A5017834776- Gastric Cancer Management and Outcomes
- Metastasis and carcinoma case studies
- Inflammatory Biomarkers in Disease Prognosis
- Nutrition and Health in Aging
- Esophageal Cancer Research and Treatment
- Esophageal and GI Pathology
- Cancer Research and Treatments
- Colorectal Cancer Treatments and Studies
- Colorectal Cancer Surgical Treatments
- Gastrointestinal Tumor Research and Treatment
- RNA modifications and cancer
- Bariatric Surgery and Outcomes
- Pancreatic and Hepatic Oncology Research
- RNA and protein synthesis mechanisms
- Nutritional Studies and Diet
- Colorectal and Anal Carcinomas
- RNA Research and Splicing
- Radiomics and Machine Learning in Medical Imaging
- Helicobacter pylori-related gastroenterology studies
- Glycosylation and Glycoproteins Research
- Cancer, Lipids, and Metabolism
- Studies on Chitinases and Chitosanases
- Ovarian cancer diagnosis and treatment
Kanagawa Prefectural Hospital Organization
2023-2024
Kanagawa Cancer Center
2023-2024
Yokohama City University
2024
Background/Aim: Recently, preoperative inflammatory, immune, and nutritional statuses have attracted attention as prognostic factors in post-curative gastrectomy patients with gastric cancer (GC). The usefulness of the C-reactive protein-albumin-lymphocyte (CALLY) index a factor various cancers, has been reported. However, reports on clinical significance CALLY GC after remain inadequate. In this prospective study, we focused investigated its GC. Patients Methods: This study included 459 who...
Preoperative inflammatory and nutritional statuses have potential prognostic effects on patients with gastric cancer (GC) after curative gastrectomy. We investigated the usefulness of preoperative neutrophil-to-lymphocyte ratio/albumin ratio (NLR/Alb) in GC. Among 483 who underwent gastrectomy for GC, index (PNI), NLR, NLR/Alb were calculated using blood test data. The divided into high low PNI, groups. associations clinicopathological features, 3-year (3Y) overall survival (OS) rates,...
Background/Aim: The tryptophanyl-tRNA synthetase 1 gene (WARS1), encodes a tryptophan-tRNA involved in the amino acidification of and has been reported to be cancer cell growth, metastasis promotion, drug resistance variety cancers. This study investigated clinical significance WARS1 expression as biomarker gastric tissues obtained from patients with locally advanced (GC) who underwent radical resection. Patients Methods: GC adjacent normal mucosa 253 pStage II/III curative resection was...
Background/Aim: Radical resection after preoperative adjuvant chemotherapy (NAC) is a standard treatment for patients with locally advanced esophageal squamous cell carcinoma (LAESCC), but its outcome remains unsatisfactory. In order to develop personalized program LAES, we herein compared the survival prediction utility of five pre-NAC nutritional, inflammatory, and immune indexes in LAESCC. Patients Methods: We evaluated 203 LAESCC who underwent radical NAC from January 2011 September 2019...
The prognostic significance of inflammation, immune response and nutritional status in patients with cancer is well-documented. advanced lung inflammation index (ALI) has emerged as a novel indicator, reflecting both status. This study aimed to assess the relevance preoperative ALI gastric (GC). Data 459 who underwent curative gastrectomy for GC between December 2013 November 2017 at Kanagawa Cancer Center (Yokohama, Japan) were retrospectively analyzed. Preoperative was calculated from...
Trifluridine/tipiracil (FTD/TPI) is an anticancer-agent that administered as third-line or later chemotherapy for metastatic gastric/gastroesophageal junction cancer (mGC/GEJC). Although inflammatory and nutritional statuses have attracted attention prognostic factors patients with mGC/GEJC in this therapy, their usefulness has not been fully clarified. Thus, study investigated the clinical significance of index (PNI), neutrophil/lymphocyte ratio (NLR), NLR/serum albumin (Alb) FTD/TPI.This...
Irinotecan and trifluridine/tipiracil (FTD/TPI) are fourth-line treatment options after third-line nivolumab for advanced gastric cancer (AGC). However, the efficacy safety of irinotecan FTD/TPI in setting remains unclear. This study aimed to evaluate nivolumab.We identified 137 AGC patients treated with as our institute between October 2017 July 2021. Of these, we recruited 19 who initiated 23 until September 2021.The median overall survival was 5.83 months 6.31 FTD/TPI. Median...
Trifluridine/tipiracil (FTD/TPI) is an oral anticancer agent used as a third- or later-line treatment for patients with metastatic gastric cancer/gastroesophageal junction cancer (mGC/GEJC). The C-reactive protein-to-serum albumin ratio (CAR) inflammation-based prognostic marker in cancer. This retrospective study evaluated CAR's clinical significance factor 64 mGC/GEJC administered FTD/TPI therapy. Patients were categorized into high- and low-CAR groups based on pre-treatment blood data....
Background/Aim: Radical esophagectomy after preoperative neoadjuvant chemotherapy (NAC) is the standard treatment for locally advanced esophageal squamous cell carcinoma (ESCC). However, careful selection required when considering organ function in elderly patients. Prealbumin, a rapid turnover protein, short-term dynamic nutritional index, and its relationship with long-term postoperative survival various cancers has been previously reported. association between serum prealbumin level...
Background/Aim: Dietary intake (DI) loss after gastrectomy is a serious problem for patients with gastric cancer. This study compared the dietary surgery in early cancer who received laparoscopic distal (LDG) versus those underwent conventional open (ODG). Patients and Methods: was prospective, observational enrolling assessed using food frequency questionnaire eighty-two items (FFQW82) at nutritional counseling before one three months surgery. Results: A total of 118 were included. Among...
Abstract Background Identifying the most effective postoperative surveillance interval in patients with gastric cancer (GC) remains challenging. To elucidate a logical and schedule, we analyzed GC recurrence risk trends after gastrectomy using hazard function. Methods We retrospectively reviewed medical records of 2503 who underwent curative resection between 2000 2018. examined over time influence clinicopathological variables on it. Results Overall, recurred 291 (11.6%) median 64.6 months....
Laparoscopic distal gastrectomy (LDG) is the standard treatment for gastric cancer, during which laparoscopic Billroth I anastomosis technique, also known as delta-shaped (DA), widely performed. This study aimed to evaluate differences in short- and long-term symptoms between DA traditional circular (CA) techniques.
Background/Aim: This study aimed to compare dietary intake (DI) after gastrectomy for gastric cancer between patients with (C group) and without (NC postoperative surgical complications. Patients Methods: prospective observational enrolled who underwent cancer. DI was assessed using a food frequency questionnaire 82 items (FFQW82) during nutritional counseling before surgery at one three months surgery. Results: A total of 225 participated in this study. Of the patients, 193 had no...
Background/Aim: This study aimed to investigate the differences in postoperative dietary intake (DI) loss between men and women after radical resection for early gastric cancer (GC), identify effective nutritional support both sexes. Patients Methods: prospective, observational enrolled patients who underwent gastrectomy GC. DI was assessed using food frequency questionnaire containing 82 items (FFQW82) during counseling before surgery one three months postoperatively. Results: The median...
The Inflammatory Burden Index (IBI) has been reported as a novel prognostic indicator in several cancers and diseases. However, research on the IBI patients with gastric cancer (GC) after gastrectomy is insufficient. This study investigated utility of preoperative GC.
Abstract Introduction Currently, regarding stage IVB esophageal cancer treatment, the treatment guideline in JAPAN was revised 2022 based on results of two phase III trials, KN590 and CM648, Nivolumab+Chemo Nivolumab+Ipilimumab would be used as 1st line treatment. Subject NIVO+Chemo19NIVO+Ipilimumab (IPI)17 Before February 2024, a total 160 cases unresectable/recurrent squamous cell carcinoma have been treated using IO, IO+Chemo, IO+IO at our institute. 19 were with NIVO+Chemo 17 NIVO+IPI We...
The function of the S-100 protein family member hornerin (HRNR) in gastric cancer (GC) tissues is largely unknown. We researched clinical significance HRNR expression GC patients with pathological (p)Stage II/III after curative resection.
Granzyme B (GZMB) is mainly produced by natural killer (NK) cells and activated CD8-positive T to induce tumor cell apoptosis. We analyzed the significance of GZMB expression in gastric cancer (GC) tissues from patients with pathological (p)Stage II/III GC after curative resection.
Background/Aim: Intraoperative blood loss (IBL) has been reported to decrease survival after surgical resection of some malignancies; however, there are few reports on the effects IBL recurrence and in locally advanced esophageal cancer. Therefore, we investigated relationship between postoperative overall patients who underwent surgery for Patients Methods: One hundred ninety-eight with cancer preoperative adjuvant chemotherapy curative as standard treatment were included this study. Based...
Background/Aim: The asialoglycoprotein receptor 2 gene (ASGR2) encodes a subunit of the receptor, transmembrane protein, which has recently been reported to be involved in gastric cancer (GC) progression. This study aimed investigate clinical significance ASGR2 expression GC tissues patients with locally advanced (LAGC) after curative resection. Patients and Methods: was measured adjacent normal mucosa 253 pStage II/III who underwent resection, by using quantitative polymerase chain...
Background/Aim: Chitinase-3-like protein 1 (CHI3L1), encoded by CHI3L1, is thought to be involved in growth, invasion, migration, and resistance chemotherapy cancer. This study aimed investigate the clinical significance of CHI3L1 expression as a biomarker gastric cancer (GC) tissues patients with locally advanced GC after curative resection. Patients Methods: Quantitative polymerase chain reaction (PCR) was used determined adjacent normal mucosa 253 pStage II/III who underwent We compared...
Abstract Background Patients with advanced esophageal cancer may have dysphagia and weight loss from the first visit, it is necessary to evaluate their nutritional status before starting treatment, especially for preoperative patients. On other hand, since 2018, global diagnostic criteria malnutrition, GLIM criteria, been proposed define malnutrition its severity. Purpose The aim of study examine impact severity assessment using at time visit in patients on short-term prognosis (length...
Abstract Background:
A new modified nutritional risk index (mNRI), calculated using serum albumin (g/l)+body mass (BMI) [weight (kg_/height
Background/Aim: Pregnancy zone protein (PZP), encoded by PZP, belongs to the α-2-macroglobulin superfamily, and plays an important role in inflammatory responses immune cell activation cancer. However, relationship between gastric cancer (GC) PZP is poorly studied. This study investigated clinical significance of expression GC tissues patients with locally advanced after curative resection. Patients Methods: Using quantitative polymerase chain reaction, we measured adjacent normal mucosa 253...