A5012263587- Multiple Sclerosis Research Studies
- Peripheral Neuropathies and Disorders
- Polyomavirus and related diseases
- Systemic Lupus Erythematosus Research
- Olfactory and Sensory Function Studies
- SARS-CoV-2 and COVID-19 Research
- Rheumatoid Arthritis Research and Therapies
- Retinal and Optic Conditions
- Immunotherapy and Immune Responses
- Systemic Sclerosis and Related Diseases
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Cerebrospinal fluid and hydrocephalus
- Reproductive System and Pregnancy
- Full-Duplex Wireless Communications
- Long-Term Effects of COVID-19
- Cerebral Venous Sinus Thrombosis
- Allergic Rhinitis and Sensitization
- Cytokine Signaling Pathways and Interactions
- Herpesvirus Infections and Treatments
- Acute Lymphoblastic Leukemia research
- Hereditary Neurological Disorders
- Traumatic Brain Injury and Neurovascular Disturbances
- Intracranial Aneurysms: Treatment and Complications
- Plant Virus Research Studies
- Ocular Diseases and Behçet’s Syndrome
Innsbruck Medical University
2016-2025
Universität Innsbruck
2016-2025
Medical University of Vienna
2015-2024
University Hospital Innsbruck
2023
Euroimmun Medizinische Labordiagnostika (Germany)
2021
FH Campus Wien
2021
Medical University of Graz
2021
Neurology, Inc
2020
RWTH Aachen University
2017
Tohoku University
2015
Abstract Background Serum autoantibodies against the water channel aquaporin-4 (AQP4) are important diagnostic biomarkers and pathogenic factors for neuromyelitis optica (NMO). However, AQP4-IgG absent in 5-40% of all NMO patients target autoimmune response these is unknown. Since recent studies indicate that responses to myelin oligodendrocyte glycoprotein (MOG) can induce an NMO-like disease experimental animal models, we speculate MOG might be autoantigen seronegative NMO. Although...
To study the humoral immune response directed at myelin oligodendrocyte glycoprotein (MOG)in pediatric patients with isolated and recurrent optic neuritis(ON).Observational prospective case series.Six hospitals in Germany Austria.Thirty-seven 18 years or younger single episodes of ON were recruited from 6 different hospitals.Clinical features, magnetic resonance imaging findings, intrathecal IgG synthesis,and outcome recorded. A live cell–based immunofluorescence assay was used to measure...
Background Neuromyelitis optica (NMO), a severe demyelinating disease, represents itself with optic neuritis and longitudinally extensive transverse myelitis. Serum NMO-IgG autoantibodies (Abs), specific finding in NMO patients, target the water channel protein aquaporin-4 (AQP4), which is expressed as long (M-1) or short (M-23) isoform. Methodology/Principal Findings The aim of this study was to analyze serum samples from patients controls for presence epitope specificity IgG IgM anti-AQP4...
The coronavirus disease 2019 (COVID-19) pandemic challenges neurologists in counseling multiple sclerosis (MS) patients with respect to their risk for and by severe acute respiratory syndrome 2 guiding disease-modifying treatment (DMT). objective was determine the frequency distribution of currently known factors COVID-19 mortality an MS population.Multiple at least one complete case report between January 1, 2015 December 31, from Innsbruck database were cross-sectionally included....
The optic nerve has been recommended as an additional region for demonstrating dissemination in space (DIS) diagnostic criteria multiple sclerosis (MS). aim of this study was to investigate whether adding the determined by optical coherence tomography (OCT) part DIS improves 2017 criteria.From a prospective observational study, we included patients with first demyelinating event who had complete information assess and spectral domain OCT scan obtained within 180 days. Modified (DIS + OCT)...
Cigarette smoking increases the risk for development of multiple sclerosis and modifies clinical course disease. In this study, we determined whether is a factor early conversion to clinically definite after isolated syndrome.We included 129 patients with syndrome, disseminated white-matter lesions on brain magnetic resonance imaging, positive oligoclonal bands in cerebrospinal fluid. The patients' status was obtained at time syndrome.During follow-up 36 months, 75% smokers but only 51%...
Peripapillary retinal nerve fibre layer (pRNFL) thickness is emerging as a marker of axonal degeneration in multiple sclerosis (MS).We aimed to prospectively assess the predictive value pRNFL for progression physical and cognitive disability relapsing-remitting MS (RRMS).In this 3-year longitudinal study on 151 RRMS patients, was measured by spectral-domain optical coherence tomography (OCT). We used proportional hazard models, correcting age, sex, disease duration, Expanded Disability...
<h3>Objectives:</h3> Antibodies to myelin oligodendrocyte glycoprotein (MOG) are detectable in inflammatory demyelinating CNS diseases, and MOG antibody–associated diseases seem have a better prognosis despite occasionally severe presentations. <h3>Methods:</h3> We report the case of 71-year-old patient with acute visual gait disturbance that dramatically worsened bilateral amaurosis, tetraplegia, respiratory insufficiency within few days. <h3>Results:</h3> MRI showed multiple progressive...
Stable disease course may prompt consideration of disease-modifying treatment (DMT) discontinuation in relapsing-remitting multiple sclerosis (RRMS).To investigate the clinical outcome after DMT and to identify predictive factors supporting decision-making.We included 221 RRMS patients, who discontinued ⩾12 months had documented follow-up ⩾2 years discontinuation. Hazard ratios (HRs) with 95% confidence intervals (CIs) regarding relapse disability progression were calculated from Cox...
Multiple sclerosis (MS) has a highly heterogenic course making prediction of long term outcome very difficult.The objective was to evaluate current and identify additional clinical factors that are linked relapsing-remitting MS assessed by disability status 10 years after disease onset.This observational study included 793 patients with MS. Clinical hypothesized influence measured EDSS scores onset were analysed Kaplan-Meier-estimates. Multinomial logistic regression models regarding mild...
Multiple sclerosis (MS) predominantly affects women of child-bearing potential. Pregnancy in MS is still a controversial issue lacking standardized treatment recommendations.To examine the reciprocal effects pregnancy, MS, and disease-modifying (DMT).We analyzed 387 pregnancies 239 with relapsing remitting multiple (RRMS) ⩾1 establishment diagnosis >1 year before conception, ⩾2 years follow-up after delivery. Relapse rates Expanded Disability Status Scale (EDSS) scores were compared during 2...
Background: Macular ganglion cell–inner plexiform layer (mGCIPL) is an emerging biomarker of neuroaxonal degeneration in multiple sclerosis (MS). Objective: We aimed to determine cut-off values mGCIPL thinning for discriminating between progressing and stable patients relapsing (RMS). Methods: This a 3-year prospective longitudinal study on 183 RMS with annual optical coherence tomography. Best possible baseline loss macular (aLmGCIPL) clinically (physical progression or cognitive decline)...
Abstract Background and purpose There is a lack of evidence guiding discontinuation disease‐modifying therapy (DMT) in relapsing multiple sclerosis (RMS). Thus, the objective this study was to generate validate risk score for disease reactivation after DMT RMS. Methods We drew generation validation dataset from two separate prospectively collected observational databases including RMS patients who received interferon‐β or glatiramer acetate ≥12 months, then discontinued ≥6 months had ≥2...
To investigate whether κ-free light chain (κ-FLC) index predicts multiple sclerosis (MS) disease activity independent of demographics, clinical characteristics, and MRI findings.Patients with early MS who had CSF serum sampling at onset were followed for 4 years. At baseline, age, sex, type symptoms, corticosteroid treatment, number T2 hyperintense (T2L) contrast-enhancing T1 lesions (CELs) on determined. During follow-up, the occurrence a second attack start disease-modifying therapy (DMT)...
Background The COVID-19 pandemic challenges neurologists in counselling patients with multiple sclerosis (pwMS) regarding their risk by SARS-CoV-2 and guiding disease-modifying treatment (DMT). Objective To characterize the prevalence outcome of pwMS specifically associated different DMT a nationwide population-based study. Methods We included aged ≥18 years confirmed diagnosis MS established between January 1, 2020 December 31, 2020. classified course as either mild, severe or fatal. Impact...
Long-term outcome after COVID-19 in patients with multiple sclerosis (pwMS) is scarcely studied and controlled data are lacking.
Background and purpose Peripapillary retinal nerve fibre layer (pRNFL) thickness is a strong candidate as biomarker of axonal degeneration in multiple sclerosis (MS). The aim was to determine cut‐off value pRNFL thinning rates relapsing–remitting MS (RRMS) discriminate between stable progressing patients. Methods In this 3‐year prospective longitudinal study on 141 RRMS patients, annual (aLpRNFL) were determined by individual linear regression models. best possible discriminating clinically...
PIRA (progression independent of relapse) has emerged as a term to quantify the proportion disability worsening due non-inflammatory neurodegenerative processes in multiple sclerosis (MS).To determine impact on retinal thinning, biomarker neuroaxonal degeneration MS, comparison traditional and relapse.In 4-year, prospective observational study including 171 relapsing MS (RMS) patients, thinning was determined by annual spectral-domain optical coherence tomography measuring macular...
Knowledge on immunity after SARS-CoV-2 infection in patients with multiple sclerosis (pwMS) and the impact of disease-modifying treatment (DMT) is limited.To evaluate degree, duration potential predictors specific humoral immune response pwMS prior COVID-19.Anti-SARS-CoV-2 antibody testing was performed PCR-confirmed diagnosis symptomatic COVID-19 from a nation-wide registry. Predictors seropositivity were identified by multivariate regression models.In 125 (mean age = 42.4 years (SD 12.3...
Inter-individual courses of multiple sclerosis (MS) are extremely variable. The objective this study was to investigate whether κ-free light chain (κ-FLC) index and serum neurofilament (sNfL) have an additive predictive value for MS disease activity.Patients with early who had cerebrospinal fluid (CSF) sampling at onset were followed four years. At baseline, age, sex, duration, number T2-hyperintense (T2L), contrast-enhancing T1 lesions (CEL) on MRI determined. During follow-up, the...