A5064745136- Multiple Sclerosis Research Studies
- Peripheral Neuropathies and Disorders
- Autoimmune Neurological Disorders and Treatments
- Neurogenesis and neuroplasticity mechanisms
- Hereditary Neurological Disorders
- Systemic Lupus Erythematosus Research
- Long-Term Effects of COVID-19
- Retinal and Optic Conditions
- Congenital heart defects research
- Viral Infections and Immunology Research
- Cerebral Venous Sinus Thrombosis
- Reproductive Biology and Fertility
- Genetics and Neurodevelopmental Disorders
- RNA regulation and disease
- Childhood Cancer Survivors' Quality of Life
- Adolescent and Pediatric Healthcare
- Complement system in diseases
- Autoimmune and Inflammatory Disorders Research
- Polyomavirus and related diseases
- Systemic Sclerosis and Related Diseases
- RNA modifications and cancer
- Blood disorders and treatments
- Adenosine and Purinergic Signaling
- Sleep and related disorders
- Virology and Viral Diseases
Klinikum Stuttgart
2019-2025
Olgahospital
2018-2025
Max Delbrück Center
2024
Charité - Universitätsmedizin Berlin
2024
Witten/Herdecke University
2024
SMART Reading
2024
Euroimmun Medizinische Labordiagnostika (Germany)
2021
Innsbruck Medical University
2019-2020
Amsterdam UMC Location Vrije Universiteit Amsterdam
2016
University Hospital and Clinics
2016
<h3>Objective</h3> To describe the presentations, radiologic features, and outcomes of children with autoimmune encephalitis associated myelin oligodendrocyte glycoprotein antibodies (MOG abs). <h3>Methods</h3> Identification fulfilling diagnostic criteria for possible (AE) testing positive serum MOG abs. Chart review comprehensive analysis abs using live cell assays rat brain immunohistochemistry. <h3>Results</h3> Ten (4 girls, 6 boys) AE were identified. The median age at onset was 8.0...
Myelin oligodendrocyte glycoprotein (MOG)-antibody (Ab)-associated diseases (MOGADs) account for a substantial proportion of pediatric and adult patients who present with acquired demyelinating disorders. Its pathogenesis optimal therapy are incompletely understood. We profiled systemic complement activation in MOGAD compared relapse-onset multiple sclerosis, neuromyelitis optica spectrum disorder, control healthy donors. Proteins indicative classical alternative were substantially increased...
Objective: To assess the diagnostic and prognostic potential of serum neurofilament light chain (sNfL) in children with first acquired demyelinating syndrome (ADS). Methods: We selected 129 ADS including 19 myelin oligodendrocyte glycoprotein (MOG)-antibody associated disease (MOGAD), 36 MOG/AQP4-seronegative ADS, 74 multiple sclerosis (MS) from BIOMARKER study cohort. All had a complete set clinical, radiological, laboratory data for NfL measurement using highly sensitive digital ELISA...
Myelin oligodendrocyte glycoprotein (MOG)-antibody (Ab)-associated disease (MOGAD) is an inflammatory demyelinating of the CNS. Although MOG encephalitogenic in different mammalian species, mechanisms by which human MOG-specific Abs contribute to MOGAD are poorly understood. Here, we use a systems-level approach combined with high-dimensional characterization Ab-associated immune features deeply profile humoral responses 123 patients MOGAD. We show that age major determinant for...
<h3>Objective</h3> To analyze serum immunoglobulin G (IgG) antibodies to major isoforms of myelin oligodendrocyte glycoprotein (MOG-alpha 1-3 and beta 1-3) in patients with inflammatory demyelinating diseases. <h3>Methods</h3> Retrospective case-control study using 378 samples from multiple sclerosis (MS), non-MS disease, healthy controls MOG alpha-1-IgG positive (n = 202) or negative serostatus 176). Samples were analyzed for their reactivity human, mouse, rat without mutations the...
Autoantibody-associated demyelinating diseases of the central nervous system such as myelin oligodendrocyte glycoprotein-antibody associated disease (MOGAD) and aquaporin 4-antibody positive neuromyelitis optica spectrum disorders (AQP4+ NMOSD) are rare but can cause severe disability. In both diseases, neuroinflammation is accompanied by blood cerebrospinal fluid cytokine chemokine signatures, which were shown to be distinct from those observed in patients with multiple sclerosis (MS). this...
Current practices in counselling of female cancer patients with respect to fertility issues need considerable improvement, particularly given the general underuse preservation options and negative impact that infertility can have on quality life. We investigated relationship between physicians' physician-related factors frequency physicians discussing referring a reproductive specialist. invited 1,832 Netherlands who had treated at least five reproductive-age within past year complete...
Abstract Background Optic neuritis (ON) is the most prevalent manifestation of pediatric multiple sclerosis (MS ped ) and myelin-oligodendrocyte glycoprotein antibody-associated disease (MOGAD in children > 6 years. In this study, we investigated retinal atrophy patterns diagnostic accuracy optical coherence tomography (OCT) differentiating between both diseases after first ON episode. Methods Patients were retrospectively identified eight tertial referral centers. OCT, VEP...
Background: Neuromyelitis optica spectrum disorders (NMOSD) are severe inflammatory demyelinating of the central nervous system mainly characterized by recurrent episodes uni- or bilateral optic neuritis (ON), transverse myelitis (TM) and brainstem syndromes (BS). The majority adult patients has serum antibodies directed against water channel protein aquaporin 4 (AQP4-abs). In pediatric patients, AQP4-abs less, while myelin oligodendrocyte glycoprotein (MOG-abs) more frequently detectable...
Abstract Recent reports indicated that myelin oligodendrocyte glycoprotein antibody-associated disease might be a rare complication after severe acute respiratory syndrome coronavirus 2 infection or vaccination. It is unclear whether this an unspecific sequel of vaccination caused by possible immunological cross-reactivity proteins and glycoprotein. The aim study was therefore to elucidate there between spike nucleocapsid explore the relation antibody responses against other coronaviruses....
Patients with myelin oligodendrocyte glycoprotein antibody-associated disorders (MOGAD) clinically present e.g. acute disseminated encephalomyelitis (ADEM), optic neuritis (ON), transverse myelitis (TM) or aquaporin-4-IgG (AQP4-IgG) negative neuromyelitis optica spectrum (NMOSD)-like phenotypes. We aimed to analyze and compare blood parameters in children MOGAD, AQP4-IgG-positive NMOSD (hence NMOSD), multiple sclerosis (MS) healthy controls (HC).
Acute cerebellitis (AC) in children and adolescents is an inflammatory disease of the cerebellum due to viral or bacterial infections but also autoimmune-mediated processes.