A5071180868- Aortic Disease and Treatment Approaches
- Cardiac Valve Diseases and Treatments
- Aortic aneurysm repair treatments
- Tissue Engineering and Regenerative Medicine
- Cardiac and Coronary Surgery Techniques
- Acute Myocardial Infarction Research
- Transplantation: Methods and Outcomes
- Mechanical Circulatory Support Devices
- Antiplatelet Therapy and Cardiovascular Diseases
- Cardiac, Anesthesia and Surgical Outcomes
- Aortic Thrombus and Embolism
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Congenital Heart Disease Studies
- Infectious Aortic and Vascular Conditions
- Cardiac Fibrosis and Remodeling
- Infective Endocarditis Diagnosis and Management
- Blood transfusion and management
- Cerebrovascular and Carotid Artery Diseases
- Coronary Interventions and Diagnostics
- Venous Thromboembolism Diagnosis and Management
- RNA modifications and cancer
- Congenital heart defects research
- Acute Kidney Injury Research
- Cardiac Structural Anomalies and Repair
- Cardiovascular Health and Disease Prevention
University of Campania "Luigi Vanvitelli"
2015-2024
Ospedale Monaldi
2007-2019
University of Naples Federico II
2008-2018
This study aimed to describe the features and identify predictors of ascending aorta dilatation in patients with congenital bicuspid aortic valve (BAV).In 280 adult isolated BAV undergoing echocardiography, multivariate logistic regression models, including clinical echocardiographic variables, were developed predict (aortic ratio exceeding 1.1) at both root level. Factors predicting aneurysm surgical indication also investigated. Classification tree models used factors influencing...
Clinical evidence in coronary surgery is usually derived from retrospective, single institutional series. This may introduce significant biases the analysis of critical issues treatment these patients. In order to avoid such methodological limitations, we planned a European multicenter, prospective study on artery bypass grafting, E-CABG registry. The registry multicenter and its data are prospectively collected 13 centers cardiac university community hospitals located six countries...
Different methods to classify the anatomical configurations of aorta with bicuspid aortic valve (BAV) have been proposed. We aimed test them in terms descriptive power (i.e. capability identify different clusters patients unique associations anatomo-clinical features) and possible prognostic significance. A consecutive echocardiographic series 696 BAV (mean age 48 ± 16 years, male:female ratio 3:1) was analysed. Three schemes for classification patterns dimensions were compared. One defined...
The optimal timing of discontinuation ticagrelor before cardiac surgery is controversial.To evaluate the safety preoperative use with or without aspirin in patients acute coronary syndromes (ACS) undergoing isolated artery bypass grafting (CABG) compared alone.This prospective, multicenter clinical trial was performed at 15 European centers surgery. Participants were ACS CABG from Multicenter Study on Coronary Artery Bypass Grafting (E-CABG) registry between January and September 2015.Before...
Abstract CD117-positive cells contributing to cardiac cell turnover in normal and pathological conditions have recently been described adult human heart. Since the precise spatial temporal expression of extracellular matrix proteins their receptors is critical for organ formation, we compared distribution primitive hearts with ischemic cardiomyopathy, respect localization laminin integrin isoforms. In hearts, were significantly more numerous than hearts. They localized mainly atria up...
Bicuspid aortic valve (BAV)-related aortopathy is increasingly recognized to be a heterogeneous disease entity, although the surgical approach, from indications techniques, still standard rather than individualized. We aimed define determinants of dilatation in BAV patients stratified according morphotype. A consecutive echocardiographic series 622 was analysed. Among demographic (age, sex), anthropometric (height, weight, body surface area, mass index), clinical (associated diseases) and...
Previous studies on BAV (bicuspid aortic valve)-related aortopathy, whose aetiology is still debated, have focused mainly severe dilatations. In the present study, we aimed to detect earlier signs of aortopathy. Specimens were collected from ‘concavity’ (lesser curvature) and ‘convexity’ (greater mildly dilated AAs (ascending aortas; diameter ≤4 cm) with stenotic TAV (tricuspid valve) or donor normal aortas. submitted morphometry, immunohistochemistry differential gene-expression analysis,...
Data regarding risks and consequences of acute kidney injury (AKI) after cardiac transplantation are dismissingly few unclear. This study defined the incidence, risk factors prognostic implication AKI in a single-center cohort operated on between January 1999 December 2008.Data from 307 consecutive recipients (mean age: 47.42 ± 13.58, 20.5% female, 18.9% diabetics, 19.5% with previous operations, 26.4% hospitalized, 78.4 33.7 ml min(-1) preoperative glomerular filtration rate (eGFR)) were...
Rationale: The pathogenesis of bicuspid aortic valve (BAV)–associated aortopathy is poorly understood, and no prognostic biomarker currently available. Objective: We aimed to identify putative circulating biomarkers pathogenetically prognostically linked aortopathy. Methods Results: By reverse transcription polymerase chain reaction, we evaluated gene expression variations (versus normal aorta) transforming growth factor-β1 (TGF-β1), connective tissue factor, matrix metalloproteinase-2...
Cardiac tissue regeneration is guided by stem cells and their microenvironment. It has been recently described that both cardiac stem/primitive extracellular matrix (ECM) change in pathological conditions. This study describes the method for production of ECM typical adult human heart normal conditions (ischemic disease) highlights potential use fibroblast-derived vitro studies interactions between components primitive responsible regeneration. Fibroblasts isolated from with ischemic...
BACKGROUND Excessive bleeding and blood transfusion are associated with adverse outcome after cardiac surgery, but their mechanistic effects difficult to disentangle in patients increased operative risk. This study aimed evaluate the incidence prognostic impact of products low‐risk undergoing coronary artery bypass grafting (CABG). STUDY DESIGN AND METHODS Sixteen tertiary European centers surgery contributed prospective registry CABG (E‐CABG). The severity was defined by E‐CABG...
Objective: The aim of this study was to prospectively evaluate frequency, characteristics, and predictors nosocomial infections (NI) in a tertiary care centre. Methods: Study population included 925 patients (mean age 62.3 ± 12.5, 32.3% females, 22.9% diabetics, 6.8% with previous cardiac procedures) operated on between June 2005 December 2006 (CABG 48.72%, valvular procedures 30.05%, thoracic aortic 10.9%, heart transplantations 3.78% miscellanea 6.55%, procedure status: elective 72.9%,...
Abstract Objective: To develop a risk score for deep sternal wound infection (DSWI) after isolated coronary artery bypass grafting (CABG). Design: Multicenter, prospective study. Setting: Tertiary-care referral hospitals. Participants: The study included 7,352 patients from the European multicenter (E-CABG) registry. Intervention: Isolated CABG. Methods: An additive (the E-CABG DSWI score) was estimated derivation data set (66.7% of patients), and its performance assessed in validation...