A5030124308- Gastric Cancer Management and Outcomes
- Metastasis and carcinoma case studies
- Esophageal Cancer Research and Treatment
- Gastrointestinal Tumor Research and Treatment
- Helicobacter pylori-related gastroenterology studies
- Neuroendocrine Tumor Research Advances
- Cancer Immunotherapy and Biomarkers
- Hepatocellular Carcinoma Treatment and Prognosis
- Inflammatory Biomarkers in Disease Prognosis
- Liver Disease Diagnosis and Treatment
- Lung Cancer Research Studies
- Gastroesophageal reflux and treatments
- Colorectal Cancer Treatments and Studies
- Liver Disease and Transplantation
- Gastrointestinal disorders and treatments
- Microscopic Colitis
- Colorectal and Anal Carcinomas
- Renal and Vascular Pathologies
- Immune Cell Function and Interaction
- CAR-T cell therapy research
- Lung Cancer Diagnosis and Treatment
- Silicon and Solar Cell Technologies
- Soft tissue tumor case studies
- Multiple and Secondary Primary Cancers
- Digestive system and related health
Kanagawa Prefectural Hospital Organization
2011-2024
Kanagawa Cancer Center
2011-2024
Yokohama Minami Kyosai Hospital
2024
Edogawa Hospital
2019-2024
Yokohama Sakae Kyosai Hospital
2007-2009
Hitachi (Japan)
2003
Objective We evaluated the safety and efficacy of vonoprazan-based amoxicillin clarithromycin 7-day triple therapy (VAC) in comparison to proton pump inhibitor (PPI)-based (PAC) as a first-line treatment metronidazole (VAM) PPI-based (PAM) second-line for eradication Helicobacter pylori Japan.
Background Tumor-associated antigen (TAA)-specific CD8(+) T cells are essential for nivolumab therapy, and irradiation has been reported to have the potential generate activate TAA-specific cells. However, mechanistic insights of T-cell response during combinatorial immunotherapy using radiotherapy still largely unknown. Methods Twenty patients included in this study were registered CIRCUIT trial (ClinicalTrials.gov, NCT03453164 ). All had multiple distant metastases intolerance or...
Backgrounds and objectives Renal sinus fat (RSF) is an indicator of obesity-related complications. However, the measurement imaging process are complicated. For a simple RSF, we focused on kidney's shape change caused by RSF accumulation. Thus, this study aimed to investigate whether anteroposterior diameter renal (APDRS) computed tomography (CT) axial image useful for evaluating Materials methods The correlation between APDRS was investigated in 98 outpatients who underwent abdominal CT. In...
Background/Aim: We hypothesised that the prognostic nutrition index (PNI) is useful for evaluating host immunity and response to immune checkpoint inhibitors. investigated effect of PNI on nivolumab monotherapy efficacy in advanced or recurrent gastric cancer (GC) gastro-oesophageal junction (GOC) patients. Patients Methods: retrospectively examined 110 patients, divided them into a high-PNI group low-PNI group, compared treatment efficacy, adverse events (AEs), survival between groups....
Endoscopic resection, especially endoscopic submucosal dissection (ESD), is increasingly performed in elderly patients with early gastric cancer, and lesions beyond the expanded indications are also resected endoscopically some patients. It essential to assess whether ESD safe suitable for investigate what type of carry an increased risk ESD-related complications.To efficacy feasibility patients, define high-risk prognostic indicators.Among a total 1169 sessions Kanagawa Cancer Center...
Abstract Background Endoscopic resection is widely accepted as a local treatment for rectal neuroendocrine tumors sized ≤ 10 mm. However, there no consensus on the best method endoscopic of tumors. As simplified procedure, submucosal with ligation device (ESMR-L) indicates histologically complete rate comparable to that dissection (ESD). We hypothesized ESMR-L than ESD would be preferred Hence, this trial aimed verify whether non-inferior in terms rate. Methods This prospective, open-label,...
Trifluridine/tipiracil (FTD/TPI) is an anticancer-agent that administered as third-line or later chemotherapy for metastatic gastric/gastroesophageal junction cancer (mGC/GEJC). Although inflammatory and nutritional statuses have attracted attention prognostic factors patients with mGC/GEJC in this therapy, their usefulness has not been fully clarified. Thus, study investigated the clinical significance of index (PNI), neutrophil/lymphocyte ratio (NLR), NLR/serum albumin (Alb) FTD/TPI.This...
Objectives: Since the development of techniques for endoscopic submucosal dissection (ESD), indication range resection (ER) has been extended in early gastric cancer (EGC) treatment. For undifferentiated-type EGC, tumors with an intramucosal depth invasion, no ulceration and a diameter 20 mm or less were included expanded indications ER Japanese Gastric Cancer Treatment Guidelines 2010. Nonetheless, because difficulty detecting lesions that meet criteria ER, number endoscopically resected...
To evaluate the impact of development nivolumab monotherapy-induced immune-related adverse events (irAEs) and continuing with irAEs on survival patients gastric cancer (GC).Patients unresectable advanced GC recurrence after curative resection who received monotherapy were included in study. Survival was compared between did not develop irAEs, those continued discontinued treatment due to irAEs.Of 110 patients, 22 developed irAEs. Grade ≥3 IrAEs rash diarrhoea associated enteritis....
Abstract Background Although immune checkpoint inhibitors (ICI) targeting for PD-1 axis is a promising approach advanced gastric cancer (GC) patients, the response rate still limited. Induction of synergistic effect irradiation with ICI can be an attractive strategy. The aim this study was to assess combination anti-PD-1 therapy GC. Methods We conducted single-arm, phase I/II trial in GC patients treated nivolumab and oligo-fractionated (22.5 Gy/5 fractions/5 days) (NCT03453164). Eligible (...
There are few reports of conversion surgery (CS) after nivolumab monotherapy because it is considered as a third-line standard chemotherapy for unresectable or recurrent gastric cancer. Here, we report rare case stage IV cancer effectively treated with CS chemotherapy. A 73-year-old man was referred to our hospital loss appetite and abdominal discomfort. Stage liver metastasis diagnosed via upper gastrointestinal endoscopy CT. Twelve courses capecitabine, cisplatin, trastuzumab were...
Abstract For an esophageal submucosal mass suspicious of granular cell tumor (GCT) based on gross appearance and endoscopic ultrasound findings, a sufficient number biopsy specimens is required for definite diagnosis using immunohistochemical examination. When the specimen obtained by forceps insufficient, ultrasound-fine needle aspiration (EUS-FNA) believed to be useful alternative. However, it may difficult obtain adequate amount material EUS-FNA. Mucosal incision-assisted (MIAB) simple...
Duodenal neuroendocrine tumors (DNETs) smaller than 1 cm in diameter, without invasion to the muscularis propria, have a low risk of metastasis. Therefore, DNETs are frequently resected endoscopically. However, among various procedures, best fit for DNET terms feasibility, effectiveness, and simplicity is unclear.Patients with who underwent endoscopic submucosal resection using ligation device (ESMR-L) at Kanagawa Cancer Center between May 2003 December 2020 were studied retrospectively...
Abstract Heterotopic gastric gland (HGG)‐originating early cancer was endoscopically resected. We resected the HGG, widely marked perimeter outside submucosal tumor‐like area, injected from markings into submucosa, dissected muscular layer, and used fine‐tip hood. HGG removal ensuring negative horizontal vertical margins are critical.
Irinotecan and trifluridine/tipiracil (FTD/TPI) are fourth-line treatment options after third-line nivolumab for advanced gastric cancer (AGC). However, the efficacy safety of irinotecan FTD/TPI in setting remains unclear. This study aimed to evaluate nivolumab.We identified 137 AGC patients treated with as our institute between October 2017 July 2021. Of these, we recruited 19 who initiated 23 until September 2021.The median overall survival was 5.83 months 6.31 FTD/TPI. Median...
Trifluridine/tipiracil (FTD/TPI) is an oral anticancer agent used as a third- or later-line treatment for patients with metastatic gastric cancer/gastroesophageal junction cancer (mGC/GEJC). The C-reactive protein-to-serum albumin ratio (CAR) inflammation-based prognostic marker in cancer. This retrospective study evaluated CAR's clinical significance factor 64 mGC/GEJC administered FTD/TPI therapy. Patients were categorized into high- and low-CAR groups based on pre-treatment blood data....
The post-insertion clinical course of esophageal self-expandable metal stents (SEMS) in initially frail patients with carcinoma (EC) dysphagia remains unclear. This study aimed to assess improvement and evaluate prognosis advanced EC following SEMS insertion. We retrospectively reviewed who underwent insertion at our institution between January 2014 March 2023. Inclusion criteria comprised Eastern Cooperative Oncology Group Performance Status (ECOG PS) ≥ 3 or ECOG PS 2 for individuals aged...