A5076157758- Muscle Physiology and Disorders
- Frailty in Older Adults
- Nutrition and Health in Aging
- Cerebral Palsy and Movement Disorders
- Balance, Gait, and Falls Prevention
- Health disparities and outcomes
- Venous Thromboembolism Diagnosis and Management
- Diagnosis and Treatment of Venous Diseases
- Sports injuries and prevention
- Stroke Rehabilitation and Recovery
- Dysphagia Assessment and Management
- Virus-based gene therapy research
- Exercise and Physiological Responses
- Muscle activation and electromyography studies
- Child Nutrition and Feeding Issues
- Liver physiology and pathology
- Vascular Procedures and Complications
- Tendon Structure and Treatment
- Reproductive Health and Technologies
- Reproductive Biology and Fertility
- Anesthesia and Sedative Agents
- Liver Disease Diagnosis and Treatment
- Diet and metabolism studies
- Cardiac, Anesthesia and Surgical Outcomes
- Prostate Cancer Diagnosis and Treatment
Kitasato University
2016-2025
Kobe University
2025
Ehime University
2024-2025
Keio University
2024-2025
St. Marianna University School of Medicine
2000-2024
Tachikawa Hospital
2024
University Kebangsaan Malaysia Medical Centre
2023
Fukushima Medical University
2023
Teikyo University
2018-2021
Toho University
1991-2016
Human γδ T cells can recognize and kill non-small cell lung cancer (NSCLC) using the Vγ9Vδ2 T-cell receptor and/or NKG2D. We have established clinical grade large-scale ex vivo expansion of from peripheral blood mononuclear by culturing with zoledronate interleukin-2 (IL-2). A phase I study was conducted to evaluate safety potential antitumor effects re-infusing expanded in patients recurrent or advanced NSCLC. Patient's were stimulated (5 μM) IL-2 (1000 IU/mL) for 14 days. Harvested cells,...
Duchenne muscular dystrophy (DMD) is a lethal disorder of skeletal muscle caused by mutations in the dystrophin gene. Adeno-associated virus (AAV) vector-mediated gene therapy promising approach to disease. Although rod-truncated microdystrophin has been proven ameliorate dystrophic phenotypes, level expression required for effective an AAV vector not determined yet. Here, we constructed recombinant type 2 vector, AAV2-MCKDeltaCS1, expressing (DeltaCS1) under control muscle-specific MCK...
Abstract Background Prognosis of chronic thromboembolic pulmonary hypertension (CTEPH) has improved after the availability balloon angioplasty (BPA) and approved drugs. However, clinical effects cancer, which is one associated medical conditions CTEPH, remain unclear. We aimed to investigate prognosis in patients with CTEPH comorbid cancer. Methods Between January 2011 December 2022, data 264 consecutive who were treated endarterectomy, BPA, or therapy retrospectively analyzed. The...
Phlegmonous gastritis (PG) is a rare, life-threatening bacterial infection characterized by thickening of the gastric wall. We report case PG in 17-year-old male following allogeneic hematopoietic stem cell transplantation for severe aplastic anemia. Seven months after transplantation, patient presented with abdominal pain, fever, and significant wall on CT. Initial antibiotic therapy was initiated immediately. The developed multiple organ failure; however, his condition rapidly improved...
The therapeutic efficacy of extended lymph node dissection (ePLND) for intermediate- and high-risk (IR/HR) prostate cancer remains controversial. This study evaluated whether PLND improved biochemical recurrence (BCR) rates in patients with undergoing robotic-assisted radical prostatectomy (RARP) using a propensity matching method cases from two facilities. included 1002 IR/HR disease who underwent RARP at facilities equivalent surgical techniques hospital size but different ePLND policies...
Abstract Background Fall-related efficacy has been found to be associated with both falls and fall risk factors such as physical performance. The aim of the present study was clarify whether fall-related is, independent performance other potential factors, future in community-dwelling older people. Methods participants were 237 Japanese people aged 65 years over who living independently their community. assessed at baseline using short version Falls Efficacy Scale-International (short FES-I)...
Abstract Background The COVID-19 outbreak might have had several effects on older adults; however, much of the previous research only included self-report, cross-sectional, and online-survey data in early stage pandemic. We conducted a face-to-face survey before after pandemic investigated influence functions to distinguish between changes due aging using linear mixed model. Methods A total 8 longitudinal surveys were from 2016 2022. Physical function was assessed by weight, body mass index,...
A 78-year-old Japanese man presented to the emergency department with a sore throat and fever that worsened over 3 weeks. tonsil biopsy led diagnosis of pleomorphic mantle cell lymphoma (MCL) had infiltrated right adrenal gland, inferior vena cava, atrium (RA). Although patient's cardiac tumor high mobility, his hemodynamic state was stable, he did not present fatal arrhythmia. Therefore, we first introduced chemotherapy. However, patient developed recurrent pulmonary embolisms (PEs) died...
A bstract : To improve the functional recovery of injured skeletal muscle, we have focused our efforts on both enhancement muscle regeneration and prevention fibrosis. The polypeptide cytokine/growth factor relaxin can inhibit fibrous tissue formation in many tissues. As a member insulin‐like growth family, also is potential stimulator regeneration. In current experiment, examined antifibrotic effect muscle. We investigated if injection would influence after injury. Our results demonstrate...
Thymoma is a relatively rare tumour and uniquely associated with autoimmune diseases such as myasthenia gravis (MG). However, the factors involved in prognosis of thymoma remain under discussion.We retrospectively reviewed 162 patients who underwent extended thymectomy via median sternotomy for at our institute from 1976 to 2009. The histological subtype was classified according World Health Organization (WHO) classification system. Survival analysis performed using Kaplan-Meier method Cox...
Fall-related self-efficacy and gait function are known to be associated. However, whether the interaction between fall-related affects future falls has not been investigated. The aim of this study was investigate effect spatiotemporal parameters on occurrence in community-dwelling older people. A total 265 elderly persons (age ≥ 65 years) living independently community were recruited. For function, at usual maximum effort paces measured using a 2.4-m walkway system with embedded pressure...
Remimazolam is an ultra-short-acting benzodiazepine that has minimal hemodynamic effects and useful for early extubation after cardiac surgery. We present a case of elderly patient with severe aortic stenosis (AS) who underwent surgical valve replacement (AVR), was extubated in the operating room, recovered quickly without postoperative delirium. An 87-year-old woman AS AVR under cardiopulmonary bypass. General anesthesia induced remimazolam 10 mg over one minute fentanyl 100 µg, maintained...
Background: The chin tuck maneuver has been suggested to increase suprahyoid muscle activation, but a method measure the strength of not established. We developed (chin strength) and examined reliability validity measurement in community-dwelling older adults. Subjects Methods: participants were 233 adults aged ≥65 years without dysphagia or physical disability. Chin was measured twice consecutively using device, reproducibility analyzed intraclass correlation coefficients (ICCs). In...