A5066195949- Advanced Neuroimaging Techniques and Applications
- Advanced MRI Techniques and Applications
- Multiple Sclerosis Research Studies
- Cerebrovascular and Carotid Artery Diseases
- Acute Ischemic Stroke Management
- Functional Brain Connectivity Studies
- Neurological Disease Mechanisms and Treatments
- RNA regulation and disease
- MRI in cancer diagnosis
- Cerebrovascular and genetic disorders
- Systemic Lupus Erythematosus Research
- Ultrasound and Hyperthermia Applications
- Alzheimer's disease research and treatments
- Dementia and Cognitive Impairment Research
- Peripheral Neuropathies and Disorders
- Radiomics and Machine Learning in Medical Imaging
- Intracerebral and Subarachnoid Hemorrhage Research
- NMR spectroscopy and applications
- Parkinson's Disease Mechanisms and Treatments
- Moyamoya disease diagnosis and treatment
- Neuroinflammation and Neurodegeneration Mechanisms
- Electron Spin Resonance Studies
- Ultrasound Imaging and Elastography
- Advanced NMR Techniques and Applications
- Advanced X-ray and CT Imaging
Medical University of Graz
2016-2025
University of Graz
2002-2024
BioTechMed-Graz
2021-2024
Inserm
2014-2022
Centre de Recherche Jean Pierre Aubert
2022
Massachusetts General Hospital
2022
Centre Hospitalier Universitaire de Lille
2022
Harvard University
2022
Université de Lille
2022
Bar-Ilan University
2019
Quantitative susceptibility mapping (QSM) is a novel technique which allows determining the bulk magnetic distribution of tissue in vivo from gradient echo resonance phase images. It commonly assumed that paramagnetic iron predominant source variations gray matter as many studies have reported reasonable correlation with brain concentrations vivo. Instead performing direct comparisons, however, all these used putative hallmark study by Hallgren and Sourander (1958) for their analysis....
To investigate the relationship between transverse relaxation rates R2 and R2*, most frequently used surrogate markers for iron in brain tissue, chemically determined concentrations.This study was approved by local ethics committee, informed consent obtained from each individual's next of kin. Quantitative magnetic resonance (MR) imaging performed at 3.0 T seven human postmortem brains situ (age range death, 38-81 years). Following extraction, concentrations were with inductively coupled...
Abstract Neurofilament light (NfL) protein is a marker of neuro-axonal damage and can be measured not only in cerebrospinal fluid but also serum, which allows for repeated assessments. There still limited knowledge regarding the association serum NfL (sNfL) with age subclinical morphologic brain changes their dynamics normal population. We sNfL by single molecule array (Simoa) assay 335 individuals participating population-based cohort study after mean follow-up time 5.9 years (n = 103)....
Abstract White matter lesions progress over time, but the clinical consequences are widely unknown. Three‐hundred twenty‐nine elderly community‐dwelling volunteers underwent serial magnetic resonance imaging scanning and cognitive testing at baseline 3‐ 6‐year follow‐up. We measured changes in white lesion brain parenchymal volumes. After 6 years, median increase load was 0.2cm 3 (interquartile range [IQR], 0.0–0.80cm ) with a maximum of 31.4cm . The loss volume 2.3% (IQR, 1.13–3.58%)....
<b>Objectives: </b> To determine the rate of brain atrophy in neurologically asymptomatic elderly and to investigate impact baseline variables including conventional cerebrovascular risk factors, <i>APOE</i> ε4, white matter hyperintensity (WMH) on its progression. <b>Methods: We assessed parenchymal fraction at subsequent annual volume changes over 6 years for 201 participants (F/M = 96/105; 59.8 ± 5.9 years) Austrian Stroke Prevention Study from 1.5-T MRI scans using SIENA (structural...
Objective To establish a fully automated, robust imaging marker for cerebral small vessel disease (SVD) and related cognitive impairment that is easy to implement, reflects burden, strongly associated with processing speed, the predominantly affected domain in SVD. Methods We developed novel magnetic resonance based on diffusion tensor imaging, skeletonization of white matter tracts, histogram analysis. The (peak width skeletonized mean diffusivity [PSMD]) was assessed along conventional SVD...
<h3>Objective</h3> To determine whether brain atrophy and lesion volumes predict subsequent 10 year clinical evolution in multiple sclerosis (MS). <h3>Design</h3> From eight MAGNIMS (MAGNetic resonance Imaging MS) centres, we retrospectively included 261 MS patients with MR imaging at baseline after 1–2 years, Expanded Disability Status Scale (EDSS) scoring years. Annualised whole atrophy, central rates T2 were calculated. Patients categorised by diagnosis as primary progressive (n=77),...
Purpose To apply quantitative susceptibility mapping (QSM) in the basal ganglia of patients with multiple sclerosis (MS) and relate findings to R2* regard sensitivity for clinical morphologic measures disease severity. Materials Methods The local ethics committee approved this study, all subjects gave written informed consent. Sixty-eight (26 clinically isolated syndrome, 42 relapsing-remitting MS) 23 control underwent 3-T magnetic resonance (MR) imaging. Susceptibility maps were...
As indicated by several recent studies, magnetic susceptibility of the brain is influenced mainly myelin in white matter and iron deposits deep nuclei. Myelination deposition evolve both spatially temporally. This evolution reflects an important characteristic normal development ageing. In this study, we assessed changes regional human vivo examining developmental ageing process from 1 to 83 years age. The over lifespan was found display differential trajectories between gray matter....
Background and Purpose— Strokes have especially devastating implications if they occur early in life; however, only limited information exists on the characteristics of acute cerebrovascular disease young adults. Although risk factors manifestation atherosclerosis are commonly associated with stroke elderly, recent data suggests different causes for young. We initiated prospective, multinational European study Stroke Young Fabry Patients (sifap) to characterize a cohort patients. Methods—...
Quantitative susceptibility mapping (QSM) and R2* relaxation rate have demonstrated increased iron deposition in the substantia nigra of patients with idiopathic Parkinson's disease (PD). However, findings other subcortical deep gray matter nuclei are converse sensitivity QSM for morphological changes their relation to clinical measures severity has so far been investigated only sparsely.The local ethics committee approved this study all subjects gave written informed consent. 66 58 control...
Anticipating the burden of intracerebral haemorrhage is crucial for proactive management and building resilience against future health challenges. Prior forecasts are based on population demography to a lesser extent epidemiological trends. This study aims utilise selected modifiable risk factors socio-demographic indicators forecast incidence mortality in Europe between 2019 2050.
Direct oral anticoagulants (DOACs) reduce the rate of thromboembolism in patients with atrial fibrillation but benefits and risks survivors intracerebral haemorrhage are uncertain. We aimed to determine whether DOACs risk ischaemic stroke without substantially increasing recurrent haemorrhage. PRESTIGE-AF is a multicentre, open-label, randomised, phase 3 trial conducted at 75 hospitals six European countries. Eligible were aged 18 years or older spontaneous haemorrhage, fibrillation, an...
White matter hyperintensities and lacunes are among the most frequent abnormalities on brain magnetic resonance imaging. They commonly related to cerebral small vessel disease associated with both stroke dementia. We examined spatial relationships between incident white these findings information vascular anatomy study possible mechanistic links two lesion types. Two hundred seventy-six patients autosomal dominant arteriopathy subcortical infarcts leukoencephalopathy (CADASIL), a genetically...
To explore whether serum neurofilament light chain protein (NfL) levels are increased in patients with MRI-confirmed recent small subcortical infarcts (RSSI) compared to healthy controls and determine the subsequent course determinants of NfL a longitudinal manner.In prospectively collected group symptomatic an RSSI (n = 79, mean age 61 ± 11 years, 67% male), we analyzed brain MRI using Single Molecule Array (Simoa) assay at baseline 3 15 months after stroke. Community-dwelling age-...
The mechanisms underlying motor recovery after stroke are not fully understood. Several studies used functional MRI longitudinally to relate brain activity changes with performance gains of the upper limb therapy, but research into training-induced lower function has been relatively neglected thus far.