A5044975485- Cerebral Venous Sinus Thrombosis
- Glaucoma and retinal disorders
- Neurosurgical Procedures and Complications
- Pituitary Gland Disorders and Treatments
- Ocular Diseases and Behçet’s Syndrome
- Cerebrospinal fluid and hydrocephalus
- Neurological Complications and Syndromes
- Retinal and Optic Conditions
- Natural product bioactivities and synthesis
- Flavonoids in Medical Research
- Dementia and Cognitive Impairment Research
- Neuroendocrine Tumor Research Advances
- Blood Coagulation and Thrombosis Mechanisms
- Migraine and Headache Studies
- Cardiovascular Disease and Adiposity
- Traumatic Brain Injury and Neurovascular Disturbances
- Neuroscience of respiration and sleep
- Neonatal and fetal brain pathology
- Pancreatic and Hepatic Oncology Research
- Ophthalmology and Eye Disorders
- Rheumatoid Arthritis Research and Therapies
- Renal Transplantation Outcomes and Treatments
- Barrier Structure and Function Studies
- Cardiovascular Health and Disease Prevention
- Chronic Lymphocytic Leukemia Research
Rigshospitalet
2017-2024
University of Copenhagen
2016-2024
Glostrup Hospital
2017-2022
Odense University Hospital
2022
University of Southern Denmark
2022
Basque Center for Applied Mathematics
2017
VA Center for Clinical Management Research
2012
Regionshospitalet Viborg
1987
GLP-1R agonists show promise as a therapeutic agent to lower intracranial pressure in rodents.
Based on expert opinion, abducens nerve palsy and a neuroimaging criterion (≥3 signs suggestive of elevated intracranial pressure) were added to the diagnostic criteria for idiopathic hypertension. Our objective was validate this.This prospective study included patients with new-onset hypertension standardized work-up: interview, neuro-ophthalmological exam, lumbar puncture, neuroimaging. Neuroimaging evaluated by blinded neuroradiologist.We 157 classified as (56.7%), probable (1.9%),...
Idiopathic intracranial hypertension (IIH) is a neurometabolic disease with an increasing incidence. The pathophysiology unknown, but improvement of diagnosis and management requires discovery novel biomarkers. Our objective was to identify such candidate biomarkers in IIH, secondarily, test for associations between identified metabolites severity.
The magnetic resonance imaging (MRI) criteria currently used to diagnose idiopathic intracranial hypertension (IIH) are based on expert opinion and have limited accuracy. Additional neuroimaging signs been proposed with contradictory results; thus, prospective evidence is needed improve diagnostic
Background Idiopathic intracranial hypertension (IIH) occurs more frequently in obese females of childbearing age. A link between eating disorders and poor outcome has been suggested but remains unproven. Methods This prospective field study at two tertiary headache centers included patients with clinically suspected IIH after standardized diagnostic work-up. Eating were evaluated using validated questionnaires (EDQs). Primary was the impact on severity outcome, secondary prevalence type...
We have studied a family in which 14 persons among 73 are or been suffering from presenile dementia. Post mortem examination showed atrophy but no sign of any known demential syndrome. Cerebral blood flow measured the late stage disease was low, with characteristic pattern distribution. In one patient initial disease, cerebral unexpectedly increased. The patients dementia this did not reveal pathological signs syndrome and CBF-changes earlier reported. Moreover, contrary to widely held views...
Psychiatric disease is a frequent comorbidity in idiopathic intracranial hypertension (IIH) and has been associated with poor subjective outcome. No prospective studies have investigated psychiatric comorbidities new-onset IIH. Our primary aim was to investigate severity IIH depending on comorbid disease. Important secondary outcomes were after 6 months prevalence of diseases IIH.This prospective, observational cohort study consecutively included patients clinically suspected, from 2...
Elevated intracranial pressure (ICP) is observed in many brain disorders. Obesity has been linked to ICP pathogenesis disorders such as idiopathic (IIH). We investigated the effect of diet induced obesity (DIO) on and clinically relevant sequelae. Rats were fed either a control or high fat diet. Following weight gain long term ICP, headache behavior, body composition retinal outcome examined. Post-hoc analysis histology molecular choroid plexus trigeminal ganglion (TG) performed. DIO rats...
Our objective was to assess optic nerve sheath diameter (a marker of elevated intracranial pressure) and disc elevation papilledema) in pseudotumor cerebri syndrome using transorbital sonography.The study a prospective case-control study. We included patients with new-onset matched healthy controls. All had fundoscopy, lumbar puncture opening pressure sonography. Sonography assessed by blinded observer.We evaluated 45 23 cases. recruited 35 Optic larger compared controls (6.3 ± 0.9 mm versus...
Loss of vision is a feared consequence idiopathic intracranial hypertension (IIH). Optic nerve sheath fenestration (ONSF) may be an effective surgical approach to protect visual function in medically refractory IIH. In this study, we evaluate the impact unilateral superomedial transconjunctival ONSF on bilateral outcome using comprehensive follow-up program. A retrospective chart review IIH patients who underwent between January 2016 and March 2021 was conducted. Patients fulfilling revised...
Retinal vessel dynamics analysis has proven to be a viable, non-invasive surrogate marker for increased intracranial pressure. We aimed test this method in patients with suspected idiopathic hypertension.Patients hypertension were prospectively enrolled hand-held fundus-videography during diagnostic lumbar puncture. After extracting optic disc images, peripapillary arteriole-to-venule-ratios measured using machine-learning algorithms manual identification control. A general linear model was...
Graphical representation of the mediatory relationship between medication and sleep quality, headache
Background Damage of the optic nerve is major complication idiopathic intracranial hypertension. A biomarker indicative for damage would help identifying high-risk patients requiring surgical procedures. Here, we studied potential cerebrospinal fluid neurofilament to predict hypertension-induced damage. Methods In two centers, serum and 61 with clinically suspected hypertension were prospectively collected. Neurofilament concentrations measured related ophthalmological assessment. Results...
Abstract Background The kaolin induced obstructive hydrocephalus (OHC) model is well known for its ability to increase intracranial pressure (ICP) in experimental animals. Papilledema (PE) which a predominant hallmark of elevated ICP the clinic has not yet been studied this using high-resolution digital fundus microscopy. Further, long-term effect on and optic nerve head changes have fully demonstrated. In study we aimed monitor epidural after induction OHC examine disc. addition, validated...
Idiopathic intracranial hypertension is a secondary headache disorder potentially causing visual loss. Neurofilament light chain candidate, prognostic biomarker, but further studies of neuronal biomarkers are needed. Our objective was to investigate neurofilament in cerebrospinal fluid (cNfL) and plasma (pNfL), amyloid-beta 42 (Aβ-42), total-tau phosphorylated-tau new-onset idiopathic hypertension.
Current therapies for reducing raised intracranial pressure (ICP) in conditions such as idiopathic hypertension (IIH) have limited efficacy and tolerability; therefore there is an urgent need to develop novel therapies. Glucagon-like peptide-1 receptor (GLP-1R) agonists are used therapeutically treat diabetes promote weight loss but also been shown affect fluid homeostasis the kidney. The GLP-1R present choroid plexus, we investigated whether Exendin-4, a agonist, able modulate cerebrospinal...
Searchable abstracts of presentations at key conferences in endocrinology ISSN 1470-3947 (print) | 1479-6848 (online)
Abstract Elevated intracranial pressure (ICP) is observed in many brain disorders. Obesity has been linked to ICP pathogenesis disorders such as idiopathic (IIH). We investigated the effect of diet induced obesity (DIO) on and clinically relevant sequelae. Rats were fed either a control or high fat diet. Following weight gain long term ICP, headache behavior, body composition retinal outcome examined. Post-hoc analysis histology molecular choroid plexus trigeminal ganglion (TG) performed....
Searchable abstracts of presentations at key conferences in endocrinology ISSN 1470-3947 (print) | 1479-6848 (online)