A5072218702- Cerebral Venous Sinus Thrombosis
- Pituitary Gland Disorders and Treatments
- Glaucoma and retinal disorders
- Biochemical effects in animals
- Neurosurgical Procedures and Complications
- Regulation of Appetite and Obesity
- Adipose Tissue and Metabolism
- Migraine and Headache Studies
- Traumatic Brain Injury and Neurovascular Disturbances
- Sympathectomy and Hyperhidrosis Treatments
- Fibroblast Growth Factor Research
- Trigeminal Neuralgia and Treatments
- Cardiovascular Disease and Adiposity
- Coffee research and impacts
- Cerebrospinal fluid and hydrocephalus
- Cardiovascular Health and Disease Prevention
- Metabolism, Diabetes, and Cancer
- Diet and metabolism studies
- Pancreatic function and diabetes
Glostrup Hospital
2021-2023
University of Copenhagen
2020-2023
Rigshospitalet
2021-2023
Acute administration of the main protein component high-density lipoprotein, apolipoprotein A-I (ApoA-1), improves glucose uptake in skeletal muscle. The molecular mechanisms mediating this are not known, but muscle cell cultures, ApoA-1 failed to increase when infected with a dominant-negative AMP-activated kinase (AMPK) virus. We therefore investigated whether AMPK is necessary for ApoA-1-stimulated intact heart and vivo.
Caffeine, a non-selective adenosine receptor (AR) antagonist, is the most consumed psychostimulant in world. Caffeine has been suggested to regulate cerebrospinal fluid secretion and known both alleviate trigger headache; however, its effect on regulation of intracranial pressure (ICP) not known. Therefore, we aimed investigate effects caffeine ICP nociceptive responses.
Elevated intracranial pressure (ICP) is observed in many brain disorders. Obesity has been linked to ICP pathogenesis disorders such as idiopathic (IIH). We investigated the effect of diet induced obesity (DIO) on and clinically relevant sequelae. Rats were fed either a control or high fat diet. Following weight gain long term ICP, headache behavior, body composition retinal outcome examined. Post-hoc analysis histology molecular choroid plexus trigeminal ganglion (TG) performed. DIO rats...
Diseases of raised intracranial pressure (ICP) cause severe morbidity and mortality. Multiple drugs are utilised to lower ICP including acetazolamide topiramate. However, the evidence for their use is unclear. We aimed assess modulatory effects molecular at choroid plexus (CP)
Female sex is a known risk factor of brain disorders with raised intracranial pressure (ICP) and hormones have been suggested to alter cerebrospinal fluid (CSF) dynamics, thus impairing ICP regulation in CSF such as idiopathic hypertension (IIH). The choroid plexus (CP) the tissue producing it has hypothesized that altered hormonal composition could affect activity transporters involved secretion, affecting ICP. Therefore, we aimed investigate if expression various secretion at CP were...
Abstract Background Glucocorticoids (GCs) are widely prescribed for a variety of inflammatory diseases, but they also used to treat raised intracranial pressure (ICP) caused by trauma or oedema. However, it is unclear if GCs independently modulate ICP and involved in normal regulation. In this study, we aimed assess the modulatory effects their molecular consequences on choroid plexus (CP). Methods Adult female rats were implanted with telemetric probes physiological, continuous recordings...
Abstract Elevated intracranial pressure (ICP) is observed in many brain disorders. Obesity has been linked to ICP pathogenesis disorders such as idiopathic (IIH). We investigated the effect of diet induced obesity (DIO) on and clinically relevant sequelae. Rats were fed either a control or high fat diet. Following weight gain long term ICP, headache behavior, body composition retinal outcome examined. Post-hoc analysis histology molecular choroid plexus trigeminal ganglion (TG) performed....
Searchable abstracts of presentations at key conferences in endocrinology ISSN 1470-3947 (print) | 1479-6848 (online)