A5028296435- Thyroid Cancer Diagnosis and Treatment
- Thyroid and Parathyroid Surgery
- Neuroendocrine Tumor Research Advances
- Cancer Diagnosis and Treatment
- Head and Neck Anomalies
- Reconstructive Surgery and Microvascular Techniques
- BRCA gene mutations in cancer
- Cancer-related Molecular Pathways
- Lung Cancer Treatments and Mutations
- Epigenetics and DNA Methylation
- Cancer Cells and Metastasis
- Genetic Syndromes and Imprinting
- Medical Imaging and Pathology Studies
- Colorectal and Anal Carcinomas
- Cancer Immunotherapy and Biomarkers
- Parathyroid Disorders and Treatments
- Advanced Breast Cancer Therapies
- Cardiac tumors and thrombi
- HER2/EGFR in Cancer Research
- Pancreatic and Hepatic Oncology Research
- Mechanisms of cancer metastasis
- Cancer, Lipids, and Metabolism
- Congenital Diaphragmatic Hernia Studies
- Multiple and Secondary Primary Cancers
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
Kanagawa Cancer Center
2018-2025
Kanagawa Prefectural Hospital Organization
2018-2025
Yokohama City University
2009-2023
Yokohama City University Medical Center
2009-2023
Yokohama City University Hospital
2008-2020
Ito Hospital
2004
Abstract Formalin-fixed paraffin-embedded (FFPE) tissue samples are important for genomic analysis of thyroid carcinomas, particularly various molecularly targeted therapies. Therefore, this study developed and validated a technique preparing FFPE that preserves nucleic acid quality, which is fundamental precise analysis, more effectively than conventional methods. We analyzed surgically resected gland tumors, lymph node metastases, separately fixed tumor to optimize formalin fixation assess...
Anaplastic thyroid cancer (ATC) is associated with an extremely poor prognosis and resistant to the majority of chemotherapies. In 2015, lenvatinib was approved for treating ATC in Japan. The present study aimed evaluate overall survival (OS) patients treated lenvatinib. A total 23 a definitive histological diagnosis who were at Kanagawa Cancer Center (Yokohama, Kanagawa. Japan) enrolled. Surgical treatment possible 10 (including one debulking surgery), postoperatively started. remaining 13...
The tumor-node-metastasis (TNM) classification system to categorized anaplastic thyroid cancer (ATC) was revised.The revised evaluated using a large database of ATC patients.A total 757 patients were analyzed. proportion and median overall survival values (OS: months) for each T category T1 (n = 8, 1.1%, 12.5), T2 43, 5.7%, 10.9), T3a 117, 15.5%, 5.7), T3b 438, 57.9%, 3.9), T4 151, 19.9%, 5.0). OS the N0 N1 5.9 4.3, respectively (log-rank p < 0.01). Sixty-three (58.3%) migrated from stage IV...
Thyroid carcinomas exhibit various genetic alterations, including the RET and NTRK fusion genes that are targets for molecular therapies. Thus, detecting is crucial devising effective treatment plans. This study characterized pathological findings associated with these to identify specimens suitable analysis. carcinoma cases positive were analyzed using Oncomine Dx Target Test. Clinicopathological data collected assessed. Among 74 patients tested, 8 had 1 NTRK3 gene. Specifically, of gene...
The relationship between the genomic profile and prognosis of advanced thyroid carcinoma requiring drug therapy has not been reported.
Abstract Background Mixed medullary and follicular cell-derived thyroid carcinoma (MMFCC) is characterized by the coexistence of C cell–derived tumour cell populations within same lesion. Due to its rarity, etiology clinical course remain unclear, treatment for advanced or recurrent cases has not been established. Case presentation We report a case MMFCC treated with selpercatinib. The patient was 69-year-old male presenting tumors in right lobe upper mediastinum. Fine-needle aspiration...
Standard treatment for stage II/III gastric cancer is curative resection followed by adjuvant chemotherapy. However, the five-year survival remains unsatisfactory. Inhibin βA (INHBA) has been reported to be associated with cell proliferation and chemoresistance.We studied clinical significance of INHBA gene expression in 134 patients who received chemotherapy S-1. specimens tissue adjacent normal mucosa was measured quantitative real-time, reverse-transcription polymerase chain reaction...
Thyroid cancer is one of the most common endocrine malignancies. It primarily classified into four types : papillary thyroid cancer, follicular medullary and anaplastic (ATC). Among them, ATC particularly rare, has a very poor prognosis insensitive to conventional treatments. Consequently, development effective therapeutic strategies for urgently needed. Mutations in TP53 have been reported play role transformation cancer. frequently mutated gene across all human cancers. Although missense...
Abstract Some patients with differentiated thyroid cancer (DTC) may require an initial low dose (LD) of lenvatinib. However, few studies have investigated the efficacy LD We compared and tolerability lenvatinib at to those standard 24 mg in DTC. In this cross-sectional study, records DTC treated were retrospectively reviewed. Patients divided into 2 groups based on lenvatinib: a full-dose (FD) group that received mg/d less than mg/d. Categorical variables Fisher exact test continuous Student...
Thyroid dysfunction is occasionally reported after the administration of nivolumab. We report on incidence and risk factors for nivolumab-induced thyroid in patients with non-small lung cancer.A total 82 who received nivolumab between January 2016 December at Kanagawa Cancer Center were included. Prior to treatment, 72 had normal function.Among function prior was 19.5%. There no significant differences whom occurred regarding sex, age, dose, or administration. However, number doses...
Enhancer of zeste homolog 2 (EZH2) is a member the polycomb group genes, which are key factors in regulation cell proliferation and differentiation. EZH2 overexpressed many malignancies. We analyzed protein expression levels different histological subtypes thyroid cancer to examine its utility as prognostic factor.We examined by immunohistochemistry tissue samples from 67 cases poorly differentiated (PDTC) 48 anaplastic carcinoma (ATC), adjacent normal (DTC). differences among various types...
Anaplastic thyroid cancer (ATC) is an orphan disease with extremely poor prognosis. In particular, unresectable stage IVC ATC difficult to treat and associated a survival of only few months, even when treated irradiation and/or chemotherapy. 2015, lenvatinib was approved for the treatment in Japan. The aim present study evaluate efficacy ATC. A total 32 patients pathologically confirmed who were at Kanagawa Cancer Center between 2011 2018 included study, whom 16 (L group). remaining received...
The present study evaluated the efficacy and safety of TJ-54 (Yokukansan; a traditional Japanese medicine) for prevention and/or treatment postoperative delirium in randomized phase II trial patients receiving surgery gastrointestinal lung malignancies. Patients ≥70 years age who underwent or malignancy were eligible participation study. 186 randomly assigned at 1:1 ratio to receive control during their peri-operative care (between 7 days prior 4 following surgery, except operation day)....
In patients with distant metastasis, treatment for differentiated thyroid cancer (DTC) includes complete total thyroidectomy, followed by radioactive iodine (RAI) therapy metastatic lesions. Tyrosine kinase inhibitor (TKI) is the final option lesions, which incurable surgery/RAI therapy. The present study examined whether outcomes DTC in metastasis improved following TKI treatment. This included 147 (median age, 71; range, 33‑91 years) who underwent surgery our hospitals and were diagnosed...
Herein, we report two extremely rare cases of differentiated thyroid carcinoma (DTC) with extended tumor thrombus or mediastinum lymph node metastasis (LNM) involving the superior vena cava (SVC), causing SVC syndrome. Both these patients were successfully treated radical resection and reconstruction using autologous tissue instead an expanded polytetrafluoroethylene (ePTFE) graft. The left brachiocephalic vein was used to reconstruct in a papillary patient LNM pericardial patch follicular...
In metastatic breast cancer, the status of estrogen receptor (ER), progesterone (PR), and human epidermal growth factor 2 (HER2), as well Ki-67 index sometimes change between primary lesions. However, in expression levels enhancer zeste homolog (EZH2) lesions has not been determined cancer. Ninety-six cancer patients had biopsies or resections September 1990 February 2014 at Kanagawa Cancer Center. We evaluated ER, PR, HER2, Ki-67, EZH2 their corresponding using immunohistochemistry....
We analyzed the outcomes of genetic testing to study frequency mutations in advanced thyroid cancer Japan. Patients (n = 96) with unresectable or metastatic carcinoma were included for retrospective chart review. Results gene panel testing, which was performed between May 2020 and April 2023, analyzed. The median age patients 73.5 years (range, 17–88); 59 women, 39 men. Overall, 17 had anaplastic (ATC), 68 papillary (PTC), 7 follicular carcinoma, 6 poorly differentiated (PDTC). Of 81 (DTC)...
Anaplastic thyroid cancer (ATC) is a very rare disease with poor prognosis and no established effective drug therapy. The present study aimed to report the outcomes of lenvatinib single-agent therapy as an initial treatment in ATC, investigate its safety efficacy. This retrospective cohort included 56 patients unresectable primary whom 36 were treated 12 weekly paclitaxel, 8 who refused any received palliative care. average survival group was 5.8 months, which significantly longer than 2.0...
Summary Anaplastic transformation of a primary thyroid tumor whose process can be followed is rare. The objective this study to report case anaplastic locally advanced papillary carcinoma after treatment with lenvatinib. A 74-year-old woman consulted local physician because cough and bloody sputum. Thyroid cancer tracheal invasion was suspected on computed tomography (CT) imaging, she visited our hospital for treatment. We (ATC) core needle biopsy performed. Histologic sections the showed...
A 63-year-old man was diagnosed with multiple lung metastases from anaplastic thyroid cancer and received lenvatinib. Follow-up computed tomography on day 34 of lenvatinib treatment showed pneumothorax. The pneumothorax temporarily improved chest drainage. However, pleurodesis performed to treat a relapse the Pneumothorax during chemotherapy for malignant tumor is considered relatively rare complication. This case first documentation that may develop treatment. possible development should be...