A5047042432- Glaucoma and retinal disorders
- Retinal Diseases and Treatments
- Retinal Imaging and Analysis
- Cerebral Venous Sinus Thrombosis
- Retinal and Optic Conditions
- Ocular Diseases and Behçet’s Syndrome
- Multiple Sclerosis Research Studies
- Neurosurgical Procedures and Complications
- Antioxidant Activity and Oxidative Stress
- Systemic Lupus Erythematosus Research
- Drug-Induced Ocular Toxicity
- Blood Pressure and Hypertension Studies
- Mitochondrial Function and Pathology
- Neurological Disorders and Treatments
- Cardiovascular Health and Disease Prevention
- Intracerebral and Subarachnoid Hemorrhage Research
- Ophthalmology and Eye Disorders
- Retinal Development and Disorders
- Acute Ischemic Stroke Management
- Peripheral Neuropathies and Disorders
- Optical Coherence Tomography Applications
- Optical Imaging and Spectroscopy Techniques
- Traumatic Brain Injury and Neurovascular Disturbances
- Cerebrovascular and Carotid Artery Diseases
- Migraine and Headache Studies
Medical University of Vienna
2015-2025
Vienna General Hospital
2022
Universitätsklinik für Augenheilkunde
2021
Women's General Hospital
2015
Ophthalmology Associates (United States)
2010-2011
Institute for Pharmaeconomic Research
2008-2010
Leber hereditary optic neuropathy (LHON) is a mitochondrial disease leading to rapid and severe bilateral vision loss. Idebenone has been shown be effective in stabilizing restoring patients treated within 1 year of onset The open-label, international, multicenter, natural history-controlled LEROS study (ClinicalTrials.gov NCT02774005) assesses the efficacy safety idebenone treatment (900 mg/day) with LHON up 5 years after symptom (N = 199) over period 24 months, compared an external history...
There is evidence from several large-scale clinical trials that reduced intake of lutein, a major component the macular pigment, risk factor for development AMD. In present study (LISA; Lutein Intervention Study Austria) it was hypothesized lutein supplementation increases pigment optical density (MPOD). addition, an investigation conducted into whether improves visual acuity (VA) and function (mean differential light threshold; MDLT), as assessed with microperimetry.One hundred twenty-six...
Abstract Background In idiopathic intracranial hypertension (IIH), sustained weight loss is the main pillar in modifying disease course, whereby glucagon-like peptide-1 receptor agonists (GLP-1-RAs) could present an attractive treatment option. Methods this open-label, single-center, case–control pilot study, patients with IIH (pwIIH) and a body mass index (BMI) of ≥ 30 kg/m 2 were offered to receive GLP-1-RA (semaglutide, liraglutide) addition usual care management (UCWM). Patients electing...
The optic nerve has been recommended as an additional region for demonstrating dissemination in space (DIS) diagnostic criteria multiple sclerosis (MS). aim of this study was to investigate whether adding the determined by optical coherence tomography (OCT) part DIS improves 2017 criteria.From a prospective observational study, we included patients with first demyelinating event who had complete information assess and spectral domain OCT scan obtained within 180 days. Modified (DIS + OCT)...
A variety of studies have shown that flicker-induced vasodilatation is reduced in patients with diabetes. It is, however, unclear whether neural activity or abnormal neurovascular coupling the reason for this phenomenon. In present study, we hypothesized retinal dysfunction precedes early type 1 diabetes.In 50 diabetes without retinopathy and healthy age- sex-matched control subjects were included. The vascular response to flicker stimulation was measured using dynamic Retinal Vessel...
To investigate whether intravitreal ranibizumab (0.05 mL) treatment affects retinal vessel diameters and retrobulbar blood velocities in patients with acute branch vein occlusion (BRVO).Thirty clinically significant macular edema secondary to BRVO were included. The duration of the study was three months. Patients studied before one week, month, two months, months after first injection. Depending on clinical requirements, up injections administered. Retinal measured using a analyzer. Flow...
OBJECTIVE Flicker-induced vasodilatation is reduced in patients with vascular-related diseases, which has at least partially been attributed to endothelial dysfunction of retinal vessels. Currently, the standard method assess function vivo flow-mediated (FMD). Thus, present study was performed investigate whether a correlation exists between flicker-induced and FMD known healthy subjects. RESEARCH DESIGN AND METHODS In study, 20 type 1 diabetes, 40 systemic hypertension (systolic blood...
Various studies have shown that retinal vessels in patients with diabetes mellitus a reduced capacity to adapt changes perfusion pressure and stimulation flickering light. Structural functional could lead general reduction of vasodilator and/or vasoconstrictor capacity. To gain more insight into this topic, we compared the response vessel diameters systemic glyceryl trinitrate (GTN) diffuse luminance flicker healthy control subjects.Twenty type 1 featuring no or mild nonproliferative...
Abstract Objective To assess the prognostic impact of migraine headache in idiopathic intracranial hypertension (IIH). Background Migraine is common IIH, but it unclear whether has relevance. Methods We investigated patients with IIH from Vienna‐IIH‐database and differentiated (IIH‐MIG) non‐migraine (IIH‐nonMIG) without (IIH‐noHA). Using multivariable models, we analyzed IIH‐MIG on visual outcomes 12 months after diagnosis. Results Among 97 (89% female, mean [SD] age 32.9 [11.1] years,...
Summary Background Idiopathic intracranial hypertension (IIH) is becoming increasingly more prevalent bearing the risk of visual impairment and affecting quality life. Clinical presentation outcome are heterogeneous. Large, well-characterized cohorts scarce. Objective To characterize clinical spectrum, diagnostic findings, therapeutic management, IIH. Methods We identified patients with IIH according to modified Friedman criteria treated at our center between 2014 2021. The Vienna database...
The magnetic resonance imaging (MRI) criteria currently used to diagnose idiopathic intracranial hypertension (IIH) are based on expert opinion and have limited accuracy. Additional neuroimaging signs been proposed with contradictory results; thus, prospective evidence is needed improve diagnostic
To compare total retinal blood flow in diabetic patients with no or mild nonproliferative retinopathy and healthy control subjects to investigate whether there is a difference between before morning insulin under normoglycemic conditions using glucose clamp.Twenty type 1 diabetes were included this open parallel-group study, 20 age- sex-matched as subjects. Retinal was assessed by combining velocity measurements laser Doppler velocimetry diameter commercially available dynamic vessel...
Purpose.: A number of previous studies have shown that blood velocities in retrobulbar arteries, as assessed with color Doppler imaging (CDI), are reduced primary open angle glaucoma (POAG) patients, indicative flow to the eye. In present study, authors hypothesized patients POAG show an abnormal association between CDI and pressure, vascular dysregulation. Methods.: total 252 198 healthy age-matched control subjects were included. Mean velocity (MFV) ophthalmic artery (OA), posterior...
The aim of the project was to identify risk factors associated with visual progression and treatment indications in pediatric patients neurofibromatosis type 1 optic pathway glioma (NF1-OPG).A multidisciplinary expert group consisting ophthalmologists, neuro-oncologists, specialists, neuro-radiologists involved therapy trials assembled a cohort children NF1-OPG from 6 European countries complete clinical, imaging, outcome datasets. Using methods developed during consensus workshop, imaging...
Management of idiopathic intracranial hypertension (IIH) is complex requiring multiple specialized disciplines. In practice, this creates considerable organizational and communicational challenges for healthcare professionals patients. Thus, an interdisciplinary integrated outpatient clinic IIH (comprising neurology, neuroophthalmology, neuroradiology, neurosurgery endocrinology) was established with central coordination a one-stop concept. Here, the aim to evaluate effects concept on...
Introduction: The 2024 McDonald criteria for diagnosing multiple sclerosis (MS) include optic nerve involvement as a fifth region establishing dissemination in space. Optic neuritis (ON) can be detected through optical coherence tomography (OCT) using an inter-eye absolute or percentage difference (IEAD, IEPD) ganglion cell-inner plexiform layer (GCIPL) thickness. Objective: To compare the diagnostic accuracy of GCIPL IEAD/IEPD with GCL and IPL alone identifying history ON. Methods: This...
To investigate the fluctuations of ocular blood flow parameters over 13 h in patients with primary open-angle glaucoma (POAG) and healthy eyes, to relate these variations intraocular pressure (IOP) mean perfusion (OPP).15 POAG 15 control subjects were included. Measurements systemic (SBP), fundus pulsation amplitude (FPA), choroidal (CHBF), optic nerve head (ONHBF) IOP performed at 08:00, 12:00, 17:00 21:00. OPP was calculated from SBP. The coefficient variation (CV) for all individual...
Abstract. Purpose: Previous studies have reported an age‐dependent decline of macular pigment optical density (MPOD) as well a relative lack MPOD in age‐related degeneration (AMD). Results are, however, strongly dependent on the technique used. In this study, we investigated age dependence using spectral fundus reflectance. addition, hypothesized that patients with AMD reduced compared to healthy controls. Methods: A total 85 subjects and 96 were included study. The control showed wide range...
Progressive impairment and degeneration of retinal ganglion cells (RGC) nerve fibers in Leber’s hereditary optic neuropathy (LHON) usually cause permanent visual loss. Idebenone is currently the only approved treatment. However, its therapeutic potential different stages LHON has not been definitely clarified. We aimed to investigate changes function correlations with structure acute chronic patients after treatment idebenone. Twenty-three genetically confirmed were followed during using...
This study was undertaken to investigate baseline peripapillary retinal nerve fiber layer (pRNFL) and macular ganglion cell inner plexiform (GCIPL) thickness for prediction of disability accumulation in early relapsing multiple sclerosis (RMS).From a prospective observational study, we included patients with newly diagnosed RMS obtained spectral-domain optical coherence tomography scan within 90 days after diagnosis. Impact pRNFL GCIPL (confirmed Expanded Disability Status Scale [EDSS] score...
In Brief Purpose: To evaluate changes in the distribution and morphology of intraretinal microexudates hard exudates (HEs) during intravitreal anti-vascular endothelial growth factor therapy patients with persistent diabetic macular edema. Methods: Twenty-four edema after photocoagulation were investigated this prospective cohort study. Each eye was assigned to a loading dose three treatments at monthly intervals. Additional single performed if persisted or recurred. Intraretinal analyzed...
Leber's hereditary optic neuropathy (LHON) is a mitochondrial disease characterized by subacute and progressive impairment subsequent degeneration of retinal ganglion cells (RGCs). In most cases, it results in nerve atrophy permanently reduced visual acuity (VA). Idebenone has recently been approved Europe for treating LHON. However, published clinical data only focused on efficacy patients within the first years after onset. The present study to evaluate possible effects idebenone treatment...