A5009693194- Mitochondrial Function and Pathology
- Glaucoma and retinal disorders
- ATP Synthase and ATPases Research
- Venous Thromboembolism Diagnosis and Management
- Intraocular Surgery and Lenses
- Retinal and Optic Conditions
- Corneal surgery and disorders
- Traumatic Brain Injury and Neurovascular Disturbances
- Intraoperative Neuromonitoring and Anesthetic Effects
- Asthma and respiratory diseases
- Multiple Sclerosis Research Studies
- IL-33, ST2, and ILC Pathways
- Peripheral Neuropathies and Disorders
- Retinal Development and Disorders
- Radiology practices and education
- Prostate Cancer Treatment and Research
- Metabolism and Genetic Disorders
- Hemodynamic Monitoring and Therapy
- Prostate Cancer Diagnosis and Treatment
- Ocular Diseases and Behçet’s Syndrome
- Retinal and Macular Surgery
- Multisensory perception and integration
- Ophthalmology and Visual Health Research
- Genetic and rare skin diseases.
- Cerebral Venous Sinus Thrombosis
University College London
2018-2025
King's College Hospital NHS Foundation Trust
2024
Moorfields Eye Hospital
2018-2024
Moorfields Eye Hospital NHS Foundation Trust
2023-2024
Institute of Ophthalmology
2024
Providence College
2023
GlaxoSmithKline (United States)
2023
ZOLL Medical Corporation (United States)
2023
Boston University
2020-2021
Massachusetts General Hospital
2021
Leber hereditary optic neuropathy (LHON) is a mitochondrial disease leading to rapid and severe bilateral vision loss. Idebenone has been shown be effective in stabilizing restoring patients treated within 1 year of onset The open-label, international, multicenter, natural history-controlled LEROS study (ClinicalTrials.gov NCT02774005) assesses the efficacy safety idebenone treatment (900 mg/day) with LHON up 5 years after symptom (N = 199) over period 24 months, compared an external history...
Diaphyseal fractures of the distal third radius that are associated with disruption radio-ulnar joint accounted for eighty-four (6.8 per cent) 1236 in forearm were treated during a five-year period at Los Angeles County-University Southern California Medical Center. Thirty-six closed Galeazzi fractures, twenty-eight male and eight female patients, followed 1.5 to seven years after treatment using standard AO-compression plates four holes. Complications included injuries sensory or dorsal...
Five hundred and thirty-one closed biopsies have been done in our general hospital since 1967. Four eighty-four were for lesions of bone forty-seven soft-tissue lesions. More than half the infections or nonspecifically reactive. The procedure was under local anesthesia 73 per cent roentgenographic image-intensifier control generally required. Craig needle used cancellous near vital structures; Michele trephine, cortical sclerotic at a distance from special soft tissue. Closed biopsy provided...
Dominant optic atrophy (DOA, OMIM 165500) is the most common inherited neuropathy (1), with prevalence estimates of 1:12,000 in Denmark (2) and 1:25,000 North East England (3). Inherited neuropathies carry a poor visual prognosis have significant detrimental impact on quality life, high rates psychological distress great societal costs (4–7). DOA was first described British family by Batten 19th century (8) confirmed larger studies German families Jaeger (9) Danish Kjer (10). These...
The use of gauge earrings causes earlobe defects and, at times, significant contour distortion. Simple closure leads to inadequate results in most cases. We describe a stratified approach assessing the deformity as well specific reconstructive techniques tailored each type restore normal size and contour, which, our knowledge, has not been discussed literature thus far.This case series reviewed last 20 patients who requested reconstruction with least 1 year follow-up. Earlobe can be...
To establish the level of confidence amongst UK ophthalmology specialist registrars (residents) in managing posterior capsule rupture (PCR) during cataract surgery.An online nine-item questionnaire was distributed to all registrars, recruited nationwide via regional representatives. Data collected included stage training, number completed operations, cumulative PCR rate, PCRs independently managed, understanding vitrectomy settings and fluidic parameters access simulation. Respondents...
Abstract Autosomal dominant optic atrophy (DOA) is an inherited neuropathy that results in progressive, bilateral visual acuity loss and field defects. OPA1 the causative gene around 60% of cases DOA. The majority patients have a pure ocular phenotype, but 20% extra-ocular features (DOA +). We report on patient with DOA + manifesting as atrophy, spastic paraparesis, urinary incontinence white matter changes central nervous system associated novel heterozygous splice variant NM_015560.2(...
Communicated by Nigel Boston
A 46-year-old woman presented with severe upper abdominal pain and vomiting 12 h post-endoscopic retrograde cholangiopancreatography (ERCP) sphincterotomy for choledocholithiasis. The patient also described a sensation of ‘crackling in the neck’ on head rotation. On examination, was stable afebrile, had right hypochondriac region. She subcutaneous crepitations side neck chest. Blood results showed white cell count 15.5×109/L, C reactive protein 13.7 mg/L, amylase 55 IU/L, alanine...
The effect of Adrenaline 0.5 per cent and Guanethidine 2.5 alone in combination reducing intraocular pressure rabbits has been studied. Six were used the efficiencies 5 different dosage protocols was estimated both as intensity duration activity. alone; together; followed 30 min by ?Guanethidine; Adrenaline. single formulation containing drugs appeared to be at least efficient others. Eye drops 1 having sufficient stability for normal use have therefore formulated.
A man in his 20s with a background of relapsing–remitting multiple sclerosis developed spinal cryptococcosis and choroiditis after 8 years therapy the oral immunomodulator fingolimod. The osseous was diagnosed vertebral biopsy, radiological changes C5 vertebra were incidentally identified during routine biannual neuroimaging. He subsequently admitted for intravenous antifungal therapy. During admission, patient reported bilateral floaters found to have choroidal lesions suggestive partially...
<title>Abstract</title> Dominant optic atrophy (DOA) is the most common inherited neuropathy, characterised by selective loss of retinal ganglion cells (RGCs). Over 60% DOA cases are caused pathogenic variants in <italic>OPA1</italic> gene, which encodes a dynamin-related GTPase protein. OPA1 plays key role maintenance mitochondrial network, DNA integrity and bioenergetic function. However, our current understanding how dysfunction contributes to vision patients has been limited access...
A 26-year-old Lithuanian man with type 1 diabetes, diagnosed at aged 14, presented to the emergency department shortness of breath as well left flank pain. The patient was taking a basal-bolus (Actrapid/Lantus) regimen insulin and had no other medical conditions. found be in diabetic ketoacidosis (blood glucose level 21 mmol/L, pH 7.10) chest sepsis based on bilateral consolidation X-ray. admitted high dependency unit treated empirically intravenous flucloxacillin ceftriaxone. Blood cultures...