A5051084652- Neuroinflammation and Neurodegeneration Mechanisms
- Intensive Care Unit Cognitive Disorders
- Long-Term Effects of COVID-19
- Advanced Glycation End Products research
- Anesthesia and Neurotoxicity Research
- Tryptophan and brain disorders
- Chemokine receptors and signaling
- Diet, Metabolism, and Disease
- Immune responses and vaccinations
- Diet and metabolism studies
- Immune cells in cancer
Radboud University Nijmegen
2021-2024
Radboud University Medical Center
2021-2024
Radboud Institute for Molecular Life Sciences
2021-2022
Cognitive deficits are increasingly recognized as a long-term sequela of severe COVID-19. The underlying processes and molecular signatures associated with these neurological sequalae COVID-19 remain largely unclear, but may be related to systemic inflammation-induced effects on the brain. We studied inflammation-brain interplay its relation development cognitive impairment in patients who survived Trajectories inflammation neuroaxonal damage blood biomarkers during ICU admission were...
Long-term cognitive performance data in former critically ill COVID-19 patients are sparse. Current evidence suggests that decline is related to neuroinflammation, which might be attenuated by anti-inflammatory therapies. The objective of this prospective cohort study was long term outcomes following severe and the relation Prospective observational survived an intensive care unit (ICU) admission due COVID-19. Six months after hospital discharge, we extensively assessed both functioning...
Introduction Postoperative cognitive dysfunction occurs frequently after coronary artery bypass grafting (CABG). The underlying mechanisms remain poorly understood, but neuroinflammation might play a pivotal role. We hypothesise that systemic inflammation induced by the surgical trauma could activate innate immune (glial) cells of brain. This lead to an exaggerated neuroinflammatory cascade, resulting in neuronal and loss cells. Therefore, aims this study are assess vivo presurgery...
Major surgery such as coronary artery bypass grafting (CABG) is associated with an increased post-operative risk of atherosclerotic cardiovascular events. Cells the innate immune system can adopt a long-lasting pro-inflammatory and atherogenic phenotype after brief exposure to exogenous or endogenous inflammatory stimuli, process called "trained immunity". We hypothesized that surgery-induced inflammation leads sustained alterations in monocyte function, which promote subsequent occurrence...