A5021360656- Neurological disorders and treatments
- Multiple Sclerosis Research Studies
- Genetic Neurodegenerative Diseases
- Neurological Disorders and Treatments
- Bipolar Disorder and Treatment
- Mitochondrial Function and Pathology
- Obsessive-Compulsive Spectrum Disorders
- Cerebrovascular and genetic disorders
- Autoimmune and Inflammatory Disorders Research
- Hearing Loss and Rehabilitation
- Neurological Disease Mechanisms and Treatments
- Parkinson's Disease Mechanisms and Treatments
- Fibromyalgia and Chronic Fatigue Syndrome Research
- RNA regulation and disease
- Neuroinflammation and Neurodegeneration Mechanisms
- Neurological diseases and metabolism
Medical University of Graz
2022-2025
Investigation on specific biomarkers for diagnostic or prognostic usage in mental diseases and especially bipolar disorder BD seems to be one outstanding field current research. Serum neurofilament light (sNfL), a marker neuro-axonal injury, is increased various acute chronic neurological disorders, but also neuro-psychiatric conditions, including affective disorders. The aim of our study was determine potential relation between neuron-specific like sNfL different clinical states BD....
We aimed to determine whether transient global amnesia (TGA) is associated with alterations in central nervous system (CNS) injury biomarkers—serum neurofilament light chain (sNfL) and serum glial fibrillary acidic protein (sGFAP). In a prospective cohort of TGA patients, blood samples were obtained within 24–48 h onset (t0) 6 weeks thereafter (t1). assessed sNfL sGFAP levels using the highly sensitive single-molecule array assay calculated Z-scores adjusted for age, gender, body mass index...
Abstract Background Huntington’s disease (HD) is caused by CAG trinucleotide expansion on chromosome 4, leading to mutant Huntingtin production. Premanifest carriers show no obvious clinical signs, and early symptoms progress slowly. Fluid biomarkers like neurofilament light (NfL) glial fibrillary acidic protein (GFAP), measurable in cerebrospinal fluid serum (sNfL, sGFAP), offer potential predicting HD progression. Objective To assess the role of sGFAP sNfL different stages correlate with...
Abstract Background Limited resources often hinder regular cognitive assessment of people with multiple sclerosis (pwMS) in standard clinical care. A self-administered iPad®-based screening-tool (Processing Speed Test; PST) might mitigate this problem. Objective To evaluate the PST routine. Methods We investigated feasibility both a quiet and waiting room setting. assessed validity comparison established Symbol Digit Modalities Test (SDMT). explored associations between processing speed...
Abstract Background and purpose Quantification of neurofilament light chain protein in serum (sNfL) enables the neuro‐axonal damage peripheral blood to be reliably assessed monitored. There is a long‐standing debate whether essential tremor represents ‘benign’ syndrome or it linked neurodegeneration. This study aims investigate sNfL concentrations compared healthy controls (cross‐sectionally longitudinally) assess associated with motor nonmotor markers disease progression. Methods Data...
Abstract Background Immune cell metabolism governs the outcome of immune responses and contributes to development autoimmunity by controlling lymphocyte pathogenic potential. In this study, we evaluated metabolic profile myelin-specific murine encephalitogenic T cells, identify novel therapeutic targets for autoimmune neuroinflammation. Methods We performed metabolomics analysis on actively-proliferating cells study their overall in comparison resting cells. Metabolomics, phosphoproteomics,...
Serum glial fibrillary acidic protein (sGFAP) has been proposed as a biomarker in various neurological diseases but not yet systematically investigated patients with cerebral small vessel disease (CSVD). We explored whether sGFAP levels are increased stroke MRI-confirmed recent subcortical infarcts (RSSI) and analyzed the subsequent course determinants of longitudinally.In prospectively-collected cohort single RSSI (n = 101, mean age: 61 years, 73% men), we brain MRI using SIMOA assay at...