assay (CBA) GluK2‐expressing HEK293 cells assess 596 different neurological disorders, 23 healthy controls. GluK2‐ab effects...
Objective Melatonin is effective for treating patients with rapid eye movement sleep behavior disorder (RBD). Ramelteon, a novel hypnotic, acts as melatonin receptor agonist. In the current study, we investigated effects of ramelteon on disorders, including RBD, in Parkinson's disease (PD). Methods We evaluated 35 from multiple centers idiopathic PD accompanied by disturbances (age: 69.1±11.1 years; 17 men, 18 women; morbidity: 6.9±5.7 Hoehn & Yahr stage: 2.5±0.8; levodopa dose equivalent:...
Perry syndrome is a rare atypical parkinsonism with depression, apathy, weight loss, and central hypoventilation caused by mutations in dynactin p150glued (DCTN1). A distal hereditary motor neuropathy, HMN7B, also has DCTN1. TAR DNA-binding protein of 43 kDa (TDP-43) inclusions as defining feature. Other TDP-43 proteinopathies include amyotrophic lateral sclerosis (ALS) frontotemporal lobar degeneration (FTLD) without neuron disease (FTLD-MND). forms aggregates neuronal cytoplasmic (NCIs),...
To establish international diagnostic criteria for Perry syndrome, a disorder characterised by clinical signs of parkinsonism, depression/apathy, weight loss, respiratory symptoms, mutations in the DCTN1 gene and TAR DNA-binding protein 43 (TDP-43) pathology.Data from published literature newly identified patients were gathered analysed during after International Symposium on syndrome Tokyo to identify syndrome.Eighty-seven with carrying 20 families included this study, common identified,...
Abstract The nervous system processes a vast amount of information, performing computations that underlie perception, cognition, and behavior. During development, neuronal guidance genes, which encode extracellular cues, their receptors, downstream signal transducers, organize neural wiring to generate the complex architecture system. It is now evident many these neuroguidance cues receptors are active during development also expressed in adult This suggests pathways critical not only for...
ABSTRACT Background Depression, parkinsonism, and hypoventilation (Perry syndrome) or familial motor neuron disease have been linked to mutations in dynactin P150 Glued ( DCTN1 ). Methods We employed genealogic, clinical, neurologic, MRI investigations, as well analysis of genes implicated parkinsonism. Cellular transfection, immunocytochemistry, immunoprecipitation wild‐type (WT) mutant were also performed. Results A novel heterozygous mutation, c.156T>G, encoding p.Phe52Leu, segregates...
A common pathological hallmark of several neurodegenerative diseases, including amyotrophic lateral sclerosis, is cytoplasmic mislocalization and aggregation nuclear RNA-binding protein TDP-43. Perry disease, which displays inherited atypical parkinsonism, a type TDP-43 proteinopathy. The causative gene DCTN1 encodes the largest subunit dynactin complex. Dynactin associates with microtubule-based motor dynein required for dynein-mediated long-distance retrograde transport. disease-linked...
Gastrointestinal symptoms are one of the most common non-motor features Parkinson's disease (PD). Recently, a report from Taiwan revealed that irritable bowel syndrome (IBS) may be associated with an increased risk developing PD; however, prevalence IBS in PD patients has not been fully evaluated. Rome III criteria widely assessed questionnaire to determine functional gastrointestinal disorders.We constipation and our cohort using criteria.Between October 2014 April 2015, 118 were treated at...
IntroductionParkinson's disease (PD) is characterized by a range of classic motor symptoms and heterogeneous nonmotor that affect patients' quality life (QoL). Studies have individually reported the effect either or on QoL; however, thorough assessment greatest influence QoL limited. This JAQPAD study examined both patient demographics in large population patients with PD Japan.MethodsAll members Japan Parkinson's Disease Association were invited to participate study. Questionnaires...
With technological applications, especially in genetic testing, new diseases have been discovered and disease concepts proposed recent years; however, the pathogenesis treatment of these rare are not as well established those common diseases. To demonstrate importance research, this paper we focus on our research topic, Perry (Perry syndrome). is a autosomal dominant neurodegenerative disorder clinically characterized by parkinsonism, depression/apathy, weight loss, respiratory symptoms...
Parkinson's disease (PD) is a progressive neurodegenerative disease. As the severity of worsens, patients have lower tolerance for treatments and occasionally need to be hospitalized. This study focuses on characteristics with PD who were emergently admitted our hospital evaluates their prognosis during hospitalization.Hospital-based emergency admission was conducted in consecutive series between April 2009 March 2015.A total 164 admissions involving 136 available medical records identified....
ABSTRACT A switch in the response of commissural axons to repellent Slit is crucial for ensuring that they cross ventral midline only once. However, underlying mechanisms remain be elucidated. We have found both endocytosis and recycling Robo1 receptor are modulating sensitivity vertebrate axons. its back cell surface maintained stability axonal during stimulation. identified Arf6 guanosine triphosphatase activators, cytohesins, as previously unknown components Slit-Robo1 signalling neurons....
Long-term levodopa treatment in patients with Parkinson's disease (PwPD) often causes motor fluctuations, which are known to affect their quality of life (QOL). These fluctuations may be accompanied by non-motor symptoms. There is no consensus on how QOL.This was a single-center, retrospective study and included 375 who visited the neurology outpatient department Fukuoka University Hospital between July 2015 June 2018. All were evaluated for age, sex, duration, body weight, symptoms Movement...
Perry disease is a hereditary neurodegenerative with autosomal dominant inheritance. It characterized by parkinsonism, psychiatric symptoms, unexpected weight loss, central hypoventilation, and transactive-response DNA-binding protein of 43kD (TDP-43) aggregation in the brain. In 2009, was found to be caused dynactin I gene (DCTN1), which encodes subunit p150 on chromosome 2p, patients disease. The complex motor that associated axonal transport. Presently, at least 8 mutations 22 families...
We herein report a 71-year-old woman presented with fever, arthralgia, general malaise and leg muscle stiffness following administration of the COVID-19 mRNA vaccine (Comirnaty, Pfizer-BioNTech). Laboratory findings showed an elevated C-reactive protein level erythrocyte sedimentation rate. In addition, Gallium-67 scintigraphy demonstrated increased uptake in multiple joints. Typing human leukocyte antigen (HLA) revealed presence DRB1*0404/*0803 allele. These met diagnostic criteria for...
The delayed-on phenomenon (DOP) related to levodopa treatment frequently disturbs quality of life in advanced-stage Parkinson's disease (PD) patients. objective this study was explore the impact swallowing dysfunction on development DOP.Swallowing function investigated by endoscopic evaluation 11 PD patients with DOP and 9 without during phase. Residual drug pharynx after taking tablet, capsule, powder forms also observed.Residual seen six cases (30.0%). Pooling saliva, delayed reflex,...
A 78-year-old man developed paresthesias in the extremities. He was referred to our hospital because of positive anti-human T-cell leukemia virus type 1 (HTLV-1) antibodies serum and presence abnormal lymphocytes. diagnosed as chronic-type adult leukemia/lymphoma. Neurological examination revealed sensory impairment distal parts extremities with loss deep tendon reflexes. Nerve conduction study showed motor demyelinating polyneuropathy, indicating a diagnosis HTLV-1-associated neuropathy....