A5081639324- Amyotrophic Lateral Sclerosis Research
- Neurogenetic and Muscular Disorders Research
- Knee injuries and reconstruction techniques
- Nerve injury and regeneration
- Muscle activation and electromyography studies
- Rheumatoid Arthritis Research and Therapies
- Sports injuries and prevention
- Prion Diseases and Protein Misfolding
- Cerebrospinal fluid and hydrocephalus
- Botulinum Toxin and Related Neurological Disorders
- Foot and Ankle Surgery
- Ion channel regulation and function
- Neuroscience and Neural Engineering
- Pain Mechanisms and Treatments
- Traumatic Brain Injury and Neurovascular Disturbances
- Parkinson's Disease Mechanisms and Treatments
- Lower Extremity Biomechanics and Pathologies
- Neurological disorders and treatments
- Musculoskeletal synovial abnormalities and treatments
- Orthopedic Surgery and Rehabilitation
- Metastasis and carcinoma case studies
- Ion Transport and Channel Regulation
- Sexual Differentiation and Disorders
- Actinomycetales infections and treatment
- Central Venous Catheters and Hemodialysis
University of Copenhagen
1999-2025
North Denmark Region
2019
Rigshospitalet
1997-2016
Center for Rheumatology
2016
Region Zealand
2015
Capital University
2015
Glostrup Hospital
1988-2014
Gentofte Hospital
1990-2002
In a suburban area of Copenhagen with approximately 620,000 inhabitants, all the openly operated on meniscal lesions knee joint between 1982 and 1984 inclusive were reviewed. The mean annual incidence per 10,000 inhabitants was 9.0 in males 4.2 females. highest incidences seen 3rd, 4th, 5th decades life. A higher frequency trauma related to onset symptoms found among (77 percent) than females (64 percent). bucket-handle lesion most frequent type (35 percent), whereas peripheral detachment...
Although in vitro recordings using neonatal preparations from mouse models of amyotrophic lateral sclerosis (ALS) suggest increased motoneurone excitability, vivo adult ALS have been conflicting. In G93A SOD1 models, spinal motoneurones previously shown to deficits repetitive firing, contrast the G127X model. Our intracellular barbiturate-anaesthetized male mice reveal that incidence failure fire with current injection was equally low control and (∼2%). We show repetitively can be a...
A hyperexcitability of the motor system is consistently observed in Amyotrophic Lateral Sclerosis (ALS) and has been implicated disease pathogenesis. What drives this vast majority patients unknown. This important to know as existing treatments simply reduce all neuronal excitability fail distinguish between pathological changes homeostatic changes. Understanding what initial could therefore provide better treatments. One challenge that represent a heterogeneous population cases are...
Abstract Cerebrospinal fluid (CSF) dynamics hold implications for neurological health. Despite its importance, accurate quantification of the CSF secretion rate remains a challenge due to methodological controversies and influence anesthesia. A novel technique is established determine in awake freely moving rats, quantified with three different methodologies. The higher rats than anesthetized latter demonstrating no requirement mechanical ventilation optimal quantification. ≈10‐fold lower...
Cerebrospinal fluid (CSF) is produced and absorbed at a balanced rate to maintain constant intracranial pressure (ICP). The CSF dynamics are, however, disturbed in several pathological conditions, leading elevated ICP, which may have fatal outcomes if left untreated. Treatment options for these conditions are limited invasive neurosurgery, novel pharmacological approaches manage ICP pathology sought. Here, we aimed demonstrate the potential of glucagon-like peptide-1 receptor (GLP-1R) as...
Trefoil factors (TFFs) 1, 2, and 3 are expressed in mucosal epithelia. TFFs particular abundant the intestine which they play a crucial role maintenance restitution of epithelium. Because pancreas developmentally arises from primitive foregut, we explored expression man rat. Immunocytochemical staining adult human showed TFF3 immunoreactivity pancreatic islets some duct cells, whereas weak TFF1 no TFF2 were detected. In localized to most insulin glucagon polypeptide-producing cells. was...
Abstract Intramuscular injections of botulinum toxin block pre-synaptic cholinergic release at neuromuscular junctions producing a temporary paralysis affected motor units. There is increasing evidence, however, that the effects are not restricted to periphery and can alter central excitability motoneurones spinal level. This includes increases in input resistance, decreases rheobase currents for action potentials prolongations post-spike after-hyperpolarization. The aim our experiments was...
Botulinum toxin (Btx) is used in children with cerebral palsy and other neurological patients to diminish spasticity reduce the risk of development contractures. We investigated changes central gain stretch reflex circuitry response Btx injection triceps surae muscle rats. Experiments were performed 21 Eight rats a control group, 13 injected 6 IU left muscle. Two weeks after injection, larger monosynaptic reflexes (MSR) recorded from (injected) than right (noninjected) L4 + L5 ventral roots...
Abstract We investigated the influence of electrical stimulation posterior cruciate ligament (PCL) on motoneuron pool thigh and calf muscle during gait. The study group comprised eight young men without any history injury to knee joints. Multistranded teflon‐insulated stainless steel wires were inserted into PCL guided by sonography in four subjects also fat pad knee. was electrically stimulated gait a treadmill at heel strike 100 ms after strike. Electromyographic signals recorded with...
In the motor system, force gradation is achieved by recruitment of motoneurons and rate modulation their firing frequency. Classical experiments investigating relationship between injected current to soma during intracellular recording frequency (the I–f relation) in cat spinal identified two clear ranges: a primary range secondary range. Recent work mice, however, has an additional proposed be exclusive rodents, subprimary (SPR), due presence mixed mode oscillations membrane potential....
Neuromodulators, such as serotonin (5-hydroxytryptamine, 5-HT) and noradrenalin, play an essential role in regulating the motor sensory functions spinal cord. We have previously shown that rat cord activity of aromatic L-amino acid decarboxylase (AADC) cells to produce 5-HT from its precursor (5-hydroxytryptophan, 5-HTP) is dramatically increased following complete transection. In this study, we investigated whether a partial loss innervation could similarly increase AADC activity. Adult...
We investigated the influence of electrical stimulation posterior cruciate ligament (PCL) on motoneuron pool thigh muscle during voluntary static and dynamic contraction. The study group comprised nine young men with no history injury to knee joints. Multistranded Teflon-insulated stainless-steel wires were inserted into PCL guided by ultrasound. In three subjects also fat pad knee. was electrically stimulated static, concentric, or eccentric contraction a constant load 20% maximal either...
Fifteen patients with 17 patellectomies for chondromalacia were evaluated after an average of 5.5 years. The age was 38 No knees rated as excellent, whereas 5 good, 9 fair, and 3 poor. However, 10 patients, including both bilateral patellectomies, satisfied the results.
Abstract An altered neuronal excitability of spinal motoneurones has consistently been implicated in Amyotrophic Lateral Sclerosis (ALS) leading to several investigations synaptic input these motoneurones. One such that repeatedly shown be affected is a population large cholinergic synapses terminating mainly on the soma referred as C-boutons. Most research during disease progression used transgenic Superoxide Dismutase 1 (SOD1) mouse models which have not only produced conflicting findings,...
Abstract A hyperexcitability of the motor system is consistently observed in Amyotrophic Lateral Sclerosis (ALS) and has been implicated disease pathogenesis. What drives this vast majority patients unknown. This important to know as existing treatments simply reduce all neuronal excitability fail distinguish between pathological changes homeostatic changes. Understanding what initial could therefore provide better treatments. One challenge that represent a heterogeneous population cases are...
Disturbances in the brain fluid balance can lead to life-threatening elevation intracranial pressure (ICP), which represents a vast clinical challenge. Targeted and efficient pharmaceutical therapy of elevated ICP is not currently available, as molecular mechanisms governing cerebrospinal (CSF) secretion are largely unresolved. To resolve quantitative contribution key choroid plexus transport proteins, this study employs mice with genetic knockout and/or viral plexus-specific knockdown...
Malignant melanoma (MM) rarely involves the esophagus. The outlook is dismal unless lesional tissue limited to esophageal wall. Hence, staging prior extensive surgical intervention desirable.A 54-year-old male presented with fatigue and melena. A diagnosis of MM primary in esophagus was rendered on a biopsy an polyp. stage, determined by endoscopic ultrasonography-guided fine needle aspiration biopsy, advanced. On basis this information, it decided spare patient mutilating surgery.This...
Abstract In vitro studies from transgenic Amyotrophic Lateral Sclerosis models have suggested an increased excitability of spinal motoneurones. However, in vivo intracellular recordings adult ALS mice produced conflicting findings. Previous publications using barbiturate anaesthetised G93A SOD1 that some motoneurones are hypo-excitable, defined by deficits repetitive firing. Our own previous G127X different anaesthesia, however, showed no firing deficits, and persistent inward currents at...