A5049692462- Corneal Surgery and Treatments
- Corneal surgery and disorders
- Ocular Surface and Contact Lens
- Glaucoma and retinal disorders
- Intraocular Surgery and Lenses
- Ocular Infections and Treatments
- Proteoglycans and glycosaminoglycans research
- Ophthalmology and Visual Impairment Studies
- Antibiotics Pharmacokinetics and Efficacy
- Optical Coherence Tomography Applications
- Drug-Induced Adverse Reactions
- Hemostasis and retained surgical items
- Genomics and Phylogenetic Studies
- Periodontal Regeneration and Treatments
- Connexins and lens biology
- Marine Ecology and Invasive Species
- Vascular Tumors and Angiosarcomas
- Antibiotic Resistance in Bacteria
- Ocular Diseases and Behçet’s Syndrome
- Bacterial biofilms and quorum sensing
- Surgical Simulation and Training
- CNS Lymphoma Diagnosis and Treatment
- Head and Neck Surgical Oncology
- Vascular Anomalies and Treatments
- Ocular Oncology and Treatments
University Hospitals of Derby and Burton NHS Foundation Trust
2023-2025
University of Derby
2025
University of Nottingham
2011-2023
Moorfields Eye Hospital
2022
Moorfields Eye Hospital NHS Foundation Trust
2022
University College London
2022
Queen's Medical Centre
2011-2018
Nottingham University Hospitals NHS Trust
2012-2017
Christie's
2015
The cornea is the clear window at front of eye and eye9s main refractive medium. Its transparency essential for vision. Corneal neovascularisation a common clinical problem with serious consequences vision; it can compromise corneal plays major role in graft rejection by breaching immune privilege. In this review, we formulate consensus on unmet medical needs management outline framework research that needed to identify suitable agents meet these needs.
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To prospectively study patients presenting with sight-threatening corneal ulcers a view to identify the predisposing factors, causative organisms, clinical signs and treatment outcomes.Prospectively, over 3-year period, all cases serious infective keratitis Queens Medical Hospital in Nottingham, UK, were recruited. Detailed information on aetiology, culture results, & symptoms, given patient's response was collected statistically analysed.One hundred forty-three eyes of 129 enrolled....
To evaluate the efficacy of fine needle diathermy (FND) occlusion corneal vessels in relation to defined clinical indications.A retrospective, consecutive case series including all patients treated by FND for between 2004 and 2012. Indications were lipid keratopathy, preparation keratoplasty reduce risk rejection treatment recalcitrant graft associated with stromal vessels. Our outcome measures reduced vascularisation, reduction amount deposition, episodes.FND effectively deposition 14 out...
The trabecular meshwork (TM) located at the angle of anterior chamber eye contributes to aqueous drainage. A novel layer in posterior part human cornea has recently been reported (the pre-Descemet's (Dua's (PDL)). We examined peripheral this relation origin TM.The PDL and TM 19 donor eyes one exenterated sample were studied. Samples by light electron microscopy (EM) for tissue architecture immunohistology four matricellular proteins, five collagen types CD34.EM revealed that beams emerged...
To examine the movement of air injected in cornea simulated deep anterior lamellar keratoplasty (DALK), from needle tip to formation different types big bubbles (BB) and ascertain how travels through stroma pre-Descemet's layer [Dua's (PDL)] create a type-1 (air between PDL stroma) type-2BB Descemet's membrane).Air was 57 sclerocorneal discs passage recorded. Leaking points sites commencement were examined by scanning electron microscopy. Stromal distribution pockets studied light Uninjected...
<h3>Aim</h3> To describe in vivo confocal microscopy (IVCM) features of the limbus normal eyes as related to palisades Vogt9s. <h3>Methods</h3> 46 29 consecutive volunteers were recruited this observational study. A detailed examination by IVCM was performed addition a routine slit-lamp biomicroscopy. Size and density corneal limbal epithelial cells measured statistically analysed using SPSS version 8.0 software. <h3>Results</h3> Anatomical morphological noted between cells. differences...
Differentiating type 1 from 2 big bubbles in deep anterior lamellar keratoplasty Harminder S Dua,1 Tarek Katamish,2 Dalia G Said,1 Lana A Faraj1 1Section of Academic Ophthalmology, Division Clinical Neuroscience, University Nottingham, UK; 2Department Cairo University, Cairo, EgyptWe read with interest the paper by Anwar et al.1 The authors have described a technique to bare Descemet’s membrane (DM) multiple dissection deep corneal stroma when stromal injection air fails achieve...
To determine the refractive outcomes of wavefront-optimized laser in situ keratomileusis (LASIK) treatments, particular to measure corneal densitometry after LASIK using function Pentacam Scheimpflug system.Division Ophthalmology and Visual Sciences, University Nottingham, United Kingdom.Cohort study.Changes postoperative visual acuity, refraction, contrast sensitivity were evaluated treatment. Corneal was with system before LASIK.One year postoperatively, uncorrected distance acuity 6/6 or...
Use of topical glaucoma medications has been reported to cause ocular surface (OS) discomfort and inflammation. This study explores the profile inflammatory cytokines OS symptoms induced in response preserved non-preserved drops.Prospective, randomized evaluation on 36 treatment-naïve patients over 24 months three differently drop preparations: Preservative-free (PF), polyquad (PQ) benzalkonium chloride (BAK). Study participants were evaluated at baseline then 1, 3, 6, 12 while medication....
To clinically characterise corneal neovascularisation (CVas) with a view to elaborate clinical presentations and standardise descriptors for evaluation research.Corneas of 165 patients CVas due variety pathologies were observed the slit lamp biomicroscope photography at different time points over course their disease. Parameters assessed included location, depth, length, branching pattern, colour, lipid leakage, nature blood flow presence haemorrhage. A grading was applied.CVas can arise...
In big bubble (BB), deep anterior lamellar keratoplasty intracorneal injection of air separates Descemet's membrane (DM) and the pre-Descemet's layer (Dua's [DL]) to create a type 1 BB. We tested hypothesis that after excision or ablation DL will fail produce BB.Nine human sclero-corneal discs were used. Three served as controls. three, BB was created, wall excised more injected in an attempt another three samples, DM removed 22μ posterior cornea ablated by phototherapeutic keratectomy...
Lamellar keratoplasty is the preferred option for several indications of corneal transplantation. Deep anterior lamellar (DALK) by "big bubble" (BB) technique revealed clinical clues suggesting existence a defined layer in deep stroma. Simulation DALK donor eyes different types BB and presence compact, tough stromal that impervious to air has paucity keratocytes. Several histological features have been elucidated. The was termed pre-Descemet's (Dua's layer, DL). DL led three innovations...
Abstract The recent discovery and characterization of pre-Descemet’s layer (PDL; also termed the Dua’s or Dua-Fine layer) has advanced understanding various posterior corneal pathologies surgeries in human. This study aimed to characterize ultrastructure stroma interfacial zone Descemet’s membrane (DM) canine eyes. Eighteen corneo-scleral discs were included. Intrastromal air injection resulted formation type 1 big bubble (BB) 73% (n = 11/15) corneas, with a mean diameter 11.0 ± 1.3 mm. No 2...
To establish the level of confidence amongst UK ophthalmology specialist registrars (residents) in managing posterior capsule rupture (PCR) during cataract surgery.An online nine-item questionnaire was distributed to all registrars, recruited nationwide via regional representatives. Data collected included stage training, number completed operations, cumulative PCR rate, PCRs independently managed, understanding vitrectomy settings and fluidic parameters access simulation. Respondents...