A5047352256- Gastric Cancer Management and Outcomes
- Gut microbiota and health
- Esophageal Cancer Research and Treatment
- Esophageal and GI Pathology
- Gastrointestinal Tumor Research and Treatment
- Gallbladder and Bile Duct Disorders
- Pediatric Hepatobiliary Diseases and Treatments
- Metastasis and carcinoma case studies
- Pancreatic and Hepatic Oncology Research
- Neuroendocrine Tumor Research Advances
- Liver Disease and Transplantation
- Helicobacter pylori-related gastroenterology studies
- Diet and metabolism studies
- Genetic factors in colorectal cancer
- Pancreatitis Pathology and Treatment
- Liver Disease Diagnosis and Treatment
- Abdominal vascular conditions and treatments
- Intensive Care Unit Cognitive Disorders
- Alzheimer's disease research and treatments
- Tryptophan and brain disorders
- Gastrointestinal disorders and treatments
- Lung Cancer Research Studies
- Hepatitis C virus research
- Probiotics and Fermented Foods
- Peanut Plant Research Studies
Shizuoka General Hospital
2017-2025
Morinaga (Japan)
2020-2022
Nagoya City University
2022
National Institute of Infectious Diseases
2021
Niigata University
2021
Dokkyo Medical University
2011-2013
Shizuoka City Hospital
2013
The University of Tokyo
2013
Kyoto Prefectural University of Medicine
2008
Shizuoka Saiseikai General Hospital
2003
Probiotics use has been associated with modulation of inflammation and considered as a possible intervention for CNS diseases such mild cognitive impairment (MCI) dementia.We aimed to test the effect probiotic strain, Bifidobacterium breve A1 (MCC1274), restore cognition in physically healthy, suspected MCI population.In this randomized, double-blind, placebo-controlled trial, 80 healthy older adults suffering from were divided into two even groups receive once daily either (B. A1, 2×1010...
Background: Probiotics have been reported to ameliorate cognitive impairment. Objective: We investigated the effect of probiotic strain Bifidobacterium breve MCC1274 (A1) in enhancing cognition and preventing brain atrophy older patients with mild impairment (MCI). Methods: In this RCT, 130 aged from 65 88 years old suspected MCI received once daily either (B. MCC1274, 2×1010 CFU) or placebo for 24 weeks. Cognitive functions were assessed by ADAS-Jcog MMSE tests. Participants underwent MRI...
Probiotic supplementation reestablishes microbiome diversity and improves brain function in Alzheimer's disease (AD); their molecular mechanisms, however, have not yet been fully illustrated.We investigated the effects of orally supplemented Bifidobacterium breve MCC1274 on cognitive AD-like pathologies AppNL-G-F mice.Three-month-old mice were with B. for four months. The short-term memory was evaluated using a novel object recognition test. Amyloid plaques, amyloid-β (Aβ) levels, Aβ fibril,...
No specific biomarker for immune checkpoint inhibitor (ICI)-induced colitis has been established. Previously, we identified anti-integrin αvβ6 autoantibodies in >90% of patients with ulcerative (UC). Given that a subset ICI-induced is similar to UC, aimed clarify the relationship between such and colitis.
Abstract Background In the WHO 2010 classification, neuroendocrine tumors (NETs) are subdivided by their mitotic index or Ki67 into either G1 G2 NETs. Tumors with a of <2% classified as and those 3—20% G2. However, assessment greater than 2% less equal to 3% is still unclear. To resolve problem, we validated criteria gastrointestinal NETs classification. Methods The medical records 45 patients who were pathologically diagnosed having NET G1/G2 tract analyzed retrospectively. According...
The pathogenesis of non-ampullary duodenal epithelial tumors (NADETs) is not fully understood. NADETs that express gastric-type mucin phenotypes (G-NADETs) are noteworthy because their high malignancy. Gastric foveolar metaplasia, from which G-NADETs originate, protects the mucosa gastric acidity. As acid secretion affected by endoscopic mucosal atrophy (EGMA), we hypothesized EGMA would be associated with G-NADETs. To evaluate association between and occurrence This cross-sectional...
To perform endoscopic retrograde cholangiopancreatography (ERCP), cannulation of the common bile duct through major papilla is necessary. However, even experts fail to achieve selective biliary in 5% 20% cases [1]. When standard techniques fail, precut incision methods such as needle-knife sphincterotomy and transpancreatic (TPBS) can be employed. these also have failure rates 10% 40% [2]. Needle-knife allows for flexible lines but technically challenging, while TPBS easier limited by a...
Spontaneous regression (SR) of malignant tumors is defined as the partial or complete reduction a tumor without medical intervention. This unusual phenomenon has been reported in various types malignancies. We present rare case 73-year-old woman with untreated chronic hepatitis C who was diagnosed extensively diffused hepatocellular carcinoma (HCC) accompanied by thrombus left branch portal vein. Remarkably, extensive occurred under palliative care. highlights potential mechanisms...
Background Esophageal stricture causes severe distress to patients. However, there are no established treatments for refractory esophageal anastomotic endoscopic balloon dilation (EBD). Steroid injection added EBD and radial incision cutting (RIC) effective such strictures, but it is unclear which more effective. The objective of this study was investigate the safety efficacy RIC with steroid compared patients after esophagectomy. Methods This a multicenter, randomized phase II/III trial....
Background: We previously reported the effects of a probiotic strain, Bifidobacterium breve MCC1274, in improving cognitive function preclinical and clinical studies. Recently, we demonstrated that supplementation this strain led to decreased amyloid-β production, attenuated microglial activation, suppressed inflammation reaction brain APP knock-in (AppNL - G F) mice. Objective: In study, investigated plasma metabolites reveal mechanism action Alzheimer’s disease (AD)-like model. Methods:...
Abstract Background Accurate evaluation of tumor invasion depth is essential to determine the appropriate treatment strategy for patients with superficial esophageal cancer. The pretreatment diagnosis currently relies on magnifying endoscopic classification established by Japan Esophageal Society (JES). However, diagnostic accuracy tumors involving muscularis mucosa (MM) or those invading upper third submucosal layer (SM1), which correspond Type B2 vessels in JES classification, remains...
Abstract Background Endoscopic resection is widely accepted as a local treatment for rectal neuroendocrine tumors sized ≤ 10 mm. However, there no consensus on the best method endoscopic of tumors. As simplified procedure, submucosal with ligation device (ESMR-L) indicates histologically complete rate comparable to that dissection (ESD). We hypothesized ESMR-L than ESD would be preferred Hence, this trial aimed verify whether non-inferior in terms rate. Methods This prospective, open-label,...
Abstract Aims Small common bile duct stones are known to occasionally clear spontaneously. This study aimed prospectively assess the role of biliary stent placement in promoting spontaneous clearance small stones. Methods and Results We analyzed patients presenting with ≤5 mm diameter between June 2020 May 2022. The exclusion criteria included asymptomatic patients, pancreatitis, altered gastrointestinal anatomy, strictures (malignant or benign), a history EST. stents were inserted without...
Pancreatic cancer presents a critical health issue characterized by low survival rates. Identifying risk factors in specific populations, such as those with diabetes, is crucial for early detection and improved outcomes. This study aimed to identify pancreatic diabetic patients using longitudinal cohort from the Shizuoka Kokuho database, spanning April 2012 September 2021. Diabetic were identified monitored onset of cancer. Factors analyzed included age, sex, Elixhauser comorbidity index,...
The aim of our study was to evaluate the diagnosis desmoplastic reaction (DR) by immunostaining for α-smooth muscle actin (αSMA) and desmin, predicting depth submucosal invasion in biopsy specimens early colorectal carcinomas (CRCs). Thirty-eight cases non-pedunculated CRCs were included this study. Positive DR defined as αSMA-positive desmin-negative stroma CRC. measured endoscopically or surgically resected lesions subsequently divided into two groups: Group A (carcinoma situ/intramucosal...
We assessed whether there are differences in the diagnostic yield and safety of serial pancreatic juice aspiration cytologic examination (SPACE) among different indications. retrospectively analyzed 226 patients who underwent SPACE. They were classified into group A (patients with masses, including advanced adenocarcinoma, sclerosing pancreatitis, or autoimmune pancreatitis), B (suspicious carcinoma without obvious small carcinoma, situ, benign duct stenosis), C (intraductal papillary...
<b><i>Introduction:</i></b> Solid organ malignancies rarely metastasize to the duodenal papilla. We describe a case of primary lung cancer with papillary metastasis in patient who presented melena. To best our knowledge, this is only second report from cancer. <b><i>Case Presentation:</i></b> A 65-year-old woman complaints anorexia, weight loss, and black stool. Imaging studies led clinical diagnosis stage IVB cancer, anticoagulants were...