A5102769437- Atrial Fibrillation Management and Outcomes
- Cardiac Arrhythmias and Treatments
- Cardiac electrophysiology and arrhythmias
- Cardiac Imaging and Diagnostics
- Cardiac pacing and defibrillation studies
- Cardiovascular Function and Risk Factors
- Cardiac Fibrosis and Remodeling
- Thyroid Disorders and Treatments
- Acute Ischemic Stroke Management
- Tissue Engineering and Regenerative Medicine
- Congenital heart defects research
- Ion channel regulation and function
- Pulmonary Hypertension Research and Treatments
- Angiogenesis and VEGF in Cancer
- Cardiac Structural Anomalies and Repair
- Cardiac Valve Diseases and Treatments
- Thyroid Cancer Diagnosis and Treatment
- Cardiovascular Syncope and Autonomic Disorders
- Peptidase Inhibition and Analysis
- Venous Thromboembolism Diagnosis and Management
- Protease and Inhibitor Mechanisms
- Nitric Oxide and Endothelin Effects
- Pluripotent Stem Cells Research
- Mesenchymal stem cell research
- Mechanical Circulatory Support Devices
Alfried Krupp Hospital
2025
Klinikum Vest
2022-2023
Klinikum rechts der Isar
2023
University Hospital Münster
2019-2023
Deutsches Herzzentrum München
2023
German Center for Neurodegenerative Diseases
2016-2023
Technical University of Munich
2023
German Centre for Cardiovascular Research
2023
University Hospital Magdeburg
2023
Heinrich Heine University Düsseldorf
2016-2022
The purpose of this study was to determine whether the heart in large mammals contains cardiac progenitor cells that regulate organ homeostasis and regenerate dead myocardium after infarction. We report dog possesses a stem cell pool characterized by undifferentiated are self-renewing, clonogenic, multipotent. These clonogenic early committed progeny possess hepatocyte growth factor (HGF)–c-Met an insulin-like 1 (IGF-1)-IGF-1 receptor system can be activated induce their migration,...
Direct oral anticoagulants (DOACs) reduce the rate of thromboembolism in patients with atrial fibrillation but benefits and risks survivors intracerebral haemorrhage are uncertain. We aimed to determine whether DOACs risk ischaemic stroke without substantially increasing recurrent haemorrhage. PRESTIGE-AF is a multicentre, open-label, randomised, phase 3 trial conducted at 75 hospitals six European countries. Eligible were aged 18 years or older spontaneous haemorrhage, fibrillation, an...
Background — Cell replacement therapy with stem cells able to differentiate into cardiomyocytes has been discussed as a method for remodeling damaged myocardium. A physiological or pathophysiological situation in which this phenomenon might be relevant is not known. We studied the origin of myocardial biopsies male patients that had undergone sex-mismatched cardiac transplantation determine whether containing Y chromosome (and therefore being recipient origin) are cardiomyocytes. Methods and...
Hyperaldosteronism is associated with an increased prevalence of atrial fibrillation (AF). However, it unclear whether this the consequence altered haemodynamics or a direct aldosterone effect. It was aim study to demonstrate load-independent effects on structure and electrophysiology.Osmotic mini-pumps delivering 1.5 µg/h were implanted subcutaneously in rats (Aldo). Rats without treatment served as controls. After 8 weeks, surface electrocardiogram, inducibility AF, pressures recorded...
Up to 40% of patients demonstrate endoscopically detected asymptomatic esophageal lesions (EDEL) after atrial fibrillation ablation.Patients undergoing first ablation and postinterventional endoscopy were included in the study. Occurrence perforating complications during follow-up was related documented EDEL (category 1: erythema/erosion; category 2: ulcer). In total, 1802 underwent procedure between January 2013 August 2016 at our institution. Out this group, 832 (506 male patients, 61%;...
TeleCheck-AF is a multicentre international project initiated to maintain care delivery for patients with atrial fibrillation (AF) during COVID-19 through teleconsultations supported by an on-demand photoplethysmography-based heart rate and rhythm monitoring app (FibriCheck®). We describe the characteristics, inclusion rates, experiences from participating centres according infrastructure as well characteristics recruited patients.Three surveys exploring centre (n = 25), 23), patient 826)...
Abstract Artificial intelligence (AI) is developing rapidly in the medical technology field, particularly image analysis. ECG-diagnosis an analysis sense that cardiologists assess waveforms presented a 2-dimensional image. We hypothesized AI using convolutional neural network (CNN) may also recognize ECG images and patterns accurately. used PTB database consisting of 289 ECGs including 148 myocardial infarction (MI) cases to develop CNN MI ECG. Our model, equipped with 6-layer architecture,...
Introduction “Single shot” ablation devices to treat symptomatic atrial fibrillation have been engineered over the last years. Safety and efficacy also includes subclinical complications only detected with esophageal endoscopy or cerebral MRI in asymptomatic patients. We studied acute safety profile of a novel multipolar irrigated RF catheter (nMARQ™ ) . Methods Results Forty‐three patients underwent pulmonary vein isolation (PVI) using device. Patient baseline procedural characteristics...
Abstract CD117-positive cells contributing to cardiac cell turnover in normal and pathological conditions have recently been described adult human heart. Since the precise spatial temporal expression of extracellular matrix proteins their receptors is critical for organ formation, we compared distribution primitive hearts with ischemic cardiomyopathy, respect localization laminin integrin isoforms. In hearts, were significantly more numerous than hearts. They localized mainly atria up...
Although hyperthyroidism predisposes to atrial fibrillation, previous trials have suggested decreased triiodothyronine (T3) concentrations be associated with postoperative fibrillation (POAF). Therapy thyroid hormones (TH), however, did not reduce the risk of POAF. This study reevaluates relation between hormone status, electromechanical function and POAF.Thirty-nine patients sinus rhythm no history or disease undergoing cardiac surgery were prospectively enrolled. Serum thyrotropin, free...
Oesophageal probes to monitor luminal oesophageal temperature (LET) during atrial fibrillation (AF) catheter ablation have been proposed, but their effects remain unclear. Aim of this study is evaluate the an probe with insulated thermocouples. Patients symptomatic, drug-refractory paroxysmal or persistent AF who underwent left radiofrequency (RF) were prospectively enrolled. ablated using a single-tip RF contact force catheter. An intraluminal was used in Group 1. In 2, patients without LET...
A variant in the SLC4A3 anion exchanger has been identified as a novel cause of short QT syndrome (SQTS), but clinical importance SQTS or sudden cardiac death remains unknown.
Inhibition of the angiotensin-converting enzyme (ACE) prevents maladaptive cardiac remodelling. Endothelial progenitor cells (EPC) from bone marrow contribute to endothelial repair and neovascularization, effects that are potentially important during We hypothesized ACE inhibitors may exert beneficial pressure-induced myocardial hypertrophy by regulating cell function. In C57/Bl6 mice, development induced transaortic constriction (TAC) for 5 weeks was reduced ramipril, mg/kg p.o.,...
Atrial Conduction Time Background Recent studies identified total atrial conduction time (TACT) as an independent and powerful predictor of new‐onset fibrillation (AF). The purpose this study was to assess the association between degree fibrosis, TACT, frequency postoperative (POAF) among patients undergoing cardiac surgery. Methods Results Sixty in sinus rhythm (mean ± SD age 66 10 years; 22% women) without a history AF surgery were prospectively enrolled. TACT measured preoperatively left...
Atrial fibrillation (AF) is associated with thromboembolic events. Currently, the CHA2DS2-VASc score recommended for risk stratification in non-valvular AF patients. However, recent data suggested a potential role of atrial remodelling on thromboembolism. This study aimed to assess association between left low-voltage area (LVA) and history clinical manifest as well subclinical silent cerebral ischaemia (SCI) Two-hundred patients [64 ± 10.5 years, 75 women (37.5%)] symptomatic paroxysmal (n...
Inhibition of proteolytic MMP activity could be a therapeutic approach to prevent ventricular dilatation by diminishing collagen matrix turnover and interstitial fibrosis. We investigated the time-course MMP/TIMP during transition from hypertrophy in transgenic mice with myocyte overexpression human β1-adrenergic receptor (β1TG). These β1TG were studied at 3 (normal function), 5 (hypertrophy) 12 (ventricular dilatation) months age compared age-matched controls (WT). Picro Sirius red staining...
AimThe regulation of angiogenesis in the hypertrophied overloaded heart is incompletely understood. Bone-marrow-derived progenitor cells have been shown to contribute endothelial homeostasis, repair, and new blood vessel formation. We therefore studied effects pressure overload on cells.