A5038313096- Multiple Sclerosis Research Studies
- SARS-CoV-2 and COVID-19 Research
- Peripheral Neuropathies and Disorders
- Systemic Lupus Erythematosus Research
- COVID-19 Clinical Research Studies
- Animal Virus Infections Studies
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Cardiac Imaging and Diagnostics
- Viral gastroenteritis research and epidemiology
- Cytokine Signaling Pathways and Interactions
- Long-Term Effects of COVID-19
- Neuroinflammation and Neurodegeneration Mechanisms
- Cardiovascular Effects of Exercise
- Rheumatoid Arthritis Research and Therapies
- Psoriasis: Treatment and Pathogenesis
- Herpesvirus Infections and Treatments
- Bone and Joint Diseases
- Cardiac tumors and thrombi
- Cardiovascular Issues in Pregnancy
- Neutropenia and Cancer Infections
- Cardiac electrophysiology and arrhythmias
- Coffee research and impacts
- Neuroendocrine regulation and behavior
- Neuroscience and Neuropharmacology Research
- Cerebrospinal fluid and hydrocephalus
Innsbruck Medical University
2015-2025
Universität Innsbruck
2020-2024
VASCage
2022-2023
University of Regensburg
2012-2019
Barts Health NHS Trust
2017
Medical University of Vienna
2015
Ludwig-Maximilians-Universität München
1958-2010
T cells play a fundamental role in the early control and clearance of many viral infections respiratory system. In SARS-CoV-2-infected individuals, lymphopenia with drastically reduced CD4+ CD8+ correlates Coronavirus disease 2019 (COVID-19)-associated severity mortality. this study, we characterized cellular humoral immune responses induced patients mild, severe critical COVID-19. Peripheral blood mononuclear 37 COVID-19 10 healthy individuals were analyzed by IFNγ ELISpot multi-color flow...
Few studies have directly compared virus-specific antibodies and their neutralizing capacity against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) wild type (WT) circulating variants of concern despite the reported high efficacy messenger RNA (mRNA)- vector-based vaccines.
SARS-CoV2 vaccination is recommended for patients with multiple sclerosis (pwMS), but response may be limited by disease-modifying-treatments (DMTs). The aim of this study was to compare the rates humoral immune and safety SARS-CoV-2 vaccines in pwMS healthy controls (HCs).In multicenter prospective on 456 116 HCs, SARS-CoV-2-IgG measured 3 months after first vaccine dose. primary endpoint defined as proportion developing antibodies (seroconversion). Secondary endpoints included antibody...
Autoantibody-associated demyelinating diseases of the central nervous system such as myelin oligodendrocyte glycoprotein-antibody associated disease (MOGAD) and aquaporin 4-antibody positive neuromyelitis optica spectrum disorders (AQP4+ NMOSD) are rare but can cause severe disability. In both diseases, neuroinflammation is accompanied by blood cerebrospinal fluid cytokine chemokine signatures, which were shown to be distinct from those observed in patients with multiple sclerosis (MS). this...
The understanding of the pathophysiology multiple sclerosis (MS) has evolved alongside characterization cytokines and chemokines in cerebrospinal fluid (CSF) serum. However, complex interplay pro- anti-inflammatory different body fluids people with MS (pwMS) their association disease progression is still not well understood needs further investigation. Therefore, aim this study was to profile a total 65 cytokines, chemokines, related molecules paired serum CSF samples pwMS at onset.Multiplex...
Tinnitus is a common and often incapacitating hearing disorder marked by the perception of phantom sounds. Susceptibility factors remain largely unknown but GABAB receptor signalling has long been implicated in response to treatment and, putatively, etiology disorder. We hypothesized that variation KCTD12, gene encoding an auxiliary subunit receptors, could help predict risk developing tinnitus. 95 Caucasian outpatients with diagnosis chronic tinnitus were systematically screened for...
Abstract Background and purpose Patients with multiple sclerosis (MS) under certain disease‐modifying therapies (DMT) show a higher risk of infection lower immune response to vaccination. Hence, assessing immunization status prior DMT start and, where necessary, performing vaccinations is recommended. We aimed determine the in MS patients identify factors associated low vaccination rates. Methods who were seen at clinic Medical University Innsbruck throughout period 14 months 2020 2021...
Summary Background As coronavirus disease 2019 caused by severe acute respiratory syndrome 2 evolved only recently, the persistency of anti-viral antibody response remains to be determined. Methods We prospectively followed 29 cases, mean age 44 ± 13.2 years. Except for one participant with a pre-existing diagnosis rheumatoid arthritis, all other participants were previously healthy. determined binding antibodies at 2–10 weeks, 3 months, and 6 months after onset as well neutralizing months....
Introduction Body fluid markers could be helpful to predict the conversion into clinically definite multiple sclerosis (MS) in people with a first demyelinating event of central nervous system (CNS). Consequently, biomarkers such as oligoclonal bands, which are integrated current MS diagnostic criteria, assist early diagnosis.
Abstract Recent reports indicated that myelin oligodendrocyte glycoprotein antibody-associated disease might be a rare complication after severe acute respiratory syndrome coronavirus 2 infection or vaccination. It is unclear whether this an unspecific sequel of vaccination caused by possible immunological cross-reactivity proteins and glycoprotein. The aim study was therefore to elucidate there between spike nucleocapsid explore the relation antibody responses against other coronaviruses....
Due to the demographic development and improved treatment options, role of comorbidities is increasing importance in medical care people with MS (pwMS). A higher risk osteoporosis well known chronic autoimmune diseases, also described MS. While there are several screening guidelines elderly or patients rheumatoid arthritis, no generally accepted recommendations when perform bone mineral testing pwMS under age 65 years. We aimed determine factors develop a score which can be applied daily...
To determine whether there is a correlation between myelin oligodendrocyte glycoprotein (MOG) antibody-associated diseases and varicella zoster virus (VZV) infection. We provide case report performed study to the frequency of MOG antibodies (MOG-IgG) in neurological VZV infections. Patients admitted Medical University Innsbruck from 2008-2020 with diagnosis manifestation infection (n=59) were included this study; patients neuroborreliosis (n=34) served as control group. MOG-IgG was detected...
Abstract The group III metabotropic glutamate receptor subtype 7 (mGlu7) is an important regulator of glutamatergic and GABAergic neurotransmission known to mediate emotionality male social behavior. However, a possible regulatory role in maternal behavior remains unknown date. Adequate expression essential for successful rearing healthy development the young. By understanding genetic neural mechanisms underlying this prosocial behavior, we gain valuable insights into dysregulations. Using...
In most cases, multiple sclerosis (MS) patients reduce physical activity with disease progression and many are found to be vitamin D deficient. The aim of this study was explore correlations between daily in everyday life 25-hydroxyvitamin-D3 (25(OH)D3) serum levels mildly disabled an Expanded Disability Status Scale (EDSS) ≤ 4. We analyzed 25(OH)D3 recorded (activity duration, number steps, distance, energy expenditure) using tracker for 14-days 25 women 15 men. Participants their sunlight...
Abstract The systemic inflammatory response following acute ischaemic stroke remains incompletely understood. We characterised the circulating profile in 173 patients by measuring 65 cytokines and chemokines plasma. Participants were grouped based on their response, determined high-sensitivity C-reactive protein levels phase. compared patients’ profiles with 42 people experiencing spontaneous cervical artery dissection without stroke. Furthermore, variations cytokine among aetiologies...
Abstract Takotsubo syndrome (TTS), commonly perceived as a benign and reversible condition has received attention due to emerging registry data revealing its prognosis be comparable acute coronary (ACS). Following ACS, notable subset of patients develops autonomic dysfunction, whith unfavourable prognostic implications. Periodic repolarization dynamics (PRD) deceleration capacity (DC), derived from ECG signals, are parameters capable quantifying cardiac function. In this study, we aimed...
Abstract Introduction There is a highly complex and clinically important relationship between the cardiac nervous system, called heart-brain axis [1]. Therefore, acute brain damage may lead to alterations in function due changes autonomic system[2,3]. Novel computerised biosignal analysis techniques advanced assessment could provide valuable tool sensitively analyse (CAF). CAF can be characterized by two complementary digital biomarkers, periodic repolariation dynamics (PRD) deceleration...
Rising breakthrough infections with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Omicron BA.4/5 led to the performance of various studies investigating systemic immunity and neutralizing antibodies in sera, but mucosal remains understudied. In this cohort study, humoral immune responses, including immunoglobulin levels presence virus-neutralizing antibodies, 92 vaccinated and/or BA.1/BA.2 convalescent individuals were investigated. Cohorts received two doses ChAdOx1,...