A5017446108- Gastric Cancer Management and Outcomes
- Colorectal Cancer Screening and Detection
- Gastrointestinal Tumor Research and Treatment
- Colorectal Cancer Surgical Treatments
- Metastasis and carcinoma case studies
- Neuroendocrine Tumor Research Advances
- Esophageal and GI Pathology
- Radiomics and Machine Learning in Medical Imaging
- Esophageal Cancer Research and Treatment
- Mechanisms of cancer metastasis
- Epigenetics and DNA Methylation
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Gastrointestinal disorders and treatments
- Lung Cancer Research Studies
- Genetic factors in colorectal cancer
- Pancreatic and Hepatic Oncology Research
- Liver Disease Diagnosis and Treatment
- Cancer Mechanisms and Therapy
- Cancer Diagnosis and Treatment
- RNA modifications and cancer
- Helicobacter pylori-related gastroenterology studies
- Hepatocellular Carcinoma Treatment and Prognosis
- FOXO transcription factor regulation
- DNA Repair Mechanisms
- Colorectal Cancer Treatments and Studies
National Cancer Center Hospital East
2019-2025
National Cancer Center
2023
Tokyo National Hospital
2019
Tohoku University
2010-2018
The multi-loop traction device (MLTD) facilitates optimal visualization of the submucosa throughout endoscopic submucosal dissection (ESD). This trial aimed to assess efficacy MLTD for colorectal ESD. We conducted a multicenter, open-label, randomized controlled involving patients with lesions ≥ 20 mm suspicious noninvasive carcinoma. Participants were randomly assigned in 1:1 ratio undergo ESD (MLTD-ESD group) or without any (control group). Endoscopists allowed convert treatments if became...
Objectives We aimed to evaluate the efficacy of texture and color enhancement imaging (TXI), which allows acquisition brighter images with enhanced surface structure in colorectal polyp detection compared white light imaging. Methods Patients who underwent colonoscopy repeated ascending colon observation using TXI between August 2020 January 2021 were identified three institutions. The outcomes included mean number adenomas detected per procedure (MAP), adenoma rate (ADR), colonic miss...
Abstract Background Endoscopic resection is widely accepted as a local treatment for rectal neuroendocrine tumors sized ≤ 10 mm. However, there no consensus on the best method endoscopic of tumors. As simplified procedure, submucosal with ligation device (ESMR-L) indicates histologically complete rate comparable to that dissection (ESD). We hypothesized ESMR-L than ESD would be preferred Hence, this trial aimed verify whether non-inferior in terms rate. Methods This prospective, open-label,...
There are several types of colorectal cancer (CRC) according to the detection methods and intervals, including interval CRC (iCRC) postcolonoscopy (PCCRC). We aimed examine their proportions characteristics.
Opportunistic endoscopic screening for gastric cancer was initiated in 2004 at our institute. We investigated chronological trends detection rates based on individual characteristics and atrophic gastritis prevalence.
The cost-effectiveness of endoscopic submucosal dissection (ESD) and piecemeal mucosal resection (pEMR) for colorectal laterally spreading tumors (LSTs) remains unclear. We examined the these procedures cases colon/rectal LST-non-granular-type ≥2 cm LST-granular-mixed-type ≥3 cm.We performed a simulation model analysis using parameters based on clinical data from National Cancer Center Hospital, Tokyo, previous literature. number recurrences surgeries required costs 5 years following ESD...
Colonoscopy is the gold standard for detecting and resecting adenomas or early stage cancers to reduce incidence mortality rates of colorectal cancer. In a recent observational study, texture color enhancement imaging (TXI) was reported improve polyp detection during colonoscopy. This randomized controlled trial involving six Japanese institutions aims confirm superiority TXI over white-light (WLI) in lesions During 1-year study period, 960 patients will be enrolled, with 480 WLI groups. The...
DNA methyltransferase (DNMT) inhibitors are epigenetic drugs used to treat myelodysplastic syndrome. They not only induce demethylation but also have significant cytostatic and cytotoxic effects; however, the relationships between these characteristics been established yet due lack of a method demethylation. Herein, we show that fusion protein comprised methyl-CpG-binding domain (MBD) catalytic Ten-eleven translocation 1 (TET1-CD) globally demethylates upregulates number methylated genes....
To examine whether reasonable detection rate of endoscopically diagnosed lesions as adenoma ("endoscopic" [ADR]) could be calculated with a database generated from colonoscopy reports and it used surrogate quality indicator "pathological" ADR.A lesion-by-lesion colonoscopies performed between 2010 2020 at eight Japanese endoscopy centers corresponding pathology were integrated. Differences in numbers detected polyps, "endoscopic" adenomas, what these differences attributed to examined. Polyp...
Abstract Background and Aim Serrated lesions (SLs) have attracted attention as precursors of colorectal cancer (CRC). However, their prevalence, risk factors, clinical significance not been satisfactorily elucidated. This study used high‐quality colonoscopy data to determine the prevalence SLs identify factors relationship with synchronous advanced neoplasia (ACN) in asymptomatic screened individuals. Methods included for 5218 individuals who underwent first‐time screening by highly...
Superficially serrated adenoma (SuSA) is a recently proposed subtype of colorectal lesions. It characterized by distinct clinicopathological and molecular features, including mixed adenomatous histology frequent genetic alterations involving KRAS RSPO. This study aimed to characterize the endoscopic features isolated traditional (TSA)-associated SuSAs.We retrospectively evaluated findings 25 SuSAs 21 TSA-associated that were histologically molecularly characterized.SuSAs appeared as sessile...
Pheochromocytomas and paragangliomas are neuroendocrine tumors which arise from adrenal medulla, sympathetic or parasympathetic nerves, respectively. Hereditary cases afflicted by both either pheochromocytomas have been reported: these called hereditary pheochromocytoma/paraganglioma syndromes (HPPS). Many of HPPS caused mutations one the succinate dehydrogenase (SDH) genes; mainly SDHB SDHD that encode subunits for mitochondrial respiratory chain complex II. In this study, we investigated...
Objectives Endoscopic hand suturing (EHS) is a novel technique for closing mucosal defect after endoscopic submucosal dissection (ESD). We investigated the technical feasibility of colorectal EHS using modified flexible through‐the‐scope needle holder. Methods This was prospective multicenter study conducted at two referral centers between June 2022 and April 2023. included neoplasms 20–50 mm in size located sigmoid colon or rectum. A holder, with an increased jaw width to facilitate...