A5002292654- Multiple Sclerosis Research Studies
- Peripheral Neuropathies and Disorders
- Olfactory and Sensory Function Studies
- Polyomavirus and related diseases
- Systemic Lupus Erythematosus Research
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Immunotherapy and Immune Responses
- Systemic Sclerosis and Related Diseases
- Ultrasound Imaging and Elastography
- Biochemical Analysis and Sensing Techniques
- melanin and skin pigmentation
- Allergic Rhinitis and Sensitization
- Effects of Vibration on Health
- Psoriasis: Treatment and Pathogenesis
- Retinal and Optic Conditions
- Full-Duplex Wireless Communications
- Rheumatoid Arthritis Research and Therapies
- Health, Environment, Cognitive Aging
- vaccines and immunoinformatics approaches
- Reproductive System and Pregnancy
- Blood disorders and treatments
- Cerebral Venous Sinus Thrombosis
- Ocular Diseases and Behçet’s Syndrome
- Ultrasound and Hyperthermia Applications
- Skin and Cellular Biology Research
Medical University of Graz
2020-2025
Innsbruck Medical University
2017-2021
Universität Innsbruck
2017-2021
FH Campus Wien
2021
Medical University of Vienna
2020-2021
Neurology, Inc
2020
Hopitaux Civils de Colmar
2019
Peripapillary retinal nerve fibre layer (pRNFL) thickness is emerging as a marker of axonal degeneration in multiple sclerosis (MS).We aimed to prospectively assess the predictive value pRNFL for progression physical and cognitive disability relapsing-remitting MS (RRMS).In this 3-year longitudinal study on 151 RRMS patients, was measured by spectral-domain optical coherence tomography (OCT). We used proportional hazard models, correcting age, sex, disease duration, Expanded Disability...
Multiple sclerosis (MS) predominantly affects women of child-bearing potential. Pregnancy in MS is still a controversial issue lacking standardized treatment recommendations.To examine the reciprocal effects pregnancy, MS, and disease-modifying (DMT).We analyzed 387 pregnancies 239 with relapsing remitting multiple (RRMS) ⩾1 establishment diagnosis >1 year before conception, ⩾2 years follow-up after delivery. Relapse rates Expanded Disability Status Scale (EDSS) scores were compared during 2...
Background: Macular ganglion cell–inner plexiform layer (mGCIPL) is an emerging biomarker of neuroaxonal degeneration in multiple sclerosis (MS). Objective: We aimed to determine cut-off values mGCIPL thinning for discriminating between progressing and stable patients relapsing (RMS). Methods: This a 3-year prospective longitudinal study on 183 RMS with annual optical coherence tomography. Best possible baseline loss macular (aLmGCIPL) clinically (physical progression or cognitive decline)...
Abstract Background and purpose There is a lack of evidence guiding discontinuation disease‐modifying therapy (DMT) in relapsing multiple sclerosis (RMS). Thus, the objective this study was to generate validate risk score for disease reactivation after DMT RMS. Methods We drew generation validation dataset from two separate prospectively collected observational databases including RMS patients who received interferon‐β or glatiramer acetate ≥12 months, then discontinued ≥6 months had ≥2...
To investigate whether κ-free light chain (κ-FLC) index predicts multiple sclerosis (MS) disease activity independent of demographics, clinical characteristics, and MRI findings.Patients with early MS who had CSF serum sampling at onset were followed for 4 years. At baseline, age, sex, type symptoms, corticosteroid treatment, number T2 hyperintense (T2L) contrast-enhancing T1 lesions (CELs) on determined. During follow-up, the occurrence a second attack start disease-modifying therapy (DMT)...
Background and purpose Peripapillary retinal nerve fibre layer (pRNFL) thickness is a strong candidate as biomarker of axonal degeneration in multiple sclerosis (MS). The aim was to determine cut‐off value pRNFL thinning rates relapsing–remitting MS (RRMS) discriminate between stable progressing patients. Methods In this 3‐year prospective longitudinal study on 141 RRMS patients, annual (aLpRNFL) were determined by individual linear regression models. best possible discriminating clinically...
PIRA (progression independent of relapse) has emerged as a term to quantify the proportion disability worsening due non-inflammatory neurodegenerative processes in multiple sclerosis (MS).To determine impact on retinal thinning, biomarker neuroaxonal degeneration MS, comparison traditional and relapse.In 4-year, prospective observational study including 171 relapsing MS (RMS) patients, thinning was determined by annual spectral-domain optical coherence tomography measuring macular...
Inter-individual courses of multiple sclerosis (MS) are extremely variable. The objective this study was to investigate whether κ-free light chain (κ-FLC) index and serum neurofilament (sNfL) have an additive predictive value for MS disease activity.Patients with early who had cerebrospinal fluid (CSF) sampling at onset were followed four years. At baseline, age, sex, duration, number T2-hyperintense (T2L), contrast-enhancing T1 lesions (CEL) on MRI determined. During follow-up, the...
Background: A variety of disease-modifying therapies (DMTs) are now available for multiple sclerosis (MS), each with distinct efficacy and risk profiles. However, the clinical course MS varies significantly both within between individuals, optimal treatment strategy remains uncertain at group individual levels. Addressing questions about strategies through traditional randomized controlled trials is unrealistic due to large sample sizes high costs required. Instead, large-scale multicenter...
Background: Serum neurofilament light chain (sNfL) levels and peripapillary retinal nerve fiber layer (pRNFL) are both emerging biomarkers of neuro-axonal damage in multiple sclerosis (MS). However, data on the relation between sNfL pRNFL scarce. Objective: We aimed to determine with thinning a large cohort relapsing–remitting (RR) MS patients. Methods: identified 80 patients from prospective, 3-year observational study changes RRMS annual blood samples available. were measured using...
The understanding of the pathophysiology multiple sclerosis (MS) has evolved alongside characterization cytokines and chemokines in cerebrospinal fluid (CSF) serum. However, complex interplay pro- anti-inflammatory different body fluids people with MS (pwMS) their association disease progression is still not well understood needs further investigation. Therefore, aim this study was to profile a total 65 cytokines, chemokines, related molecules paired serum CSF samples pwMS at onset.Multiplex...
Background: Impaired olfactory threshold has been reported in early inflammatory phases of MS, while impaired odor identification was associated with more widespread disability. Objective: To prospectively assess the development function and its correlation relapse disability progression. Methods: In this prospective, 3-year longitudinal study on 151 MS patients 30 healthy controls, three different qualities (threshold, discrimination, identification) were quantified using Sniffin’ Sticks...
Peripapillary retinal nerve fiber layer (pRNFL) thickness and olfactory function are both emerging biomarkers in multiple sclerosis (MS). Impairment of odor identification discrimination is an irreversible feature more advanced MS suggested to be associated with neurodegeneration, while threshold a transient early, active possibly short-term inflammatory disease activity.The aim this study was validate the association (dys)function parameters course large cohort patients correlate pRNFL as...
Peripapillary retinal nerve fiber layer (pRNFL) and macular ganglion cell plus inner plexiform (GCIPL) thinning are markers of neuroaxonal degeneration in multiple sclerosis (MS), which is reduced by disease-modifying treatment (DMT). We aimed to investigate the potential pRNFL GCIPL for prediction DMT failure relapsing MS (RMS).In this 4-year prospective observational study on 113 RMS patients, were measured at initiation after 12 months (M12) 24 (M24). Treatment was defined as 6-month...
Abstract Background Limited resources often hinder regular cognitive assessment of people with multiple sclerosis (pwMS) in standard clinical care. A self-administered iPad®-based screening-tool (Processing Speed Test; PST) might mitigate this problem. Objective To evaluate the PST routine. Methods We investigated feasibility both a quiet and waiting room setting. assessed validity comparison established Symbol Digit Modalities Test (SDMT). explored associations between processing speed...
Demyelinating diseases of the central nervous system associated with autoantibodies against aquaporin-4 and myelin-oligodendrocyte-glycoprotein are mediated by different immunopathological mechanisms compared to multiple sclerosis.The purpose this study was evaluate serum cerebrospinal fluid cytokine/chemokine profiles in patients or myelin-oligodendrocyte-glycoprotein-associated demyelination sclerosis autoimmune encephalitis.Serum levels were analysed using Procartaplex Multiplex...
There is evidence that B cells play an important role in disease pathology of multiple sclerosis (MS). The aim this prospective observational study was to determine the predictive value cerebrospinal fluid (CSF) cell subtypes evolution patients with MS.128 were included between 2004 and 2012. Median follow up time 7.9 years (range 3.3-10.8 years). 10 lost follow-up. 32 clinically isolated syndrome- (CIS), 25 relapsing remitting MS- (RRMS), 2 secondary progressive (SPMS) 9 primary (PPMS)...
Background: Impairment of odor discrimination (D), identification (I), and threshold (T) are characteristic features multiple sclerosis (MS). Objective: To identify patterns gray matter concentration (GMC) associated with different qualities olfactory function. Methods: Olfactory function (T combined DI score) was measured by Sniffin’ Sticks-Test over 2 years longitudinally, T1-weighted 3-T magnetic resonance imaging (MRI) performed in 37 MS patients 18 matched healthy controls (HCs)....
Serum neurofilament light chain levels (sNfL) and impairment of olfactory function emerge as biomarkers in multiple sclerosis (MS). However, the relation between sNfL MS has not been investigated yet.We aimed to determine whether correlate with relapsing-remitting (RR) MS.We annually measured (Sniffin' Sticks test: Threshold (T) combined discrimination-identification (DI) score) 80 RRMS patients compared T DI scores.T scores significantly correlated at simultaneous measurement (-1.5 points,...