A5085433417- Prostate Cancer Treatment and Research
- Prostate Cancer Diagnosis and Treatment
- Bladder and Urothelial Cancer Treatments
- Renal cell carcinoma treatment
- Cancer, Lipids, and Metabolism
- Urinary and Genital Oncology Studies
- Peptidase Inhibition and Analysis
- Urinary Bladder and Prostate Research
- Organ Donation and Transplantation
- Urologic and reproductive health conditions
- Estrogen and related hormone effects
- Urological Disorders and Treatments
- Muscle Physiology and Disorders
- Cancer, Hypoxia, and Metabolism
- Hormonal Regulation and Hypertension
- Adrenal and Paraganglionic Tumors
- Cancer Treatment and Pharmacology
- Renal and Vascular Pathologies
- Histone Deacetylase Inhibitors Research
- Epigenetics and DNA Methylation
- Genetics, Aging, and Longevity in Model Organisms
- Hormonal and reproductive studies
- Radiopharmaceutical Chemistry and Applications
- Cancer Immunotherapy and Biomarkers
- Angiogenesis and VEGF in Cancer
Ehime University
2016-2025
Ehime University Hospital
2009-2024
Ehime Medical Center
2011
Uwajima City Hospital
2003
Neuroendocrine prostate carcinoma (NEPC) accounts for less than 1% of neoplasms and has extremely poorer prognosis the typical androgen receptor pathway-positive adenocarcinoma (ARPC). However, very few cases in which de novo NEPC APRC are diagnosed simultaneously same tissue have been reported. We report herein a 78-year-old man metastatic coexisting with ARPC treated at Ehime University Hospital. Visium CytAssist Spatial Gene Expression analysis (10× genetics) was performed using...
Obesity correlates with an increased risk of developing prostate cancer (PCa) and leptin plays important role in PCa progression. Since is produced by adipocytes, the serum level higher obese than non-obese individuals. However, effects remain controversial unclear. The aim present study was to investigate effect on cell aggressiveness. Three human lines (LNCaP, DU145 PC-3) were treated recombinant for 28 days. Cell proliferation, migration, invasion estimated using WST assay, a...
Prostate-specific membrane antigen (PSMA) protein expression is induced during prostate cancer progression and metastasis. Recently, we reported that PSMA-positive vesicles released by cell lines enhanced vascular endothelial angiogenesis PSMA may be involved in tumor angiogenesis. Similarly, it known upregulated peritumoral vessels renal carcinoma (RCC). In this study, investigated the significance molecular function of RCC. immunohistochemical staining confirmed presence only perinephric...
The therapeutic efficacy of extended lymph node dissection (ePLND) for intermediate- and high-risk (IR/HR) prostate cancer remains controversial. This study evaluated whether PLND improved biochemical recurrence (BCR) rates in patients with undergoing robotic-assisted radical prostatectomy (RARP) using a propensity matching method cases from two facilities. included 1002 IR/HR disease who underwent RARP at facilities equivalent surgical techniques hospital size but different ePLND policies...
561 Background: The expression of prostate-specific membrane antigen (PSMA) protein increases as prostate cancer advances and metastasizes. Recently, 68Ga-labeled PSMA PET has been used in diagnosing cancer. Our previous studies demonstrated that PSMA-positive vesicles secreted by cells enhance the angiogenic activity vascular endothelial cells, suggesting a role for tumor angiogenesis. In this study, we focus on renal cell carcinoma, examining relationship between peritumoral blood vessels...
ABSTRACT Renal pelvic carcinoma in a horseshoe kidney is rare, and reports on robotic surgery for this condition are limited. We present case of 64‐year‐old male diagnosed with right renal kidney. The patient underwent robot‐assisted radical nephroureterectomy using the da Vinci Xi surgical system, preoperative anatomical visualization enhanced by 3D imaging software (SYNAPSE VINCENT). total operative time was 6 h 31 min, blood loss 185 mL. procedure completed without complications....
The prognosis of patients with progressive prostate cancers that are hormone refractory and/or have bone metastasis is poor. Multiple therapeutic targets to improve cancer patient survival been investigated, including orphan GPCRs. In our study, we identified G Protein-Coupled Receptor Class C Group 5 Member A (GPRC5A) as a candidate molecule using integrative gene expression analyses registered data sets for cell lines. Kaplan-Meier analysis TCGA revealed who high GPRC5A had significantly...
It has been suggested that aging of the immune system (immunosenescence) results in a decline acquired response, which is associated with an increase age-related tumorigenesis. T-cell senescence plays critical role immunosenescence and involved function, increases susceptibility to certain cancers. However, it shown CD8+ T cells senescent phenotype acquire natural killer (NK) cell-like function are tumor elimination. Therefore, immunity remains be elucidated. In this study, we investigated...
<b><i>Background:</i></b> To improve the prognosis of patients with urachal cancer and establish an effective chemotherapeutic regimen for distant metastases. <b><i>Methods:</i></b> We conducted a retrospective study to evaluate efficacy safety modified combination 5-fluorouracil, leucovorin oxaliplatin (mFOLFOX6) therapy in metastatic cancer. <b><i>Results:</i></b> Five were treated mFOLFOX6. Their median age was 65...
Intraductal carcinoma of the prostate (IDCP) has recently attracted increasing interest owing to its unfavorable prognoses. To effectively identify IDCP-specific gene expression profile, we took a novel approach characterizing typical IDCP case using spatial analysis. A formalin-fixed, paraffin-embedded sample was subjected Visium CytAssist Spatial Gene Expression within invasive cancer sites recognized as distinct cluster separate from other clusters. Highly expressed genes defining...
Promyelocytic leukemia zinc finger (PLZF) protein, a transcriptional repressor and negative regulator of the cell cycle, has been characterized as prostatic androgen-responsive gene. DU145 cells show androgen-independent growth lack PLZF gene expression.We analyzed PLZF-regulating genes by DNA microarray using infected with LacZ- or PLZF-carrying adenoviruses.DNA revealed that Pbx1 is prominent suppressed in PLZF-overexpressing cells. Androgen receptor (AR)-expressing recovered...
To examine the expression profile of histone deacetylase (HDAC)-1 and explore its potential role in development bladder cancer, using valproic acid (VPA), a HDAC inhibitor, which reduces tumour growth metastasis formation animal models.The study comprised clinical samples from patients with urinary mouse tissue specimens, two human cancer cell lines (HT-1376 5637). HDAC1 mRNA protein were examined real-time reverse transcription-polymerase chain reaction immunohistochemical methods. Female...
Cisplatin is currently the most effective anti-tumor agent available against bladder cancer. To clarify mechanism underlying cisplatin resistance in cancer, present study examined role of aldo-keto reductase family 1 member C2 (AKR1C2) protein on chemoresistance using a human cancer cell line. The function AKR1C2 was studied HT1376 line and cisplatin-resistant HT1376-CisR subline. expressed cells, but not parental cells. effect small interfering (si) RNAs an inhibitor targeting to determine...
Abstract Background Prostate‐specific membrane antigen (PSMA) is highly expressed in poorly differentiated, metastatic, and castration‐resistant prostate cancers. Recently, 68Ga‐PSMA positron emission tomography/computed tomography has been successfully developed as an effective diagnostic tool for cancer. However, the pathophysiological functions of PSMA tumors remain unclear. Methods We examined protein expression tumor endothelial cells human by immunohistochemistry. Prostate cancer...
Immune checkpoint inhibitor (ICI) therapy increases the risk of immune-related adverse events (irAEs). In particular, combination blockade (CCB) targeting inhibitory CTLA-4 and PD-1 receptors could lead to irAEs at a higher rate than ICI monotherapy. Management is important while using ICIs. However, there are no reliable biomarkers for predicting irAEs. The aim this study was elucidate early B cell changes after CCB in patients with renal carcinoma (RCC) verify whether cells can be...
Aquaporins (AQPs) function as selective pores allowing water, glycerol and other small solutes to pass through the cell membrane. The present study investigated expression localization of AQP3 in human prostate.Three prostate cancer lines (DU-145, LNCaP PC-3) one normal line (PNT1A) were used this study. Clinical materials from patients with also used. mRNA protein examined using reverse transcription-polymerase chain reaction immunohistochemical methods.Aquaporin 3 was expressed cancerous...
DNA methylation is an essential form of epigenetic regulation responsible for cellular identity. In muscle stem cells, termed satellite patterns are tightly regulated during differentiation. However, it unclear how these affect the function cells. We demonstrate that a key regulator, ubiquitin like with PHD and RING finger domains 1 (Uhrf1), activated in proliferating myogenic cells but not expressed quiescent or differentiated mice. Ablation Uhrf1 mouse impairs their proliferation...
Benign prostatic hyperplasia (BPH) is an age-related disease of unknown etiology characterized by enlargement and coinciding with distinctive alterations in tissue histomorphology. To identify the molecular mechanisms underlying development BPH, we conducted a DNA microarray study using previously described animal model which chronic α(1)-adrenergic stimulation repeated administration phenylephrine evokes histomorphological changes rat prostate that resemble human BPH. Bioinformatic tools...