A5016469770- Parkinson's Disease Mechanisms and Treatments
- Dementia and Cognitive Impairment Research
- Alzheimer's disease research and treatments
- Neurological Disease Mechanisms and Treatments
- Olfactory and Sensory Function Studies
- Neurological and metabolic disorders
- Ginkgo biloba and Cashew Applications
- Neurological diseases and metabolism
- Neurological disorders and treatments
- Neuroinflammation and Neurodegeneration Mechanisms
- Genetic Neurodegenerative Diseases
- Amyotrophic Lateral Sclerosis Research
- Sleep and Wakefulness Research
- Functional Brain Connectivity Studies
- Transcranial Magnetic Stimulation Studies
- Lysosomal Storage Disorders Research
- Epigenetics and DNA Methylation
- S100 Proteins and Annexins
- Advanced Glycation End Products research
- Cerebrovascular and genetic disorders
- Neurological Disorders and Treatments
- Folate and B Vitamins Research
- Metabolism and Genetic Disorders
- Sleep and related disorders
- Epilepsy research and treatment
Mayo Clinic in Florida
2016-2025
St. Marianna University School of Medicine
2020-2025
Juntendo University
2010-2022
Tokyo Metropolitan Geriatric Hospital
2012-2022
Jacksonville College
2017-2019
Mayo Clinic
2018
WinnMed
2017-2018
Niigata University
2018
Fukuoka University
2017
University of Alabama at Birmingham
2017
Background: Probiotics have been reported to ameliorate cognitive impairment. Objective: We investigated the effect of probiotic strain Bifidobacterium breve MCC1274 (A1) in enhancing cognition and preventing brain atrophy older patients with mild impairment (MCI). Methods: In this RCT, 130 aged from 65 88 years old suspected MCI received once daily either (B. MCC1274, 2×1010 CFU) or placebo for 24 weeks. Cognitive functions were assessed by ADAS-Jcog MMSE tests. Participants underwent MRI...
Non-motor symptoms are recognized to enable the early detection of Parkinson's disease (PD). It remains unknown when those appear in dementia with Lewy bodies (DLB).We investigated prevalence 15 non-motor PD at onset memory loss based on a standardized worksheet 34 patients DLB, 32 Alzheimer's (AD) and 30 normal controls.DLB exhibited significantly higher olfactory dysfunction, constipation, increased saliva signs rapid eye movement sleep behavior disorder than AD controls.Paying attention...
Abstract Background Cognitive impairment is one of the core features progressive supranuclear palsy. This study aimed to clarify profile cognitive and its underlying pathology in Methods We retrospectively reviewed medical records evaluate pattern severity 121 autopsy‐confirmed palsy patients. A subset 37 patients underwent neuropsychological evaluation as part their clinical workup. The burden palsy‐related tau (neurofibrillary tangles/pretangles, coiled bodies, tufted astrocytes, threads)...
Perry syndrome is a rare atypical parkinsonism with depression, apathy, weight loss, and central hypoventilation caused by mutations in dynactin p150glued (DCTN1). A distal hereditary motor neuropathy, HMN7B, also has DCTN1. TAR DNA-binding protein of 43 kDa (TDP-43) inclusions as defining feature. Other TDP-43 proteinopathies include amyotrophic lateral sclerosis (ALS) frontotemporal lobar degeneration (FTLD) without neuron disease (FTLD-MND). forms aggregates neuronal cytoplasmic (NCIs),...
There is emerging evidence implicating a role for the autophagy-lysosome pathway in pathogenesis of Lewy body disease. We investigated potential neuropathologic and biochemical alterations pathway-related proteins brains patients with dementia bodies (DLB), Alzheimer disease (AD), control subjects using antibodies against Ras-related protein Rab-7B (Rab7B), lysosomal-associated membrane 2 (LAMP2), microtubule-associated 1A/1B light chain 3 (LC3). In DLB, but not brains, there were large...
Abstract Studies assessing genetic associations with neuropathological features in Lewy body disease (LBD) have been limited to candidate gene investigations, and therefore information is lacking regarding the architecture of neuropathology LBD. In current study, we examined a large series neuropathologically-confirmed LBD cases (N=980 discovery series, N=503 replication series) performed genome-wide association studies (GWAS’s) 11 different outcome measures. The outcomes included Braak...
Background: Previous longitudinal studies have revealed that specific patterns on [18F]-fluoro-d-glucose (FDG) positron emission tomography (PET) scans in patients with amnesic mild cognitive impairment can predict Alzheimer's disease (AD). However, the significance of particular [18F]-FDG PET prodromal dementia Lewy bodies (DLB) remains unclear. Methods: Based prevailing evidence rapid eye movement (REM) sleep behavior disorder (RBD) often precedes onset DLB, nine non-demented reporting...
To describe clinical and pathologic characteristics of diffuse Lewy body disease (DLBD) manifesting as corticobasal syndrome (CBS).In 523 autopsy-confirmed cases DLBD, we identified 11 patients diagnosed with CBS. For comparison, studied 22 DLBD brains antemortem presentation dementia bodies (DLB). Given previous studies suggesting the importance pathology in peri-Rolandic cortices CBS, used digital to count quantify intracytoplasmic neuritic α-synuclein phospho-tau burden motor cortex.DLBD...
In order to conduct early therapeutic interventions for Alzheimer's disease (AD), convenient, diagnosis markers are required. We previously reported that changes in DNA methylation levels were associated with amnestic mild cognitive impairment (aMCI) and AD. As the results suggested COASY SPINT1 gene promoter regions, present study we examined these regions normal controls (NCs, n = 30), aMCI subjects (n 28) AD 30) using methylation-sensitive high resolution melting (MS-HRM) analysis. The...
From the standpoint of early interventions for dementia, a convenient method diagnosis using biomarkers is required Alzheimer's disease (AD) in stage as well amnesic mild cognitive impairment (aMCI). Focusing on differences DNA methylation due to AD and aMCI, present study, we first conducted genome-wide screening, measuring blood levels by Illumina Infinium HD Methylation Assay 3 small age-and gender-matched groups consisting 4 subjects each: normal controls (NC), aMCI AD. The analysis...
Objective The objective of this study was to describe clinical features, [ 18 F]‐fluorodeoxyglucose (FDG)‐positron emission tomography (PET) metabolism and digital pathology in patients with logopenic progressive aphasia (LPA) pathologic diagnosis diffuse Lewy body disease (DLBD) compare LPA other pathologies, as well classical features probable dementia bodies (pDLB). Methods This is a clinicopathologic case‐control 45 patients, including 20 prospectively recruited among whom 6 were...
Background Although metabolic reduction in the primary visual cortex on [ 18 F]‐fluoro‐ d ‐glucose (FDG) positron emission tomographic (PET) scans is hallmark of dementia with Lewy bodies (DLB) for differential diagnosis from Alzheimer's disease, clinical significance pattern patients without remains unknown. The purpose this study was to investigate profiles and its relevance DLB. Methods Of 145 individuals who underwent F‐FDG PET, 25 glucose hypometabolism were identified based...