A5000417011- Antifungal resistance and susceptibility
- Neuroendocrine Tumor Research Advances
- Thyroid Cancer Diagnosis and Treatment
- Fungal Infections and Studies
- Prostate Cancer Treatment and Research
- Sarcoma Diagnosis and Treatment
- Adrenal and Paraganglionic Tumors
- Pituitary Gland Disorders and Treatments
- Urologic and reproductive health conditions
- Gastric Cancer Management and Outcomes
- Prostate Cancer Diagnosis and Treatment
- Lung Cancer Research Studies
- Soft tissue tumor case studies
- Cardiac tumors and thrombi
- Plant Pathogens and Fungal Diseases
- Tumors and Oncological Cases
- Pancreatic and Hepatic Oncology Research
- Infectious Diseases and Mycology
- Peptidase Inhibition and Analysis
- Metastasis and carcinoma case studies
- Uterine Myomas and Treatments
- HER2/EGFR in Cancer Research
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Tracheal and airway disorders
- Neuroblastoma Research and Treatments
Kanagawa Prefectural Hospital Organization
2016-2025
Kanagawa Cancer Center
2016-2025
Toho University
2008-2016
University Medical Center
2015
University Hospital and Clinics
2015
Toho University Omori Medical Center
2013-2015
Teikyo University
2012
Saitama Medical University
2004
Fuchu Hospital
1976
Although gangliocytic paraganglioma (GP) has generally been regarded as a neuroendocrine tumor, its origin remains unclear. We therefore aimed to investigate the details of this disease by carefully analyzing and extracting common features presented in selected publications.We searched for English Japanese cases GP using PubMed IgakuChuoZasshi databases on August 2010. then extracted sampled raw data from publications performed appropriate statistical analyses. Additionally, we evaluated...
Bone metastasis occurs frequently in cancer patients. Conventional therapies have limited therapeutic outcomes, and thus, exploring the mechanisms of progression bone is important to develop new effective therapies. In microenvironment, adipocytes are major stromal cells that interact with during metastasis. However, comprehensive functions marrow not yet fully understood. To address this, we investigated role on cells, by focusing an invasive front reflects direct effects cancer....
Liposarcoma and lymphoma are very rare tumors, their combination is extremely rare. Moreover, there have been no reports of liposarcoma occurring in the same region. A 58-year-old man presented to Kanagawa Cancer Center with a mass his left thigh underwent needle biopsy. Histological analysis showed an increase number small lymphocytes plasma cells; immunohistochemical CD20-positive cells Lambda light-chain restriction; therefore, diagnosis B-cell malignancy cell differentiation was made....
Pulmonary tumor thrombotic microangiopathy (PTTM) has been known as a rare and serious cancer-related pulmonary complication. However, the pathogenesis pathophysiology of this debilitating condition still remains obscure no effective management was recommended. The present study aims to elucidate PTTM.Autopsy records were searched extract cases embolism induced by metastasis gastric carcinoma in Toho University Omori Medical Center from 2000 2006. And then, tissue sections extracted prepared...
Abstract Background Although cardiac fibroma has been regarded as benign tumor, it presents various symptoms and may lead to death. Unfortunately, only a few studies have reported the epidemiology, embryology, histopathology of factors predicting poorer outcome are still obscured. Methods In July 2011 we searched for English Japanese cases using PubMed IgakuChuoZasshi databases. We then extracted sampled raw data from selected publications in accordance with Preferred Reporting Items...
Gangliocytic paraganglioma (GP) is an extremely rare benign tumor that commonly arises from the second part of duodenum. Since GP exhibit neither prominent mitotic activity nor Ki-67 immunoreactivity, this often misdiagnosed as neuroendocrine (NET) G1 (carcinoid tumor). However, patients with may have a better prognosis than NET G1. This fact emphasizes importance differentiating G1, but few studies reported epidemiology and histopathology because its rarity. To differentiate ease, we...
Cryptococcus neoformans causes life-threatening diseases mainly in immunosuppressed hosts such as AIDS patients; C. gattii disseminated infections even healthy hosts. To identify the possible molecular mechanisms underlying this difference virulence, we investigated survival and histopathology of lung tissue wild-type CD4-depleted mice infected with H99 JP02 (the highly virulent strain isolated Japan); then compared dendritic cell (DC) cytokine release responses to different fractions from...
The prognosis of patients with progressive prostate cancers that are hormone refractory and/or have bone metastasis is poor. Multiple therapeutic targets to improve cancer patient survival been investigated, including orphan GPCRs. In our study, we identified G Protein-Coupled Receptor Class C Group 5 Member A (GPRC5A) as a candidate molecule using integrative gene expression analyses registered data sets for cell lines. Kaplan-Meier analysis TCGA revealed who high GPRC5A had significantly...
Cribriform pattern and intraductal carcinoma of the prostate (IDC-P) are widely accepted as poor prognostic factors in cancer. However, it remains unclear to what extent presence these morphological features biopsy specimens, diagnosed by hematoxylin-eosin-stained specimens only, affects clinicopathological impact. In this study, we summarized characteristics cribriform IDC-P 850 cases. The results showed a statistically significant increase incidence grade group (GG) increased (especially...
We describe a case of duodenal gangliocytic paraganglioma showing lymph node metastasis. A 61-year-old Japanese man underwent pylorus preserving pancreaticoduodenectomy to remove tumor at the papilla Vater. The section extending from mucosa submucosa duodenum was sharply demarcated, solid, and white-yellowish. Neither necrosis nor hemorrhage present. Histological examination confirmed immunohistochemical identification three components comprising epithelioid cells, spindle-shaped...
Cryptococcosis due to a highly virulent fungus, Cryptococcus gattii, emerged as an infectious disease on Vancouver Island in Canada and surrounding areas 1999, causing deaths among immunocompetent individuals. Previous studies indicated that C. gattii strain R265 isolated from the Canadian outbreak had immune avoidance or suppression capabilities. However, protective immunity against has not been identified. In this study, we used gain-of-function approach investigate infection using...
Thyroid carcinomas exhibit various genetic alterations, including the RET and NTRK fusion genes that are targets for molecular therapies. Thus, detecting is crucial devising effective treatment plans. This study characterized pathological findings associated with these to identify specimens suitable analysis. carcinoma cases positive were analyzed using Oncomine Dx Target Test. Clinicopathological data collected assessed. Among 74 patients tested, 8 had 1 NTRK3 gene. Specifically, of gene...
Abstract Formalin-fixed paraffin-embedded (FFPE) tissue samples are important for genomic analysis of thyroid carcinomas, particularly various molecularly targeted therapies. Therefore, this study developed and validated a technique preparing FFPE that preserves nucleic acid quality, which is fundamental precise analysis, more effectively than conventional methods. We analyzed surgically resected gland tumors, lymph node metastases, separately fixed tumor to optimize formalin fixation assess...
Background: Intraductal papillary‐mucinous neoplasm (IPMN) is an intraductal tumor in which the mucin‐producing epithelium shows proliferated papillary and a wide variety of pathological changes ranging from hyperplasia to adenocarcinoma. Therefore, it important determine whether IPMN benign or malignant. In present study patients with IPMN, protrusion was observed by peroral pancreatoscopy (PPS) using small‐diameter videoscope narrow‐band imaging (NBI). We carried out differential diagnosis...
Fetal adenocarcinoma is a rare variant of lung adenocarcinoma, which subcategorized into low-grade and high-grade forms. High-grade fetal confers worse prognosis than but the prognostic differences between conventional are unknown. We reviewed tissue sections 3719 cases surgically resected primary cancers found 53 with component. analyzed their clinicopathological immunohistochemical features, performed analysis adenocarcinomas fetal-type further component without Lung predominantly occurred...
Summary Clinical diagnosis of invasive fungal infections (IFIs) is sometimes difficult, and obtaining an accurate assessment trends concerning the prevalence IFIs a challenge. The aim this study was to determine in from autopsy survey. retrospective review records stored Toho University performed on all documented cases with infection 1955 2006. A total 411 were detected among 10 297 autopsies. candidiasis decreased 3.6% (1981–93) 2.0% (1994–2006), that aspergillosis increased throughout...
Although Cryptococcus gattii can cause life-threatening complications, putative virulence factors of C. remain controversial. Therefore, we conducted the present study to elucidate yeast and found that mortality rate mice infected with R265 was significantly higher than those 5815; however, no difference in rates between neoformans H99. In contrast, a significant histopathological findings lungs The former showed alveolar expansion due proliferation much lesser macrophage response, whereas...
A 75-year-old woman visited a nearby clinic with complaints of right clavicle discomfort, and she underwent diagnostic thoracoscopic lung biopsy, being diagnosed metastasis right-upper mediastinal mass. The superior mediastinum mass was extrapulmonary covered by the pleura, it not biopsied. Papillary thyroid carcinoma following biopsy metastasis. Only small tumor, maximum diameter 70 mm from neck to mediastinum, in gland invades internal jugular vein subclavian vein, forming tumor embolus...
Adipocytic tumors are the most common soft tissue tumors, with lipomas and atypical lipomatous tumor/well-differentiated liposarcomas (ALT/WDL), which comprise cases. Preoperative differential diagnosis of lipoma or ALT/WDL can provide important information for decisions regarding treatment. We evaluated cytological findings 20 cases ALT/WDL.Fluorescence in situ hybridization (FISH) was performed on formalin-fixed paraffin-embedded specimens (FFPE) to examine mouse double minute 2 homolog...
Inadequate specimen quality or quantity hinders comprehensive genomic profiling in identifying actionable mutations and guiding treatment strategies. We investigated the optimal conditions for pancreatic cancer selection profiling. retrospectively analyzed 213 cases ordered compared results from biopsy, liver biopsy of metastases, pancreatectomy, liquid, nonliver metastatic organ specimens. examined preanalytical conditions, including cellularity (tumor cell count/size). The successfully...
Fusarium has recently emerged as an opportunistic pathogen of humans, but the histological differentiation from Aspergillus and Scedosporium is particularly difficult because these fungi may induce similar clinical features exhibit filamentous development in host tissues. Thus, there a need to establish rapid reliable methods that are applicable pathological diagnoses. The aim this study was evaluate situ hybridization (ISH) using peptide nucleic acid (PNA) probes targeting 28S rRNA identify...