A5061924350- Neurological disorders and treatments
- Parkinson's Disease Mechanisms and Treatments
- Genetic Neurodegenerative Diseases
- Spine and Intervertebral Disc Pathology
- Botulinum Toxin and Related Neurological Disorders
- Advanced MRI Techniques and Applications
- Neuroscience and Neural Engineering
Medical University of Graz
2016-2023
Quantitative susceptibility mapping (QSM) and R2* relaxation rate have demonstrated increased iron deposition in the substantia nigra of patients with idiopathic Parkinson's disease (PD). However, findings other subcortical deep gray matter nuclei are converse sensitivity QSM for morphological changes their relation to clinical measures severity has so far been investigated only sparsely.The local ethics committee approved this study all subjects gave written informed consent. 66 58 control...
ABSTRACT Background In a small group of patients, we have previously shown that combination electrophysiological tests was able to distinguish functional (psychogenic) tremor and organic with excellent sensitivity specificity. Objectives This study aims validate an test battery as tool diagnose patients “laboratory‐supported” level certainty. Methods For this prospective data collection study, recruited 38 new (mean age 37.9 ± 24.5 years; mean disease duration 5.9 9.0 years) 73 55.4 25.4...
We investigated R2* relaxation rates as a marker of iron content in the substantia nigra patients with common tremor disorders and explored their diagnostic properties.Mean nigral were measured 40 tremor-dominant Parkinson's disease (PD), 15 dystonia, 25 essential tremor, healthy controls.Tremor-dominant PD had significantly higher values (34.1 ± 5.7) than those dystonia (30.0 3.9), (30.6 4.8), controls 2.8). An threshold 31.15 separated from sensitivity specificity 67.5% 72%. The for...
BackgroundAn objective evaluation of tremor severity is necessary to document the course disease, efficacy treatment, or interventions in clinical trials. Most available quantification devices are complex, immobile, not validated.New methodWe used TREMITAS-System that comprises a pen-shaped sensor for quantification. The Power Main Peak and Total were as surrogate markers amplitude. Tremor was assessed by relevant subscores MDS-UPDRS TETRAS rating scales 14 patients with Parkinson's disease...
Abstract Background and purpose Quantification of neurofilament light chain protein in serum (sNfL) enables the neuro‐axonal damage peripheral blood to be reliably assessed monitored. There is a long‐standing debate whether essential tremor represents ‘benign’ syndrome or it linked neurodegeneration. This study aims investigate sNfL concentrations compared healthy controls (cross‐sectionally longitudinally) assess associated with motor nonmotor markers disease progression. Methods Data...
Background: Cervical dystonia is the most common form of focal dystonia. The frequency and pattern degenerative changes cervical spine in patients with their relation to clinical symptoms remain unclear as no direct comparison healthy controls has been performed yet. Here, we used magnetic resonance imaging (MRI) investigate (1) whether structural abnormalities are more compared age-matched controls, (2) if there predictors for on MRI, (3) calculate inter-rater reliability respective...