A5051052007- Cardiac electrophysiology and arrhythmias
- Glaucoma and retinal disorders
- Intraocular Surgery and Lenses
- Cardiovascular Conditions and Treatments
- Cardiovascular Function and Risk Factors
- Retinal Diseases and Treatments
- Retinal and Macular Surgery
- Ion channel regulation and function
- Retinal and Optic Conditions
- ECG Monitoring and Analysis
- Non-Invasive Vital Sign Monitoring
- Olfactory and Sensory Function Studies
- Glycosylation and Glycoproteins Research
- Pesticide Residue Analysis and Safety
- Ubiquitin and proteasome pathways
- Retinal Imaging and Analysis
- Retinal Development and Disorders
- Corneal surgery and disorders
- Proteoglycans and glycosaminoglycans research
- Cardiac Arrest and Resuscitation
- Electrochemical Analysis and Applications
- Child Abuse and Trauma
- Animal testing and alternatives
- Electromagnetic Fields and Biological Effects
- Surgical Simulation and Training
Data Sciences International (United States)
2014-2024
Little Rock Family Practice Clinic
2021-2024
Counselling Centre for Children, Adolescents and Parents
2024
University of British Columbia
2024
John Radcliffe Hospital
2018-2022
University of Oxford
2003-2020
Royal Berkshire NHS Foundation Trust
2018
Royal Berkshire Hospital
2018
Oxford University Hospitals NHS Trust
2013
The University of Texas Southwestern Medical Center
2010-2013
Drug-induced effects on the cardiovascular system remain a major cause of drug attrition. While hemodynamic (blood pressure (BP) and heart rate (HR)) electrophysiological methods have been used in testing safety for years, animal models assessing myocardial contractility are less frequently their translation to humans has not established. The goal these studies was determine whether assessment hemodynamics, when measured across different laboratories using same protocol, could consistently...
Outcomes after ileal pouch anal anastomosis (IPAA) are not well established in patients with primary sclerosing cholangitis (PSC). We conducted a comprehensive outcomes assessment these patients. A retrospective case note review of complications all PSC-IPAA (n = 21) and matched ulcerative colitis IPAA (UC-IPAA; n 79) surgery Oxford (1983–2012) was conducted, functional (Öresland score) were evaluated (2012). Quality life [Cleveland Global Life Questionnaire, Short Form-36 (SF-36)], sexual...
1. The mucopolysaccharide from the glands of Lorenzini Squalus acanthias has been isolated and purified. 2. material is a sulphated polysaccharide containing glucosamine, galactosamine, galactose traces an uronic acid. 3. This vertebrate unusual in appearing to have both amino sugars present molecule. are N-acetylated. 4. molecule one group related mucopolysaccharides which vary composition with animal species. generic name ;lorenzan sulphates' suggested describe these substances.
With the declaration of coronavirus 2019 (COVID-19) as a pandemic, intensive care units across globe began to prepare for large numbers patients. For many years, UK Intensive Care Units (ICUs) have been at high capacity, while facing staffing shortages. In order predicted increased work caring with COVID-19, staff were redeployed from other clinical areas help. Many these had no previous ICU experience. this article, we share our experiences redeploying medical an extensive range...
The importance of drug-induced effects on the inotropic state heart is well known. Unlike hemodynamic and cardiac electrophysiological methods, which have been routinely used in drug safety testing for years, non-clinical assessment myocardial contractility less frequently with no established translation to humans. goal these studies was determine whether alternate measures inotropy could detect changes contractile using drugs known clinically relevant positive negative contractility. This...
This article examines the ways in which changes treatment environment and measurement perspectives can affect evaluation of cost-effectiveness new medications. In three studies we reexamined data from a clinical trial haloperidol clozapine conducted 1993 to 1996. The results are as follows:
1. The cytosolic aspartate aminotransferase was purified from human liver. 2. isoenzyme contains four cysteine residues, only one of which reacts with 5,5′-dithiobis-(2-nitrobenzoic acid) in the absence denaturing agents. 3. amino acid sequence is reported, as determined peptides produced by digestion trypsin and CNBr, sub-digestion some these Staphylococcus aureus V8 proteinase. 4. shares 48% identity mitochondrial form heart. 5. Comparisons sequences all known mammalian aminotransferases...
ABSTRACT Comb growth was induced in White Leghorn capons by daily treatment with testosterone propionate for 15 days. The hormone then discontinued and the regression of romb course following 24-days period studied respect to content hyaluronic acid, water various protein fractions. size measurements histological studies showed that comb is accompanied reduction finally disappearance so-called mucoid layer, which gives positive histochemical tests presence acidic glycosaminoglycans. Chemical...
Safety studies generate a significant volume of waveform and calculated data. The verification data the process searching through these for patterns interest (including arrhythmias) is time intensive. Data Insights™ has been developed Ponemah™ software platform to provide efficient search capabilities.Searches may be constructed using pattern matching available in Ponemah. Searches are composed one or more clauses that combined Boolean operators (AND, OR). Each clause expression inputs...
Introduction: To determine which patients with visual snow (VS) and VS syndrome (VSS) require standard ophthalmologic testing including automated field further such as macular spectral domain optical coherence tomography (SD-OCT), electrophysiology, neuroimaging. Materials Methods: We retrospectively reviewed 52 consecutive at three institutions VSS the University of Alabama, Callahan Eye Hospital, Missouri-Kansas City School Medicine, Little Rock Clinic from years 2015 to 2021. collected...
To establish the level of confidence amongst UK ophthalmology specialist registrars (residents) in managing posterior capsule rupture (PCR) during cataract surgery.An online nine-item questionnaire was distributed to all registrars, recruited nationwide via regional representatives. Data collected included stage training, number completed operations, cumulative PCR rate, PCRs independently managed, understanding vitrectomy settings and fluidic parameters access simulation. Respondents...
QT has a long history of heart rate (HR) correction but limited investigations have been undertaken to assess the impact cardiovascular parameters on left ventricular (LV) contractility in drug safety testing. Cardiac is affected by preload (Cyon-Frank-Starling law), afterload (Anrep effect) and HR (Bowditch effect). We evaluated multi-parameter methods help with dP/dtmax interpretation.Modeling was using data from dogs single or double 4×4 Latin square studies. Correction models (16 fitting...
A case series was used to evaluate the efficacy of half-fluence photodynamic therapy (PDT) for chronic central serous chorioretinopathy (CSCR). Patients were treated with standard-dose verteporfin and PDT. Totally 13 eyes from 11 patients included. The mean patient age 52.0y. There a reduction in retinal thickness 107.0 microns. 7/13 (53.8%) achieved resolution subretinal fluid (SRF) on optical coherence tomography (OCT) scan after 1 treatment Four had further PDT; these eye SRF. Seven an...
Euthanasia is a necessary component in research and must be conducted humanely. Currently, regulated CO 2 exposure conscious rats acceptable, but data are divided on whether alone more distressing than anesthesia prior to . To evaluate distress rats, we compared physiologic responses euthanasia with without isoflurane preanesthesia. Male Sprague–Dawley were implanted telemetry devices measure mean arterial pressure (MAP), heart rate (HR), blood glucose. Animals recovered for wk then exposed...
The potential for unintended drug induced changes in cardiac contractility is a major concern medicines development. Whilst direct left ventricular pressure (LVP) measurement the gold standard measuring vivo, it resource intensive and poses welfare burden on research animals. In contrast, arterial blood (BP) has fewer challenges. Symmetric Projection Attractor Reconstruction (SPAR) signal processing technique which transforms physiological time-series signals into corresponding visual image...
Exposure to radiofrequency radiation (RFR) may produce thermal responses. Extracellular amino acid concentrations in the hypothalamus (Hyp) and caudate nucleus (CN) were measured by using vivo microdialysis before during exposure RFR. Under urethane anesthetic, each rat was implanted stereotaxically with a nonmetallic probe temperature guides then placed chamber. The laid on its right side head neck directly under wave guide. Temperature probes left brain, face (subcutaneously), tympanum,...
Objectives This study aimed to explore how the unprecedented stressors associated with COVID-19 pandemic may have contributed heightened levels of depression and anxiety among pregnant Indigenous persons, identify protective individual-level factors. Design The current used a mixed-methods design including standardised questionnaires open-ended response questions. Using hierarchical regression models, we examined extent which COVID-19-related factors service disruption (ie, changes prenatal...